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  • The benefit from immune checkpoint inhibitors is tempered by immunologic toxicities, which involve diverse organs, have varying biology, onset time, and severity. Herein, we identify important areas of controversy and open research questions in the field of immune-related toxicity.

    • Michael Conroy
    • Jarushka Naidoo
    CommentOpen Access
  • Among the existing machine learning frameworks, reservoir computing demonstrates fast and low-cost training, and its suitability for implementation in various physical systems. This Comment reports on how aspects of reservoir computing can be applied to classical forecasting methods to accelerate the learning process, and highlights a new approach that makes the hardware implementation of traditional machine learning algorithms practicable in electronic and photonic systems.

    • Lina Jaurigue
    • Kathy Lüdge
    CommentOpen Access
  • The protein corona is a key component controlling biological activity, that develops on foreign materials when introduced to biological environments. This comment discusses the risk of errors from poor methodology that can lead to misinterpretation and poor corona analysis which can impact diagnostic and clinical applications.

    • Morteza Mahmoudi
    CommentOpen Access