Jennie Vallis

Focus on neuroscience methods

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Open Access options available from January 2021, read more

Latest Research

  • Article |

    When people are isolated, they crave social interactions. Midbrain craving regions were activated by food in hungry people, and by social interactions in people mandated to be isolated.

    • Livia Tomova
    • , Kimberly L. Wang
    • , Todd Thompson
    • , Gillian A. Matthews
    • , Atsushi Takahashi
    • , Kay M. Tye
    •  & Rebecca Saxe
  • Article |

    Pacheco et al. present new methods for the unbiased recording and cataloging of sensory activity throughout the Drosophila brain and across trials and individuals. They find auditory activity is temporally diverse but present in neurons throughout nearly all central brain regions.

    • Diego A. Pacheco
    • , Stephan Y. Thiberge
    • , Eftychios Pnevmatikakis
    •  & Mala Murthy
  • Article |

    Ong et al. analyzed behavior, gaze patterns and neuronal activity of monkeys playing the game ‘chicken’. Monkeys seemed to develop models of the behavior of the partner, and neurons in the mSTS and the ACCg signaled strategic information to guide their decisions.

    • Wei Song Ong
    • , Seth Madlon-Kay
    •  & Michael L. Platt
  • Technical Report |

    A method for parameterizing electrophysiological neural power spectra into periodic and aperiodic components is introduced, addressing limitations of common approaches. The method is validated in simulation and demonstrated on real data applications.

    • Thomas Donoghue
    • , Matar Haller
    • , Erik J. Peterson
    • , Paroma Varma
    • , Priyadarshini Sebastian
    • , Richard Gao
    • , Torben Noto
    • , Antonio H. Lara
    • , Joni D. Wallis
    • , Robert T. Knight
    • , Avgusta Shestyuk
    •  & Bradley Voytek
  • Review Article |

    This Review discusses two high-throughput techniques—massively parallel reporter assays (MPRAs) and CRISPR screens—focusing on their potential to validate non-coding genetic risk variants in human stem cell models of complex brain disorders.

    • Kayla G. Townsley
    • , Kristen J. Brennand
    •  & Laura M. Huckins

News & Comment

  • Editorial |

    In this special issue, we present a series of reviews, perspectives and commentaries that highlight advances in methods and analytical approaches and provide guidelines and best practices in various areas of neuroscience.

  • News & Views |

    Network neuroscientists envision the brain as a network of nodes (regions) linked via edges (connections). A long-held assumption is that node-centric interactions are the primary phenomena of interest. Faskowitz et al. introduce a novel edge-centric framework with the potential to usher in a new era of discovery in connectomics research.

    • Lucina Q. Uddin
  • News & Views |

    Chiot and colleagues investigated whether peripheral macrophages play a role in amyotrophic lateral sclerosis (ALS) pathology, finding that macrophages along peripheral motor neuron axons react to neurodegeneration. Modifying reactive oxygen species (ROS) signaling in peripheral macrophages, using bone marrow cell replacement, reduces both macrophage and microglia inflammatory response, delays pathology and increases survival in ALS mouse models.

    • P. Hande Özdinler
  • News & Views |

    By building a richer behavioral vocabulary, Wiltschko et al. tease apart subtle differences in how pharmacological agents affect animal behavior, mapping on- and off-target effects of drugs with improved precision.

    • Ann Kennedy
  • News & Views |

    Abrupt spatial changes in anatomic and functional properties of the brain demarcate boundaries between discrete functional areas. While previous work has identified these boundaries in cortex, a new study by Tian et al. applies this approach for the first time to subcortical structures within the in vivo human brain.

    • Evan M. Gordon
  • News & Views |

    A new study shows that, immediately after axon injury, glycolysis is increased in Schwann cells to provide axons with energy and prevent them from degenerating. The authors also identify possible therapeutic targets that could be modulated to promote axonal protection.

    • Amelia Trimarco
    •  & Carla Taveggia