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  • Here, the authors observe that laser illumination allows to displace a vial of nanoparticle solution over centimetre-scale distances. In order to explain this, they describe a novel mechanism for laser propulsion of a macroscopic object, based on light-induced thermophoresis.

    • Nikita Kavokine
    • Shuangyang Zou
    • Lydéric Bocquet
    Article Open Access
  • Intestinal aging is associated with declines in structure and absorption of nutrients. Here, the authors show that aging related intestinal decline is mediated by activation of the mTORC1-p38MAPK-p53 pathway in intestinal stem cells and can be ameliorated by abrogating mTORC1 or p38MAPK activity.

    • Dan He
    • Hongguang Wu
    • Baojie Li
    Article Open Access
  • It is interesting phenomenon that chiral order can emerge in intrinsically achiral liquid crystals. Here Čopar et al. demonstrate achiral-to-chiral transition of the nematic liquid crystals flow in microfluidic channels and their behaviour, stability, and dependence on geometric and material parameters.

    • Simon Čopar
    • Žiga Kos
    • Uroš Tkalec
    Article Open Access
  • Transition metal dichalcogenides demonstrate fascinating capabilities for electrocatalytic H2 evolution, although the activities vary widely depending on nanomaterial sites available. Here, authors show the grain boundaries of atomically thin MoS2 to be especially active sites for H2 evolution.

    • Yongmin He
    • Pengyi Tang
    • Zheng Liu
    Article Open Access
  • Though artificial sensory systems based on electronic devices have been realized, further transformation of data into spikes is required for neural network optimization. Here, based on NbOx Mott memristors, the authors report artificial spiking afferent nerves for accessing spiking systems and demonstrate spiking mechanoreceptor systems.

    • Xumeng Zhang
    • Ye Zhuo
    • J. Joshua Yang
    Article Open Access
  • Sertoli cells and other somatic cells of the testis comprise the germ cell niche and are critical to regulate spermatogenesis. Here the authors present a method in which Sertoli cells are selectively targeted for ablation by the compound benzalkonium chloride (BC) in mice, and the spermatogenic niche is subsequently repopulated in regions that have been affected by BC treatment.

    • Tetsuhiro Yokonishi
    • Jennifer McKey
    • Blanche Capel
    Article Open Access
  • Although artificial Lieb lattices have been recently synthesized, the realization of a Lieb lattice in a real material is still challenging. Here the authors use tight-binding and first principle calculations to predict tunable topology and magnetism in recently discovered two-dimensional covalent-organic frameworks.

    • Bin Cui
    • Xingwen Zheng
    • Bing Huang
    Article Open Access
  • Dietary fiber-derived short-chain fatty acids (SCFA) act as histone deacetylase (HDAC) inhibitors on Tregs and innate immune cells, promoting immune tolerance by altering gene expression. Here the authors show that SCFA HDAC inhibitor activity impacts B cell differentiation, antibody responses and antibody-driven autoimmunity.

    • Helia N. Sanchez
    • Justin B. Moroney
    • Paolo Casali
    Article Open Access
  • Little is known about the genetics of sclerosing stromal tumor of the ovary, a rare type of sex cord-stromal tumor. Here, the authors use sequencing strategies to show that in a cohort of 26 tumor samples 65% carry a FHL2-GLI2 fusion gene and demonstrate in vitro that the fusion gene has oncogenic properties.

    • Sarah H. Kim
    • Arnaud Da Cruz Paula
    • Britta Weigelt
    Article Open Access
  • Many intracellular pathogens mimic extracellular matrix motifs to specifically interact with the host membrane which may influences virus particle uptake. Here authors use single molecule tension sensors to reveal the minimal forces exerted on single virus particles and demonstrate that the uptake forces scale with the adhesion energy.

    • Tina Wiegand
    • Marta Fratini
    • Joachim P. Spatz
    Article Open Access
  • The physical origins of charge density waves in 1T-TiSe2 and their response to ultrafast excitation have long been a topic of theoretical and experimental debate. Here the authors present an ab initio theory that successfully captures the observed dynamics of charge density wave formation.

    • Chao Lian
    • Sheng-Jie Zhang
    • Sheng Meng
    Article Open Access
  • SnRK2 kinases activate abiotic stress responses in plants following ABA-dependent phosphatase inhibition or ABA-independent osmotic stress signalling. Here Takahashi et al. show that MAPKK-kinases phosphorylate and activate SnRK2s thus enabling robust ABA and osmotic stress signal transduction.

    • Yohei Takahashi
    • Jingbo Zhang
    • Julian I. Schroeder
    Article Open Access
  • The coding of sensory inputs at the level of vestibular sensory organs is not well understood. In this study, the authors demonstrate that the formation of striolar/central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated degradation of retinoic acid and show that Cyp26b1 cKO mice have abnormal vestibular evoked potentials and balance beam performance, but normal vestibular-ocular reflexes.

    • Kazuya Ono
    • James Keller
    • Doris K. Wu
    Article Open Access
  • DNA damage is associated with metabolic disorders, but the mechanism in unclear. Here, the authors show that persistent DNA damage induced by lack of the endonuclease XPF-ERCC1 triggers extracellular vesicle biogenesis in tissue infiltrating macrophages, and that vesicle uptake stimulates glucose uptake in recipient cells, leading to increased inflammation.

    • Evi Goulielmaki
    • Anna Ioannidou
    • George A. Garinis
    Article Open Access