Julia Kuhl

Systems memory consolidation during sleep

Latest Research

  • Resource |

    This work describes comprehensive transcriptomic sequencing from murine thalamic pathways. By integrating this molecular information with anatomical and functional features, this study reveals a repeated architecture across thalamocortical systems.

    • James W. Phillips
    • , Anton Schulmann
    • , Erina Hara
    • , Johan Winnubst
    • , Chenghao Liu
    • , Vera Valakh
    • , Lihua Wang
    • , Brenda C. Shields
    • , Wyatt Korff
    • , Jayaram Chandrashekar
    • , Andrew L. Lemire
    • , Brett Mensh
    • , Joshua T. Dudman
    • , Sacha B. Nelson
    •  & Adam W. Hantman
  • Resource |

    Multi-omic analyses of transcriptional, chromatin occupancy and chromatin interaction dynamics in hippocampal excitatory neurons of adult mice upon activation by status epilepticus or novel context exploration reveals short- and long-lasting changes.

    • Jordi Fernandez-Albert
    • , Michal Lipinski
    • , María T. Lopez-Cascales
    • , M. Jordan Rowley
    • , Ana M. Martin-Gonzalez
    • , Beatriz del Blanco
    • , Victor G. Corces
    •  & Angel Barco
  • Technical Report |

    Fecher et al. devise an approach to isolate cell-type-specific mitochondria from the mouse CNS. They demonstrate proteomic diversity of cerebellar mitochondria covering bioenergetics, calcium handling and organelle contact sites.

    • Caroline Fecher
    • , Laura Trovò
    • , Stephan A. Müller
    • , Nicolas Snaidero
    • , Jennifer Wettmarshausen
    • , Sylvia Heink
    • , Oskar Ortiz
    • , Ingrid Wagner
    • , Ralf Kühn
    • , Jana Hartmann
    • , Rosa Maria Karl
    • , Arthur Konnerth
    • , Thomas Korn
    • , Wolfgang Wurst
    • , Doron Merkler
    • , Stefan F. Lichtenthaler
    • , Fabiana Perocchi
    •  & Thomas Misgeld
  • Article |

    Huang and colleagues functionally map a brain circuit connecting the amygdala and the spinal cord that is altered after nerve injury and contributes to chronic pain.

    • Junting Huang
    • , Vinicius M. Gadotti
    • , Lina Chen
    • , Ivana A. Souza
    • , Shuo Huang
    • , Decheng Wang
    • , Charu Ramakrishnan
    • , Karl Deisseroth
    • , Zizhen Zhang
    •  & Gerald W. Zamponi

News & Comment

  • News & Views |

    A new study sheds light on how sensitivity to communication sounds is established in the brain. Juvenile finches raised with tutors of either the same or different species always learned the tutors’ songs. Cortical neurons developed selectivity for the learned song by tuning for its secondary acoustic features.

    • Aaron Williams
    •  & Maria N. Geffen
  • News & Views |

    Chronic pain is associated with anxio-depressive comorbidities, but the neuroanatomical substrates remain unknown. A specific serotonergic pathway from the dorsal raphe nucleus to the lateral habenula via the central amygdala is now uncovered as a key neural circuit governing comorbid depressive symptoms in chronic pain.

    • Anke Tappe-Theodor
    •  & Rohini Kuner
  • News & Views |

    Repeat-associated non-AUG (RAN) translation generates toxic repeat proteins from pathological repeat expansions found in certain neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal dementia. How to suppress RAN translation has so far been unknown. A new study now reports a selective regulator of RAN translation identified in a genetic screen in yeast.

    • Saskia Hutten
    •  & Dorothee Dormann
  • News & Views |

    Misfolded protein aggregates are a classical hallmark of many neurodegenerative diseases. By combining a mouse model of misfolded protein injection and a brain network model of misfolded protein diffusion, a study now finds a strong link between the stereotypical spreading patterns of neurodegeneration, protein expression and anatomical connectivity.

    • Ellen Kuhl
  • News & Views |

    Mosquito-borne virus infections, such as West Nile and Zika, have debilitating cognitive effects that persist despite recovery from encephalitis. Garber et al. identify mechanisms by which antiviral T cell persistence after recovery from infection leads to impairments in cognition via virus-specific mediation of microglial synapse elimination.

    • Karen Krukowski
    •  & Susanna Rosi
  • Q&A |

    There is disagreement on how best to define and investigate fear. Nature Neuroscience asked Dean Mobbs to lead experts from the fields of human and animal affective neuroscience to discuss their viewpoints on how to define fear and how to move forward with the study of fear.

    • Dean Mobbs
    • , Ralph Adolphs
    • , Michael S. Fanselow
    • , Lisa Feldman Barrett
    • , Joseph E. LeDoux
    • , Kerry Ressler
    •  & Kay M. Tye

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