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A study reports for the first time on the importance of post-translational modification by neddylation in postnatal brain development. In particular, it is critical to synapse maturation and stability, and thus to cognition.
Harris and Shepherd review our knowledge of input and output patterns for different classes of cortical cells. They propose that cortex, like other parts of the body, has a serially homologous organization, featuring area- and species-specific variations on a basic theme, that allows different types of function to emerge.