Reviews & Analysis

No effective therapies exist for dry age-related macular degeneration. In this perspective, the authors propose that research should emphasize system biology approaches that integrate various ‘omics’ data into mathematical models to establish pathogenic mechanisms on which to design novel treatments, and identify biomarkers that predict disease progression and therapeutic response.

Glycomics is gaining momentum in basic, translational and clinical research. Here, the authors review current reporting standards and analysis tools for mass-spectrometry-based glycomics, and propose an e-infrastructure for standardized reporting and online deposition of glycomics data.

While natural gas and fossil fuels power human activities, increasing concerns over fuel reserves and environmental impacts require finding alternative, renewable resources. Here, authors review the fundamental science and progress on solar-powered conversion of carbon dioxide to methane.

Lack of best practice guidelines currently limits the application of metabolomics in the regulatory sciences. Here, the MEtabolomics standaRds Initiative in Toxicology (MERIT) proposes methods and reporting standards for several important applications of metabolomics in regulatory toxicology.

There are several lines of evidence for interactions between the two membrane leaflets in cells. In this review the authors discuss the transmembrane coupling of lipids, the involvement of phosphatidyl serine species PS 18:0/18:1, and their importance for various cellular processes.

Hurricane Maria hit Puerto Rico in 2017 and resulted in a complete loss of activity of the Public Health Laboratories. Here, the authors discuss the approach taken and tools developed to re-establish activity in these laboratories using a quality management system and the lessons learned in this process.

Questions of causality are ubiquitous in Earth system sciences and beyond, yet correlation techniques still prevail. This Perspective provides an overview of causal inference methods, identifies promising applications and methodological challenges, and initiates a causality benchmark platform.

The reciprocal interaction between genetic and cultural evolution is well recognised in humans. Here, Whitehead and colleagues review the growing body of evidence that culture is also a major driver of both neutral and adaptive genetic evolution in non-human animals.

Cellular mechanical stress is a key determinant of cell shape and function, but how the cell senses stress direction is unclear. In this Perspective the authors propose that microtubules autonomously sense stress directions in plant cells, where tensile stresses are higher than in animal cells.

Engineering microbial cell factories for the production of useful plant natural products (PNPs) is a resource-conserving and environmentally-friendly synthesis route. Here, the authors review recent developments that enable engineering of hosts, pathways, and enzymes to make PNPs and PNP derivatives.

Immune cells adapt distinct metabolic strategies to accommodate specific functions associated with cell types or differentiation stages. Here in this review the authors discuss the nutrients, sensors, and mediators of such a metabolic adaption in nutrient-limiting immune microenvironments such as tumors or infections.

Pure organic molecules displaying room-temperature phosphorescence (RTP) are a rapidly emerging class of luminophores. In this Review, the authors discuss the principles for their rational design and development, from the underlying photophysical mechanisms of organic RTP, to enhancement and processing strategies for their practical application.

Climate change represents an existential, global threat to humanity, yet its delocalized nature complicates climate action. Here, the authors propose retrofitting air conditioning units as integrated, scalable, and renewable-powered devices capable of decentralized CO₂ conversion and energy democratization.

Generation of transgenic mice has become routine in studying gene function and disease mechanisms, but often this is not enough to fully understand human biology. Here, the authors review the current state of the art of targeted genomic humanisation strategies and their advantages over classic approaches.

Gadolinium(III) complexes are strong enhancers of magnetic resonance imaging (MRI) signals, thus are widely used as contrast agents despite their potential toxicity. Here, the authors review ligand design approaches aimed at improving the stability of Gd(III)-based MRI contrast agents.

Benchmarking studies are important for comprehensively understanding and evaluating different computational omics methods. Here, the authors review practices from 25 recent studies and propose principles to improve the quality of benchmarking studies.

The primary causes of dramatic variations in volcanic flux and composition along strike in subduction zones remain largely unknown. Here we use a promising new approach to show that along-strike volcanic variability in the Quaternary Cascades Arc is primarily due to variations in the flux of basalt into the base of the crust, rather than crustal magma storage.

Given the recent growing interest in interorganelle membrane contact sites, the field will benefit from clear rules to define and study them. In this Perspective, a panel of experts aims to provide this growing field with guidelines for experimental definition and analysis.

How can scientists and policymakers work together to reduce the health impacts of air pollution? In this review paper, the authors discuss the interplay between advances in environmental exposure assessment and policy advances to tackle pollution in a focused way.