Volume 3 Issue 1, January 2000

Volume 3 Issue 1

Rosenthal and colleagues report that a constitutively active form of Smoothened (green) mimics concentration-dependent actions of Sonic Hedgehog in the developing neural tube, including activation of ventral markers (such as Nkx2.2, red), suppression of dorsal markers and induction of multiple classes of ventral and ventrolateral neurons. These patterning activities are cell autonomous, occurring only in cells that express Smoothened. See page 41.

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