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Go with the flow: signaling from the ventricle directs neuroblast migration

Neurons born in the adult subventricular zone migrate a long way to their destination. A new study suggests that signals from the corticospinal fluid, in particular the chemorepellent Slit2, guide adult neuroblast migration.

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Figure 1: Sagittal sections of the adult rodent telencephalon.

Ann Thomson

References

  1. Alvarez-Buylla, A., Garcia-Verdugo, J.M. & Tramontin, A.D. Nat. Rev. Neurosci. 2, 287–293 (2001).

    Article  CAS  Google Scholar 

  2. Götz, M. & Huttner, W.B. Nat. Rev. Mol. Cell Biol. 6, 777–788 (2005).

    Article  Google Scholar 

  3. Sawamoto, K. et al. Science 311, 629–632 (2006).

    Article  CAS  Google Scholar 

  4. Ibanez-Tallon, I. et al. Hum. Mol. Genet. 13, 2133–2141 (2004).

    Article  CAS  Google Scholar 

  5. Banizs, B. et al. Development 132, 5329–5339 (2005).

    Article  CAS  Google Scholar 

  6. Davson, H. & Segal, M.B. Physiology of the CSF and Blood-Brain Barriers (CRC Press, Boca Raton, Florida, 1996).

    Google Scholar 

  7. Hu, H. Neuron 23, 703–711 (1999).

    Article  CAS  Google Scholar 

  8. Nguyen-Ba-Charvet, K.T. et al. J. Neurosci. 24, 1497–1506 (2004).

    Article  CAS  Google Scholar 

  9. Tanaka, Y., Okada, Y. & Hirokawa, N. Nature 435, 172–177 (2005).

    Article  CAS  Google Scholar 

  10. Murcia, N.S. et al. Development 127, 2347–2355 (2000).

    CAS  PubMed  Google Scholar 

  11. Ibanez-Tallon, I., Heintz, N. & Omran, H. Hum. Mol. Genet. 12, R27–R35 (2003).

    Article  CAS  Google Scholar 

  12. Davenport, J.R. & Yoder, B.K. Am. J. Physiol. Renal Physiol. 289, F1159–1169 (2005).

    Article  CAS  Google Scholar 

  13. Corbit, K.C. et al. Nature 437, 1018–1021 (2005).

    Article  CAS  Google Scholar 

  14. Marzesco, A.M. et al. J. Cell Sci. 118, 2849–2858 (2005).

    Article  CAS  Google Scholar 

  15. Nauli, S.M. et al. Nat. Genet. 33, 129–137 (2003).

    Article  CAS  Google Scholar 

Download references

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Götz, M., Stricker, S. Go with the flow: signaling from the ventricle directs neuroblast migration. Nat Neurosci 9, 470–472 (2006). https://doi.org/10.1038/nn0406-470

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