Articles

  • Article |

    When co-cultured with activated microglia, iPSC-derived interneurons from individuals with schizophrenia and from healthy controls show defects in metabolic pathways, but only the interneurons from individuals with schizophrenia showed prolonged metabolic deficits.

    • Gun-Hoo Park
    • , Haneul Noh
    • , Zhicheng Shao
    • , Peiyan Ni
    • , Yiren Qin
    • , Dongxin Liu
    • , Cameron P. Beaudreault
    • , Joy S. Park
    • , Chiderah P. Abani
    • , James M. Park
    • , Derek T. Le
    • , Sasha Z. Gonzalez
    • , Youxin Guan
    • , Bruce M. Cohen
    • , Donna L. McPhie
    • , Joseph T. Coyle
    • , Thomas A. Lanz
    • , Hualin S. Xi
    • , Changhong Yin
    • , Weihua Huang
    • , Hae-Young Kim
    •  & Sangmi Chung
  • Article |

    Peripheral macrophages located along motor axons react differently to neurodegeneration compared to CNS microglia in ALS mice. Modifying peripheral macrophages suppresses proinflammatory microglial responses, shifting them toward neuronal support.

    • Aude Chiot
    • , Sakina Zaïdi
    • , Charlène Iltis
    • , Matthieu Ribon
    • , Félix Berriat
    • , Lorenzo Schiaffino
    • , Ariane Jolly
    • , Pierre de la Grange
    • , Michel Mallat
    • , Delphine Bohl
    • , Stéphanie Millecamps
    • , Danielle Seilhean
    • , Christian S. Lobsiger
    •  & Séverine Boillée
  • Article |

    Donegan et al. show that hippocampal CA2 neurons contribute to social memory by encoding social novelty. Abnormal CA2 coding and social memory in a mouse model of the 22q11.2 microdeletion are rescued by blocking elevated CA2 TREK-1 K+ current.

    • Macayla L. Donegan
    • , Fabio Stefanini
    • , Torcato Meira
    • , Joshua A. Gordon
    • , Stefano Fusi
    •  & Steven A. Siegelbaum
  • Article |

    Kohro et al. identify a population of astrocytes located in the superficial dorsal horn of adult spinal cord (genetically defined by Hes5) that acts as a gate for locus coeruleus descending noradrenergic control of mechanosensory hypersensitivity.

    • Yuta Kohro
    • , Tsuyoshi Matsuda
    • , Kohei Yoshihara
    • , Keita Kohno
    • , Keisuke Koga
    • , Ryuichi Katsuragi
    • , Takaaki Oka
    • , Ryoichi Tashima
    • , Sho Muneta
    • , Takuya Yamane
    • , Shota Okada
    • , Kazuya Momokino
    • , Aogu Furusho
    • , Kenji Hamase
    • , Takumi Oti
    • , Hirotaka Sakamoto
    • , Kenichiro Hayashida
    • , Ryosuke Kobayashi
    • , Takuro Horii
    • , Izuho Hatada
    • , Hidetoshi Tozaki-Saitoh
    • , Katsuhiko Mikoshiba
    • , Verdon Taylor
    • , Kazuhide Inoue
    •  & Makoto Tsuda
  • Article |

    This study demonstrates that basal ganglia functional topography is maintained across and downstream of its output nuclei, and in closed loops. Focal stimulation of distinct striatal subregions induces distinct action, supporting a model of parallel behavioral control.

    • Jaeeon Lee
    • , Wengang Wang
    •  & Bernardo L. Sabatini
  • Article |

    Kusick et al. capture snapshots of synaptic vesicle docking and fusion using a new time-resolved electron microscopy technique. They find that vesicles are replaced milliseconds after they fuse, which may contribute to short-term synaptic plasticity.

    • Grant F. Kusick
    • , Morven Chin
    • , Sumana Raychaudhuri
    • , Kristina Lippmann
    • , Kadidia P. Adula
    • , Edward J. Hujber
    • , Thien Vu
    • , M. Wayne Davis
    • , Erik M. Jorgensen
    •  & Shigeki Watanabe
  • Article |

    Yamamuro et al. show that juvenile social isolation disrupts prefrontal neurons projecting to the paraventricular thalamus and associated prefrontal somatostatin interneurons, and thereby impairs sociability in adulthood.

    • Kazuhiko Yamamuro
    • , Lucy K. Bicks
    • , Michael B. Leventhal
    • , Daisuke Kato
    • , Susanna Im
    • , Meghan E. Flanigan
    • , Yury Garkun
    • , Kevin J. Norman
    • , Keaven Caro
    • , Masato Sadahiro
    • , Klas Kullander
    • , Schahram Akbarian
    • , Scott J. Russo
    •  & Hirofumi Morishita
  • Article |

    Babetto et al. demonstrate an axonal injury-induced glycolytic surge in Schwann cells that supplies perturbed axons with glycolytic energy substrates. Disruption of this metabolic coupling of axons and glial cells promotes axonal degeneration.

    • Elisabetta Babetto
    • , Keit Men Wong
    •  & Bogdan Beirowski
  • Article |

    Parkinson’s disease brain neurons exhibit a widespread epigenetic dysregulation of enhancers that is linked to an upregulation of TET2. Inactivation of TET2 protects against nigral dopaminergic neuronal loss and neuroinflammation.

    • Lee L. Marshall
    • , Bryan A. Killinger
    • , Elizabeth Ensink
    • , Peipei Li
    • , Katie X. Li
    • , Wei Cui
    • , Noah Lubben
    • , Matthew Weiland
    • , Xinhe Wang
    • , Juozas Gordevicius
    • , Gerhard A. Coetzee
    • , Jiyan Ma
    • , Stefan Jovinge
    •  & Viviane Labrie
  • Article |

    The nervous system is hypothesized to calculate reward prediction errors to estimate reward availability in the environment. The authors quantify a robust prediction error signal in the ventral pallidum derived from recently received rewarding outcomes.

    • David J. Ottenheimer
    • , Bilal A. Bari
    • , Elissa Sutlief
    • , Kurt M. Fraser
    • , Tabitha H. Kim
    • , Jocelyn M. Richard
    • , Jeremiah Y. Cohen
    •  & Patricia H. Janak
  • Article |

    Park et al. demonstrate in tauopathy models that tau disrupts the interaction between neuronal nitric oxide synthase and PSD95, uncoupling glutamatergic synaptic activity from nitric oxide production and dampening the hemodynamic response to activation.

    • Laibaik Park
    • , Karin Hochrainer
    • , Yorito Hattori
    • , Sung Ji Ahn
    • , Antoine Anfray
    • , Gang Wang
    • , Ken Uekawa
    • , James Seo
    • , Victoria Palfini
    • , Ismary Blanco
    • , Diana Acosta
    • , David Eliezer
    • , Ping Zhou
    • , Josef Anrather
    •  & Costantino Iadecola
  • Article |

    The authors showed that the ‘moment of perception’ is causally related to dendritic activity in subcortically projecting layer 5 pyramidal neurons that project to the higher-order thalamus, superior colliculus and striatum.

    • Naoya Takahashi
    • , Christian Ebner
    • , Johanna Sigl-Glöckner
    • , Sara Moberg
    • , Svenja Nierwetberg
    •  & Matthew E. Larkum
  • Article |

    Mazzone and Liang-Guallpa et al. demonstrate that consuming high-fat foods rapidly and durably tunes parallel brain circuits to drive intake of a high-fat diet while devaluing a nutritionally balanced, standard diet even under states of intense hunger.

    • Christopher M. Mazzone
    • , Jing Liang-Guallpa
    • , Chia Li
    • , Nora S. Wolcott
    • , Montana H. Boone
    • , Morgan Southern
    • , Nicholas P. Kobzar
    • , Isabel de Araujo Salgado
    • , Deepa M. Reddy
    • , Fangmiao Sun
    • , Yajun Zhang
    • , Yulong Li
    • , Guohong Cui
    •  & Michael J. Krashes
  • Article |

    Charlet, Grinevich et al. show that social touch between female rats activates parvocellular oxytocin neurons; these neurons control social behavior by coordinating the responses of the much larger population of magnocellular oxytocin neurons.

    • Yan Tang
    • , Diego Benusiglio
    • , Arthur Lefevre
    • , Louis Hilfiger
    • , Ferdinand Althammer
    • , Anna Bludau
    • , Daisuke Hagiwara
    • , Angel Baudon
    • , Pascal Darbon
    • , Jonas Schimmer
    • , Matthew K. Kirchner
    • , Ranjan K. Roy
    • , Shiyi Wang
    • , Marina Eliava
    • , Shlomo Wagner
    • , Martina Oberhuber
    • , Karl K. Conzelmann
    • , Martin Schwarz
    • , Javier E. Stern
    • , Gareth Leng
    • , Inga D. Neumann
    • , Alexandre Charlet
    •  & Valery Grinevich
  • Article |

    Yamaguchi et al. identify a little-known amygdalar region, the posterior amygdala, as a key node in male mouse social behaviors. Two largely non-overlapping subpopulations in the posterior amygdala form parallel projections to distinct hypothalamic regions to regulate mating and fighting.

    • Takashi Yamaguchi
    • , Dongyu Wei
    • , Soomin C. Song
    • , Byungkook Lim
    • , Nicolas X. Tritsch
    •  & Dayu Lin
  • Article |

    Tamaki et al. measured MRS changes in sleeping humans trained on a visual task. During NREM sleep, learning gains were associated with enhanced visual cortical plasticity that was also seen independent of learning. REM sleep stabilized plasticity only after pre-sleep learning.

    • Masako Tamaki
    • , Zhiyan Wang
    • , Tyler Barnes-Diana
    • , DeeAnn Guo
    • , Aaron V. Berard
    • , Edward Walsh
    • , Takeo Watanabe
    •  & Yuka Sasaki
  • Article |

    Giovannoni et al. report that the aryl hydrocarbon receptor (AHR) is a novel host factor exploited by Zika virus and dengue virus to evade the immune response. AHR is a candidate target for the treatment of Zika virus congenital syndrome and dengue fever.

    • Federico Giovannoni
    • , Irene Bosch
    • , Carolina Manganeli Polonio
    • , María F. Torti
    • , Michael A. Wheeler
    • , Zhaorong Li
    • , Leonardo Romorini
    • , María S. Rodriguez Varela
    • , Veit Rothhammer
    • , Andreia Barroso
    • , Emily C. Tjon
    • , Liliana M. Sanmarco
    • , Maisa C. Takenaka
    • , Seyed Mohamad Sadegh Modaresi
    • , Cristina Gutiérrez-Vázquez
    • , Nágela Ghabdan Zanluqui
    • , Nilton Barreto dos Santos
    • , Carolina Demarchi Munhoz
    • , Zhongyan Wang
    • , Elsa B. Damonte
    • , David Sherr
    • , Lee Gehrke
    • , Jean Pierre Schatzmann Peron
    • , Cybele C. Garcia
    •  & Francisco J. Quintana
  • Article |

    Kelly et al. describe two cerebellum–thalamus–mPFC pathways in mice that regulate social and repetitive behavior. PC activation in Rcrus1 and posterior vermis improved social and reduced repetitive behaviors, respectively, in PC-Tsc1 mutant mice.

    • Elyza Kelly
    • , Fantao Meng
    • , Hirofumi Fujita
    • , Felipe Morgado
    • , Yasaman Kazemi
    • , Laura C. Rice
    • , Chongyu Ren
    • , Christine Ochoa Escamilla
    • , Jennifer M. Gibson
    • , Sanaz Sajadi
    • , Robert J. Pendry
    • , Tommy Tan
    • , Jacob Ellegood
    • , M. Albert Basson
    • , Randy D. Blakely
    • , Scott V. Dindot
    • , Christelle Golzio
    • , Maureen K. Hahn
    • , Nicholas Katsanis
    • , Diane M. Robins
    • , Jill L. Silverman
    • , Karun K. Singh
    • , Rachel Wevrick
    • , Margot J. Taylor
    • , Christopher Hammill
    • , Evdokia Anagnostou
    • , Brad E. Pfeiffer
    • , Catherine J. Stoodley
    • , Jason P. Lerch
    • , Sascha du Lac
    •  & Peter T. Tsai
  • Article |

    Most studies of autism spectrum disorder (ASD) have focused on neuronal mechanisms. Here, the authors describe vascular impairments in a mouse model of 16p11.2 deletion syndrome using physiological and genetic approaches to examine endothelial-dependent phenotypes.

    • Julie Ouellette
    • , Xavier Toussay
    • , Cesar H. Comin
    • , Luciano da F. Costa
    • , Mirabelle Ho
    • , María Lacalle-Aurioles
    • , Moises Freitas-Andrade
    • , Qing Yan Liu
    • , Sonia Leclerc
    • , Youlian Pan
    • , Ziying Liu
    • , Jean-François Thibodeau
    • , Melissa Yin
    • , Micael Carrier
    • , Cameron J. Morse
    • , Peter Van Dyken
    • , Christopher J. Bergin
    • , Sylvain Baillet
    • , Christopher R. Kennedy
    • , Marie-Ève Tremblay
    • , Yannick D. Benoit
    • , William L. Stanford
    • , Dylan Burger
    • , Duncan J. Stewart
    •  & Baptiste Lacoste
  • Article |

    Laszlovszky et al. demonstrate the presence of two types of cholinergic neurons that differ in cellular physiology, coupling with cortical oscillations, synchrony within each group, behavior performance correlates and anatomical distribution.

    • Tamás Laszlovszky
    • , Dániel Schlingloff
    • , Panna Hegedüs
    • , Tamás F. Freund
    • , Attila Gulyás
    • , Adam Kepecs
    •  & Balázs Hangya
  • Article |

    Lovett-Barron et al. register in situ gene expression to cellular-level neural dynamics in behaving zebrafish and find threat-selective populations spanning multiple hypothalamic peptidergic neuron classes, which converge on brainstem defensive action premotor neurons.

    • Matthew Lovett-Barron
    • , Ritchie Chen
    • , Susanna Bradbury
    • , Aaron S. Andalman
    • , Mahendra Wagle
    • , Su Guo
    •  & Karl Deisseroth
  • Article |

    Barbosa, Stein et al. show that rather than operating independently, PFC persistent activity and ‘activity-silent’ mechanisms interact dynamically to produce serial effects in working memory, consistent with attractor models with synaptic plasticity.

    • Joao Barbosa
    • , Heike Stein
    • , Rebecca L. Martinez
    • , Adrià Galan-Gadea
    • , Sihai Li
    • , Josep Dalmau
    • , Kirsten C. S. Adam
    • , Josep Valls-Solé
    • , Christos Constantinidis
    •  & Albert Compte
  • Article |

    Using data from top neuroscience journals, this study finds that women-led work tends to be undercited relative to expectations. This imbalance is driven largely by the citation practices of men and is increasing over time as the field diversifies.

    • Jordan D. Dworkin
    • , Kristin A. Linn
    • , Erin G. Teich
    • , Perry Zurn
    • , Russell T. Shinohara
    •  & Danielle S. Bassett
  • Article |

    Mice with AD-like pathology and memory impairments surprisingly have memory engrams in their hippocampus. However, interference with novelty-like cells prevents proper recall, erroneously letting mice perceive a previously learned context as novel.

    • Stefanie Poll
    • , Manuel Mittag
    • , Fabrizio Musacchio
    • , Lena C. Justus
    • , Eleonora Ambrad Giovannetti
    • , Julia Steffen
    • , Jens Wagner
    • , Lioba Zohren
    • , Susanne Schoch
    • , Boris Schmidt
    • , Walker S. Jackson
    • , Dan Ehninger
    •  & Martin Fuhrmann
  • Article |

    Andreone, Przybyla et al. used induced pluripotent stem cell-derived human microglia to show that TREM2-dependent phagocytosis and lipid metabolism require the Alzheimer’s risk factor PLCγ2, which can also mediate TREM2-independent inflammatory signaling via Toll-like receptors.

    • Benjamin J. Andreone
    • , Laralynne Przybyla
    • , Ceyda Llapashtica
    • , Anil Rana
    • , Sonnet S. Davis
    • , Bettina van Lengerich
    • , Karin Lin
    • , Ju Shi
    • , Yuan Mei
    • , Giuseppe Astarita
    • , Gilbert Di Paolo
    • , Thomas Sandmann
    • , Kathryn M. Monroe
    •  & Joseph W. Lewcock
  • Article |

    Wimmer et al. show that successful recall of an extended episode of experience in humans is associated with temporally compressed replay of neural patterns associated with the memory, and that the direction of replay depends on task goals.

    • G. Elliott Wimmer
    • , Yunzhe Liu
    • , Neža Vehar
    • , Timothy E. J. Behrens
    •  & Raymond J. Dolan
  • Article |

    Cellular imaging reveals that visual cue-evoked activity patterns in visual association cortex are reactivated during subsequent quiet waking. Reactivation rates scale with cue salience and predict next-day changes in functional connectivity and behavior.

    • Arthur U. Sugden
    • , Jeffrey D. Zaremba
    • , Lauren A. Sugden
    • , Kelly L. McGuire
    • , Andrew Lutas
    • , Rohan N. Ramesh
    • , Osama Alturkistani
    • , Kristian K. Lensjø
    • , Christian R. Burgess
    •  & Mark L. Andermann
  • Article |

    An et al. discovered a new brain pathway in mice that conveys light signals from the retina to mood-relevant subcortical nuclei under circadian gating and thereby mediates depressive-like behaviors induced by abnormal nighttime light exposure.

    • Kai An
    • , Huan Zhao
    • , Ying Miao
    • , Qi Xu
    • , Yu-Fei Li
    • , Yu-Qian Ma
    • , Yi-Ming Shi
    • , Jia-Wei Shen
    • , Jian-Jun Meng
    • , Yong-Gang Yao
    • , Zhi Zhang
    • , Ju-Tao Chen
    • , Jin Bao
    • , Mei Zhang
    •  & Tian Xue
  • Article |

    A genetic study of problematic alcohol use in 435,563 individuals, including data from the Million Veteran Program, Psychiatric Genomics Consortium and UK Biobank, found many novel risk loci and provided new insights into trait biology.

    • Hang Zhou
    • , Julia M. Sealock
    • , Sandra Sanchez-Roige
    • , Toni-Kim Clarke
    • , Daniel F. Levey
    • , Zhongshan Cheng
    • , Boyang Li
    • , Renato Polimanti
    • , Rachel L. Kember
    • , Rachel Vickers Smith
    • , Johan H. Thygesen
    • , Marsha Y. Morgan
    • , Stephen R. Atkinson
    • , Mark R. Thursz
    • , Mette Nyegaard
    • , Manuel Mattheisen
    • , Anders D. Børglum
    • , Emma C. Johnson
    • , Amy C. Justice
    • , Abraham A. Palmer
    • , Andrew McQuillin
    • , Lea K. Davis
    • , Howard J. Edenberg
    • , Arpana Agrawal
    • , Henry R. Kranzler
    •  & Joel Gelernter
  • Article |

    Assessing residual consciousness in unresponsive patients is a major clinical concern. Gui et al. demonstrate that EEG-based language assessment can objectively characterize states of consciousness and predict outcomes in individual patients.

    • Peng Gui
    • , Yuwei Jiang
    • , Di Zang
    • , Zengxin Qi
    • , Jiaxing Tan
    • , Hiromi Tanigawa
    • , Jian Jiang
    • , Yunqing Wen
    • , Long Xu
    • , Jizong Zhao
    • , Ying Mao
    • , Mu-ming Poo
    • , Nai Ding
    • , Stanislas Dehaene
    • , Xuehai Wu
    •  & Liping Wang
  • Article |

    This study elucidates how long-range chromatin loops are altered during short- and long-term changes in neural activity, and analyzes the interplay between the 3D genome and the linear epigenome during activity-dependent transcriptional responses.

    • Jonathan A. Beagan
    • , Elissa D. Pastuzyn
    • , Lindsey R. Fernandez
    • , Michael H. Guo
    • , Kelly Feng
    • , Katelyn R. Titus
    • , Harshini Chandrashekar
    • , Jason D. Shepherd
    •  & Jennifer E. Phillips-Cremins
  • Article |

    Shen et al. report that prolonged obesity is associated with cerebrovascular dysfunction and Tak1 activation in brainstem microglia. Pharmacological inhibition or genetic depletion of Tak1 restores cerebrovascular function in obese mice.

    • Qing Shen
    • , Zhuo Chen
    • , Faming Zhao
    • , Susu Pan
    • , Tingting Zhang
    • , Xueer Cheng
    • , Lei Zhang
    • , Shanshan Zhang
    • , Junxia Qi
    • , Juxue Li
    • , Dongsheng Cai
    •  & Guo Zhang
  • Article |

    Precisely timed motor learning promotes remyelination in the motor cortex by enhancing oligodendrogenesis and stimulating mature oligodendrocytes to generate new myelin, presenting mature oligodendrocytes as new targets in remyelinating therapies.

    • Clara M. Bacmeister
    • , Helena J. Barr
    • , Crystal R. McClain
    • , Michael A. Thornton
    • , Dailey Nettles
    • , Cristin G. Welle
    •  & Ethan G. Hughes
  • Article |

    Hua and Chen et al. show that general anesthesia activates a distinct population of central amygdala neurons and that these neurons can potently suppress pain responses through their widespread projections to many pain-processing centers in the brain.

    • Thuy Hua
    • , Bin Chen
    • , Dongye Lu
    • , Katsuyasu Sakurai
    • , Shengli Zhao
    • , Bao-Xia Han
    • , Jiwoo Kim
    • , Luping Yin
    • , Yong Chen
    • , Jinghao Lu
    •  & Fan Wang
  • Article |

    Medulloblastomas lacking p53 do not express surface class I major histocompatibility complex (MHC-I) and are resistant to immune rejection. Tumor necrosis factor rescues MHC-I expression and synergizes with immune checkpoint inhibitors to promote rejection.

    • Alexandra Garancher
    • , Hiromichi Suzuki
    • , Svasti Haricharan
    • , Lianne Q. Chau
    • , Meher Beigi Masihi
    • , Jessica M. Rusert
    • , Paula S. Norris
    • , Florent Carrette
    • , Megan M. Romero
    • , Sorana A. Morrissy
    • , Patryk Skowron
    • , Florence M. G. Cavalli
    • , Hamza Farooq
    • , Vijay Ramaswamy
    • , Steven J. M. Jones
    • , Richard A. Moore
    • , Andrew J. Mungall
    • , Yussanne Ma
    • , Nina Thiessen
    • , Yisu Li
    • , Alaide Morcavallo
    • , Lin Qi
    • , Mari Kogiso
    • , Yuchen Du
    • , Patricia Baxter
    • , Jacob J. Henderson
    • , John R. Crawford
    • , Michael L. Levy
    • , James M. Olson
    • , Yoon-Jae Cho
    • , Aniruddha J. Deshpande
    • , Xiao-Nan Li
    • , Louis Chesler
    • , Marco A. Marra
    • , Harald Wajant
    • , Oren J. Becher
    • , Linda M. Bradley
    • , Carl F. Ware
    • , Michael D. Taylor
    •  & Robert J. Wechsler-Reya
  • Article |

    Cregg et al. find that a specific population of brainstem neurons act to control left–right turning of locomotor movements in mammals through distinct axial- and limb-based mechanisms. This turning pathway is the dominant system for natural directional movements.

    • Jared M. Cregg
    • , Roberto Leiras
    • , Alexia Montalant
    • , Paulina Wanken
    • , Ian R. Wickersham
    •  & Ole Kiehn
  • Article |

    The authors establish the claustrum-Cre transgenic mouse line and demonstrate that the claustrum orchestrates cortical slow-wave activity by synchronously driving the inhibitory interneurons in widespread cortical areas.

    • Kimiya Narikiyo
    • , Rumiko Mizuguchi
    • , Ayako Ajima
    • , Momoko Shiozaki
    • , Hiroki Hamanaka
    • , Joshua P. Johansen
    • , Kensaku Mori
    •  & Yoshihiro Yoshihara
  • Article |

    Marshall et al. show that regions of the genome adopt a noncanonical Z-DNA state in the prefrontal cortex in response to fear learning and that binding of Adar1 reduces Z-DNA during extinction learning, which is required for memory flexibility.

    • Paul R. Marshall
    • , Qiongyi Zhao
    • , Xiang Li
    • , Wei Wei
    • , Ambika Periyakaruppiah
    • , Esmi L. Zajaczkowski
    • , Laura J. Leighton
    • , Sachithrani U. Madugalle
    • , Dean Basic
    • , Ziqi Wang
    • , Jiayu Yin
    • , Wei-Siang Liau
    • , Ankita Gupte
    • , Carl R. Walkley
    •  & Timothy W. Bredy