GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Latest Research

  • Review Article |

    Knowledge of the role of glial–neuronal interactions in the physiology of food intake and energy metabolism is emerging. This review highlights the role of astrocytes, microglia, and tanycytes in central control of systemic metabolism.

    • Cristina García-Cáceres
    • , Eglantine Balland
    • , Vincent Prevot
    • , Serge Luquet
    • , Stephen C. Woods
    • , Marco Koch
    • , Tamas L. Horvath
    • , Chun-Xia Yi
    • , Julia A. Chowen
    • , Alexei Verkhratsky
    • , Alfonso Araque
    • , Ingo Bechmann
    •  & Matthias H. Tschöp
  • Review Article |

    A satisfactory understanding of how natural stimuli are encoded by neural circuits has remained elusive. Advances in machine learning provide new approaches to this problem by merging constraints imposed by stimulus statistics and behavioral goals.

    • Maxwell H. Turner
    • , Luis Gonzalo Sanchez Giraldo
    • , Odelia Schwartz
    •  & Fred Rieke
  • Article |

    How seizures emerge in epileptic brain remains an enigma. The authors show that the transition to seizure follows a ubiquitous dynamical principle inherent to many processes in nature characterized by repeated transitions between contrasting regimes.

    • Wei-Chih Chang
    • , Jan Kudlacek
    • , Jaroslav Hlinka
    • , Jan Chvojka
    • , Michal Hadrava
    • , Vojtech Kumpost
    • , Andrew D. Powell
    • , Radek Janca
    • , Matias I. Maturana
    • , Philippa J. Karoly
    • , Dean R. Freestone
    • , Mark J. Cook
    • , Milan Palus
    • , Jakub Otahal
    • , John G. R. Jefferys
    •  & Premysl Jiruska
  • Article |

    Many behavioral tasks require fast, reliable switching of the shape and duration of cortical activity. Stroud et al. show that modulation of neural excitability in recurrent network models provides flexible spatiotemporal control of neural activity.

    • Jake P. Stroud
    • , Mason A. Porter
    • , Guillaume Hennequin
    •  & Tim P. Vogels
  • Brief Communication |

    Herman et al. exploit the reliable effects of perturbing superior colliculus (SC) neuronal activity on perceptual choice behavior to demonstrate a plausible mechanism by which SC may contribute to perceptual judgments during covert attention tasks.

    • James P. Herman
    • , Leor N. Katz
    •  & Richard J. Krauzlis
  • Article |

    Lombardo et al. find large-scale associations between the leukocyte transcriptome and neural responses to speech in toddlers, and these associations differ between toddlers with ASD who have good versus poor language outcomes.

    • Michael V. Lombardo
    • , Tiziano Pramparo
    • , Vahid Gazestani
    • , Varun Warrier
    • , Richard A. I. Bethlehem
    • , Cynthia Carter Barnes
    • , Linda Lopez
    • , Nathan E. Lewis
    • , Lisa Eyler
    • , Karen Pierce
    •  & Eric Courchesne

News & Comment

  • News & Views |

    Landmark papers in 2005 and 2009 provided the first evidence of links between development, training, and white-matter plasticity in humans, contributing to a shift in our understanding of brain wiring that has inspired fundamental research into the role of genes, the environment, and the mechanisms underlying training-related plasticity.

    • Christopher J. Steele
    •  & Robert J. Zatorre
  • News & Views |

    In an unfamiliar situation, animals display variable choice behavior. Based on computational modeling and empirical data, a new study suggests that the variability in decision-making across individuals is driven by differences in internal neural dynamics in the medial frontal cortex.

    • Huriye Atilgan
    •  & Alex C. Kwan
  • News & Views |

    The combination of spinal epidural stimulation and physical therapy is restoring walking function to people with spinal cord injury. With intensive rehabilitation, some participants are able to walk in their communities during stimulation and even regain control over previously paralyzed movement in the absence of stimulation.

    • Chet Moritz
  • News & Views |

    Two recent studies have expanded our understanding of the circuits controlling urination: one described a projection from brainstem to spinal cord that relaxes the urethral sphincter, and the other revealed a subpopulation of brainstem-projecting layer 5 pyramidal neurons in primary motor cortex that direct the initiation of urination.

    • Zheyi Ni
    •  & Hailan Hu
  • News & Views |

    What you choose depends on what information your brain considers and what it neglects when computing the value of actions. An early theory used this insight for a computational account of habits versus deliberation. It has ultimately helped uncover how choice in the brain goes beyond such simple dichotomies.

    • Nathaniel D. Daw
  • News & Views |

    A new theory derives the sequential nature of hippocampal replay from first principles and, moreover, predicts the specific patterns of replay that are actually observed in multiple different experiments.

    • John Widloski
    •  & David J. Foster

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