Articles

  • Article | | open

    The corneal endothelium is crucial for proper vision. Here, Ivarsdottir et al. perform genome-wide association studies for various corneal endothelial cell measurements and find that an intergenic variant near ANAPC1 explains 24% of the variance of endothelial cell density and associates with corneal hysteresis.

    • Erna V. Ivarsdottir
    • , Stefania Benonisdottir
    • , Gudmar Thorleifsson
    • , Patrick Sulem
    • , Asmundur Oddsson
    • , Unnur Styrkarsdottir
    • , Snaedis Kristmundsdottir
    • , Gudny A. Arnadottir
    • , Gudmundur Thorgeirsson
    • , Ingileif Jonsdottir
    • , Gunnar M. Zoega
    • , Unnur Thorsteinsdottir
    • , Daniel F. Gudbjartsson
    • , Fridbert Jonasson
    • , Hilma Holm
    •  & Kari Stefansson
  • Article | | open

    Although single atom catalysts (SACs) with high-loading metal-Nx have great potential in heterogeneous catalysis, their scalable synthesis remains challenging. Here, the authors develop a general cascade anchoring strategy for the mass production of a series of metal-Nx SACs with a metal loading up to 12.1 wt%.

    • Lu Zhao
    • , Yun Zhang
    • , Lin-Bo Huang
    • , Xiao-Zhi Liu
    • , Qing-Hua Zhang
    • , Chao He
    • , Ze-Yuan Wu
    • , Lin-Juan Zhang
    • , Jinpeng Wu
    • , Wanli Yang
    • , Lin Gu
    • , Jin-Song Hu
    •  & Li-Jun Wan
  • Article | | open

    The use of TIRF microscopy for DNA-PAINT experiments is limited by inhomogeneous illumination. Here the authors show that quantitative analysis of single-molecule TIRF experiments can be improved by using a segment-wise analysis approach and overcome by using a beam-shaping device to give a flat-top illumination profile.

    • Florian Stehr
    • , Johannes Stein
    • , Florian Schueder
    • , Petra Schwille
    •  & Ralf Jungmann
  • Article | | open

    The nature of non-saturating magnetoresistance (MR) in topological materials is an important issue in condensed matter research but remains elusive. The authors here report the nonlinear MR at room temperature in WTe2 with temperature-driven inversion due to the temperature-induced changes in Fermi surface convexity.

    • Pan He
    • , Chuang-Han Hsu
    • , Shuyuan Shi
    • , Kaiming Cai
    • , Junyong Wang
    • , Qisheng Wang
    • , Goki Eda
    • , Hsin Lin
    • , Vitor M. Pereira
    •  & Hyunsoo Yang
  • Article | | open

    CdS nanostructures can enable memory based photodetection by charge-storage accumulative effect. Here, the authors report CdS nanoribbons-based memory phototransistors with high responsivity of 3.8 × 109 A/W and detectivity of 7.7 × 1022 Jones that can detect weak light of 6 nW/cm2.

    • Zhibin Shao
    • , Tianhao Jiang
    • , Xiujuan Zhang
    • , Xiaohong Zhang
    • , Xiaofeng Wu
    • , Feifei Xia
    • , Shiyun Xiong
    • , Shuit-Tong Lee
    •  & Jiansheng Jie
  • Article | | open

    The effect of fluid viscosity on fault mechanics is mainly conjectured by theoretical models. Here, the authors present experimental data from rock friction experiments, showing both static and dynamic friction coefficients to decrease with viscosity and dynamic friction to depend on the Sommerfeld number.

    • C. Cornelio
    • , E. Spagnuolo
    • , G. Di Toro
    • , S. Nielsen
    •  & M. Violay
  • Article | | open

    Immunoglobulin Light Chain Amyloidosis (AL) is the most common systemic amyloidosis occurring in Western countries. Here the authors present the 4.0 Å cryo-EM structure of light chain AL55 fibrils that were isolated from the heart of an AL systemic amyloidosis patient.

    • Paolo Swuec
    • , Francesca Lavatelli
    • , Masayoshi Tasaki
    • , Cristina Paissoni
    • , Paola Rognoni
    • , Martina Maritan
    • , Francesca Brambilla
    • , Paolo Milani
    • , Pierluigi Mauri
    • , Carlo Camilloni
    • , Giovanni Palladini
    • , Giampaolo Merlini
    • , Stefano Ricagno
    •  & Martino Bolognesi
  • Article | | open

    The response time of North Atlantic climate to changes in high-latitude deep-water formation during the last deglaciation is still unclear. Here the authors show that gradual changes in Nordic Seas deep-water circulation systematically lead ahead of abrupt regional climate shifts by ~400 years.

    • Francesco Muschitiello
    • , William J. D’Andrea
    • , Andreas Schmittner
    • , Timothy J. Heaton
    • , Nicholas L. Balascio
    • , Nicole deRoberts
    • , Marc W. Caffee
    • , Thomas E. Woodruff
    • , Kees C. Welten
    • , Luke C. Skinner
    • , Margit H. Simon
    •  & Trond M. Dokken
  • Article | | open

    Separating anthropogenic and climatic impacts on forest compositions can be challenging due to a lack of data. Here the authors look at forest compositional changes in eastern Canada since the 19th century and find land use has most strongly shaped communities towards disturbance-adapted species.

    • Victor Danneyrolles
    • , Sébastien Dupuis
    • , Gabriel Fortin
    • , Marie Leroyer
    • , André de Römer
    • , Raphaële Terrail
    • , Mark Vellend
    • , Yan Boucher
    • , Jason Laflamme
    • , Yves Bergeron
    •  & Dominique Arseneault
  • Article | | open

    Systemic AL amyloidosis is caused by misfolding of immunoglobulin light chains and is one of the most frequently occurring forms of systemic amyloidosis. Here the authors present the 3.3 Å cryo-EM structure of a λ1 AL amyloid fibril that was isolated from an explanted human heart.

    • Lynn Radamaker
    • , Yin-Hsi Lin
    • , Karthikeyan Annamalai
    • , Stefanie Huhn
    • , Ute Hegenbart
    • , Stefan O. Schönland
    • , Günter Fritz
    • , Matthias Schmidt
    •  & Marcus Fändrich
  • Article | | open

    T-cell function impairment is one of the major determinants of tumour immune evasion. Here, the authors show that the hostile conditions in the tumour microenvironment lead to C/EBP homologous-protein upregulation in T cells via ER stress, resulting in repression of T-bet and consequent inhibition of CD8+ T cell function.”

    • Yu Cao
    • , Jimena Trillo-Tinoco
    • , Rosa A. Sierra
    • , Carmen Anadon
    • , Wenjie Dai
    • , Eslam Mohamed
    • , Ling Cen
    • , Tara L. Costich
    • , Anthony Magliocco
    • , Douglas Marchion
    • , Richard Klar
    • , Sven Michel
    • , Frank Jaschinski
    • , Richard R. Reich
    • , Shikhar Mehrotra
    • , Juan R. Cubillos-Ruiz
    • , David H. Munn
    • , Jose R. Conejo-Garcia
    •  & Paulo C. Rodriguez
  • Article | | open

    Proteins continuously undergo non-enzymatic modifications such as glycation, which accumulate under physiological conditions but can be enhanced in disease. Here the authors characterise histone glycation, provide evidence that it affects chromatin, particularly in breast cancer, and identify DJ-1 as a deglycase.

    • Qingfei Zheng
    • , Nathaniel D. Omans
    • , Rachel Leicher
    • , Adewola Osunsade
    • , Albert S. Agustinus
    • , Efrat Finkin-Groner
    • , Hannah D’Ambrosio
    • , Bo Liu
    • , Sarat Chandarlapaty
    • , Shixin Liu
    •  & Yael David
  • Article | | open

    ABCB1 encodes Multidrug Resistance Protein which promotes efflux of chemotherapeutic and targeted agents. Here, in breast and ovarian cancer the authors identify multiple transcriptional fusion partners involving ABCB1 that are associated with treatment failure and previous treatment regimens.

    • Elizabeth L. Christie
    • , Swetansu Pattnaik
    • , Jessica Beach
    • , Anthony Copeland
    • , Nineveh Rashoo
    • , Sian Fereday
    • , Joy Hendley
    • , Kathryn Alsop
    • , Samuel L. Brady
    • , Greg Lamb
    • , Ahwan Pandey
    • , Anna deFazio
    • , Heather Thorne
    • , Andrea Bild
    •  & David D. L. Bowtell
  • Article | | open

    Despite the progress in C(sp3) cross-coupling reactions, full control over the stereochemistry remains a challenge. Here, the authors show that phosphine-containing axially shielded Pd(II) complexes enable Suzuki-Miyaura cross-couplings of unactivated C(sp3) boronic acids with perfect stereoretention.

    • Jonathan W. Lehmann
    • , Ian T. Crouch
    • , Daniel J. Blair
    • , Melanie Trobe
    • , Pulin Wang
    • , Junqi Li
    •  & Martin D. Burke
  • Article | | open

    Anammox bacteria couple nitrite reduction to ammonium oxidation, with nitric oxide (NO) and hydrazine as intermediates, and produce N2 and nitrate. Here, Hu et al. show that an anammox bacterium can grow in the absence of nitrite by coupling ammonium oxidation to NO reduction, producing only N2.

    • Ziye Hu
    • , Hans J. C. T. Wessels
    • , Theo van Alen
    • , Mike S. M. Jetten
    •  & Boran Kartal
  • Article | | open

    Some microorganisms may be transferred across the food production chain and, potentially, colonize the human gut. Here, Milani et al. provide strain-level evidence supporting that dairy cattle-associated bacteria can be transferred to the human gut via consumption of Parmesan cheese.

    • Christian Milani
    • , Sabrina Duranti
    • , Stefania Napoli
    • , Giulia Alessandri
    • , Leonardo Mancabelli
    • , Rosaria Anzalone
    • , Giulia Longhi
    • , Alice Viappiani
    • , Marta Mangifesta
    • , Gabriele Andrea Lugli
    • , Sergio Bernasconi
    • , Maria Cristina Ossiprandi
    • , Douwe van Sinderen
    • , Marco Ventura
    •  & Francesca Turroni
  • Article | | open

    Chromatin structure plays a significant role in the regulation of gene expression. Here the authors show that TFIIH interacts with the histone acetyl transferase KAT2A and recruits the ATAC/hSAGA complexes to chromatin; and that loss of xeroderma pigmentosum group B (XPB) function results in chromatin decondensation and increased gene expression through activation of KAT2A.

    • Jérémy Sandoz
    • , Zita Nagy
    • , Philippe Catez
    • , Gizem Caliskan
    • , Sylvain Geny
    • , Jean-Baptiste Renaud
    • , Jean-Paul Concordet
    • , Arnaud Poterszman
    • , Laszlo Tora
    • , Jean-Marc Egly
    • , Nicolas Le May
    •  & Frédéric Coin
  • Article | | open

    TIRF imaging is limited by the size and uniformity of the illumination. Here the authors present a waveguide solution to create a large area of uniform evanescent illumination suitable for single molecule imaging coupled with a customised sample holder containing a reservoir for DNA-PAINT solutions.

    • Anna Archetti
    • , Evgenii Glushkov
    • , Christian Sieben
    • , Anton Stroganov
    • , Aleksandra Radenovic
    •  & Suliana Manley
  • Article | | open

    Hsp90 is a molecular chaperone that acts together with co-chaperones to ensure folding and activation of many client proteins. Here authors show that a N-terminal motif in Aha-type co-chaperones modulates the apparent affinity of Hsp90 for nucleotide substrates.

    • Rebecca Mercier
    • , Annemarie Wolmarans
    • , Jonathan Schubert
    • , Hannes Neuweiler
    • , Jill L. Johnson
    •  & Paul LaPointe
  • Article | | open

    While the role of effective population size (Ne) in explaining variation in genetic diversity has received much attention, the role of spontaneous mutation rate is largely ignored. Here, Xu et al. show that giant duckweed has a high Ne yet low genetic diversity, likely due to its low mutation rate.

    • Shuqing Xu
    • , Jessica Stapley
    • , Saskia Gablenz
    • , Justin Boyer
    • , Klaus J. Appenroth
    • , K. Sowjanya Sree
    • , Jonathan Gershenzon
    • , Alex Widmer
    •  & Meret Huber
  • Article | | open

    Studying adrenergic signalling in the heart requires perfusion with receptor agonists, which lacks cell specificity and spatiotemporal control. Here the authors use the light sensitive G-coupled receptor JellyOp to optogenetically control Gs-signaling in cardiomyocytes and intact hearts with high spatiotemporal precision.

    • Philipp Makowka
    • , Tobias Bruegmann
    • , Vanessa Dusend
    • , Daniela Malan
    • , Thomas Beiert
    • , Michael Hesse
    • , Bernd K. Fleischmann
    •  & Philipp Sasse
  • Article | | open

    The fossil record of the reproductive traits of early birds is limited. Here, Bailleul and colleagues describe the Cretaceous enantiornithine bird Avimaia schweitzerae, which preserves an unlaid egg in the abdominal cavity and putative medullary bone.

    • Alida M. Bailleul
    • , Jingmai O’Connor
    • , Shukang Zhang
    • , Zhiheng Li
    • , Qiang Wang
    • , Matthew C. Lamanna
    • , Xufeng Zhu
    •  & Zhonghe Zhou
  • Article | | open

    Bacteria grown on two carbon sources either consume both sources simultaneously or consume them sequentially. Here the authors use a metabolic network model of E. coli to show that optimal protein resource allocation and topological features of the network can explain the choice of carbon acquisition.

    • Xin Wang
    • , Kang Xia
    • , Xiaojing Yang
    •  & Chao Tang
  • Article | | open

    We are currently short of methods that can extract objective parameters of dendritic spines useful for their categorization. Authors present in this study an automatic analytical pipeline for spine geometry using 3D-structured illumination microscopy, which can effectively extract many geometrical parameters of dendritic spines without bias and automatically categorize spine population based on their morphological features

    • Yutaro Kashiwagi
    • , Takahito Higashi
    • , Kazuki Obashi
    • , Yuka Sato
    • , Noboru H. Komiyama
    • , Seth G. N. Grant
    •  & Shigeo Okabe
  • Article | | open

    Coral bleaching is generally linked to higher sea temperatures, but there may be geographic variation in this effect. Here, in a synthesis of global coral bleaching data, the authors show that bleaching probability is highest at mid-latitude sites despite equivalent thermal stress at equatorial sites.

    • S. Sully
    • , D. E. Burkepile
    • , M. K. Donovan
    • , G. Hodgson
    •  & R. van Woesik
  • Article | | open

    Piezoresponse force microscopy (PFM) is widely used to study piezoelectric properties of materials. Here, the authors not only show that PFM measurements will yield a signal even in non-piezoelectric materials via induced flexoelectricity, but also introduce a protocol to distinguish these from real signals.

    • Amir Abdollahi
    • , Neus Domingo
    • , Irene Arias
    •  & Gustau Catalan
  • Article | | open

    Two dimensional halide perovskites solar cells have attracted research interest due to their higher stability compared to three dimensional counterparts. Here Hu et al. show that fine tuning of the chemical structure of the spacer cations leads to different packing arrangements and device efficiency.

    • Jun Hu
    • , Iain W. H. Oswald
    • , Samuel J. Stuard
    • , Masrur Morshed Nahid
    • , Ninghao Zhou
    • , Olivia F. Williams
    • , Zhenkun Guo
    • , Liang Yan
    • , Huamin Hu
    • , Zheng Chen
    • , Xun Xiao
    • , Yun Lin
    • , Zhibin Yang
    • , Jinsong Huang
    • , Andrew M. Moran
    • , Harald Ade
    • , James R. Neilson
    •  & Wei You
  • Article | | open

    The use of ferroeletric materials for multi-state device applications is still challenging. Here, the authors present a mechanism to stabilize non-volatile polarization states by populating volume fractions of two domain structures in PbZr0.2Ti0.8O3 via kinetic control of switching pathways.

    • R. Xu
    • , S. Liu
    • , S. Saremi
    • , R. Gao
    • , J. J. Wang
    • , Z. Hong
    • , H. Lu
    • , A. Ghosh
    • , S. Pandya
    • , E. Bonturim
    • , Z. H. Chen
    • , L. Q. Chen
    • , A. M. Rappe
    •  & L. W. Martin
  • Article | | open

    The mechanisms of paternal epigenetic inheritance and its influence on offspring are still poorly understood. Here the authors provide evidence that in C. elegans, sperm-inherited chromatin states influence transcription and cell identity in the germ cells of offspring.

    • Kiyomi Raye Kaneshiro
    • , Andreas Rechtsteiner
    •  & Susan Strome
  • Article | | open

    Gfi1b regulates cellularity of haematopoietic stem cells (HSCs) and megakaryocytes (MKs) as well as spreading of MKs on matrix. Here the authors show that Gfi1b regulates this behaviour by recruiting LSD1 and β-catenin to Wnt/β-catenin signalling targets.

    • Peiman Shooshtarizadeh
    • , Anne Helness
    • , Charles Vadnais
    • , Nelleke Brouwer
    • , Hugues Beauchemin
    • , Riyan Chen
    • , Halil Bagci
    • , Frank J. T. Staal
    • , Jean-François Coté
    •  & Tarik Möröy
  • Article | | open

    Phagocytosis of pathogens is thought to proceed through the sequential engagement of Fc-receptors on the phagocyte with antibodies on the target surface. Here authors show that myosin 1e and myosin 1f link the actin cytoskeleton to the membrane and are required for efficient phagocytosis of antibody-opsonized targets.

    • Sarah R. Barger
    • , Nicholas S. Reilly
    • , Maria S. Shutova
    • , Qingsen Li
    • , Paolo Maiuri
    • , John M. Heddleston
    • , Mark S. Mooseker
    • , Richard A. Flavell
    • , Tatyana Svitkina
    • , Patrick W. Oakes
    • , Mira Krendel
    •  & Nils C. Gauthier
  • Article | | open

    The intraseasonal barotropic response of the ocean has been assumed to be negligible in tropical regions. We show that boreal winter MJOs, aided by ocean stratification, trigger a significant basin-wide barotropic sea level response in the tropical Indian Ocean at intraseasonal time scales.

    • B. Rohith
    • , Arya Paul
    • , Fabien Durand
    • , Laurent Testut
    • , S. Prerna
    • , M. Afroosa
    • , S. S. V. S. Ramakrishna
    •  & S. S. C. Shenoi
  • Article | | open

    The transcriptional regulation of murine spermatogenesis is not well understood. Here, the authors use single-cell and bulk RNA-Sequencing of juvenile and adult mice to characterise somatic and germ cell development, and chromatin profile the X chromosome to show that spermatid-specific genes are repressed by H3K9me3 during meiosis.

    • Christina Ernst
    • , Nils Eling
    • , Celia P. Martinez-Jimenez
    • , John C. Marioni
    •  & Duncan T. Odom
  • Article | | open

    We can rapidly determine the gender, age and identity of a face, but the exact steps involved are unclear. Here, the authors show using magnetoencephalography (MEG) that gender and age are encoded in the brain before identity, and reveal the role of familiarity in the earliest stages of face processing.

    • Katharina Dobs
    • , Leyla Isik
    • , Dimitrios Pantazis
    •  & Nancy Kanwisher
  • Article | | open

    GWAS have identified numerous genetic loci for bone mineral density (BMD) and fracture risk. Here, the authors map these variants to putative target genes using ATAC-seq and Capture C of human osteoblasts and confirm ING3 and EPDR1 as BMD genes in in vitro osteoblast differentiation experiments.

    • Alessandra Chesi
    • , Yadav Wagley
    • , Matthew E. Johnson
    • , Elisabetta Manduchi
    • , Chun Su
    • , Sumei Lu
    • , Michelle E. Leonard
    • , Kenyaita M. Hodge
    • , James A. Pippin
    • , Kurt D. Hankenson
    • , Andrew D. Wells
    •  & Struan F. A. Grant
  • Article | | open

    Halogenase enzymes are of interest as halogenating tools for organic synthesis. Here the authors show that the bacterial FAD-dependent phenolic halogenase PltM chlorinates, brominates and iodinates a variety of substrates and reveal the structural basis for its substrate versatility and provide insights into the FAD recycling mechanism of PltM.

    • Shogo Mori
    • , Allan H. Pang
    • , Nishad Thamban Chandrika
    • , Sylvie Garneau-Tsodikova
    •  & Oleg V. Tsodikov
  • Article | | open

    Graphene oxide membranes have great potential in separation processes, but small ions rejection needs improvement for large scale applications. Here the authors manipulate the membrane’s surface charge to control selective ion transport, achieving high rejection for A2B and AB2 type salts and maintaining high water permeance.

    • Mengchen Zhang
    • , Kecheng Guan
    • , Yufan Ji
    • , Gongping Liu
    • , Wanqin Jin
    •  & Nanping Xu
  • Article | | open

    Vicinity of small bodies might be dangerous to the spacecrafts and to their instrumentation. Here the authors show the operational environment of asteroid Bennu, validate its photometric phase function and demonstrate the accelerating rotational rate due to YORP effect using the data acquired during the approach phase of OSIRIS-REx mission.

    • C. W. Hergenrother
    • , C. K. Maleszewski
    • , M. C. Nolan
    • , J.-Y. Li
    • , C. Y. Drouet d’Aubigny
    • , F. C. Shelly
    • , E. S. Howell
    • , T. R. Kareta
    • , M. R. M. Izawa
    • , M. A. Barucci
    • , E. B. Bierhaus
    • , H. Campins
    • , S. R. Chesley
    • , B. E. Clark
    • , E. J. Christensen
    • , D. N. DellaGiustina
    • , S. Fornasier
    • , D. R. Golish
    • , C. M. Hartzell
    • , B. Rizk
    • , D. J. Scheeres
    • , P. H. Smith
    • , X.-D. Zou
    • , D. S. Lauretta
    • , D. E. Highsmith
    • , J. Small
    • , D. Vokrouhlický
    • , N. E. Bowles
    • , E. Brown
    • , K. L. Donaldson Hanna
    • , T. Warren
    • , C. Brunet
    • , R. A. Chicoine
    • , S. Desjardins
    • , D. Gaudreau
    • , T. Haltigin
    • , S. Millington-Veloza
    • , A. Rubi
    • , J. Aponte
    • , N. Gorius
    • , A. Lunsford
    • , B. Allen
    • , J. Grindlay
    • , D. Guevel
    • , D. Hoak
    • , J. Hong
    • , D. L. Schrader
    • , J. Bayron
    • , O. Golubov
    • , P. Sánchez
    • , J. Stromberg
    • , M. Hirabayashi
    • , C. M. Hartzell
    • , S. Oliver
    • , M. Rascon
    • , A. Harch
    • , J. Joseph
    • , S. Squyres
    • , D. Richardson
    • , J. P. Emery
    • , L. McGraw
    • , R. Ghent
    • , R. P. Binzel
    • , M. M. Al Asad
    • , C. L. Johnson
    • , L. Philpott
    • , H. C. M. Susorney
    • , E. A. Cloutis
    • , R. D. Hanna
    • , H. C. Connolly Jr.
    • , F. Ciceri
    • , A. R. Hildebrand
    • , E.-M. Ibrahim
    • , L. Breitenfeld
    • , T. Glotch
    • , A. D. Rogers
    • , B. E. Clark
    • , S. Ferrone
    • , C. A. Thomas
    • , H. Campins
    • , Y. Fernandez
    • , W. Chang
    • , A. Cheuvront
    • , D. Trang
    • , S. Tachibana
    • , H. Yurimoto
    • , J. R. Brucato
    • , G. Poggiali
    • , M. Pajola
    • , E. Dotto
    • , E. Mazzotta Epifani
    • , M. K. Crombie
    • , C. Lantz
    • , M. R. M. Izawa
    • , J. de Leon
    • , J. Licandro
    • , J. L. Rizos Garcia
    • , S. Clemett
    • , K. Thomas-Keprta
    • , S. Van wal
    • , M. Yoshikawa
    • , J. Bellerose
    • , S. Bhaskaran
    • , C. Boyles
    • , S. R. Chesley
    • , C. M. Elder
    • , D. Farnocchia
    • , A. Harbison
    • , B. Kennedy
    • , A. Knight
    • , N. Martinez-Vlasoff
    • , N. Mastrodemos
    • , T. McElrath
    • , W. Owen
    • , R. Park
    • , B. Rush
    • , L. Swanson
    • , Y. Takahashi
    • , D. Velez
    • , K. Yetter
    • , C. Thayer
    • , C. Adam
    • , P. Antreasian
    • , J. Bauman
    • , C. Bryan
    • , B. Carcich
    • , M. Corvin
    • , J. Geeraert
    • , J. Hoffman
    • , J. M. Leonard
    • , E. Lessac-Chenen
    • , A. Levine
    • , J. McAdams
    • , L. McCarthy
    • , D. Nelson
    • , B. Page
    • , J. Pelgrift
    • , E. Sahr
    • , K. Stakkestad
    • , D. Stanbridge
    • , D. Wibben
    • , B. Williams
    • , K. Williams
    • , P. Wolff
    • , P. Hayne
    • , D. Kubitschek
    • , M. A. Barucci
    • , J. D. P. Deshapriya
    • , S. Fornasier
    • , M. Fulchignoni
    • , P. Hasselmann
    • , F. Merlin
    • , A. Praet
    • , E. B. Bierhaus
    • , O. Billett
    • , A. Boggs
    • , B. Buck
    • , S. Carlson-Kelly
    • , J. Cerna
    • , K. Chaffin
    • , E. Church
    • , M. Coltrin
    • , J. Daly
    • , A. Deguzman
    • , R. Dubisher
    • , D. Eckart
    • , D. Ellis
    • , P. Falkenstern
    • , A. Fisher
    • , M. E. Fisher
    • , P. Fleming
    • , K. Fortney
    • , S. Francis
    • , S. Freund
    • , S. Gonzales
    • , P. Haas
    • , A. Hasten
    • , D. Hauf
    • , A. Hilbert
    • , D. Howell
    • , F. Jaen
    • , N. Jayakody
    • , M. Jenkins
    • , K. Johnson
    • , M. Lefevre
    • , H. Ma
    • , C. Mario
    • , K. Martin
    • , C. May
    • , M. McGee
    • , B. Miller
    • , C. Miller
    • , G. Miller
    • , A. Mirfakhrai
    • , E. Muhle
    • , C. Norman
    • , R. Olds
    • , C. Parish
    • , M. Ryle
    • , M. Schmitzer
    • , P. Sherman
    • , M. Skeen
    • , M. Susak
    • , B. Sutter
    • , Q. Tran
    • , C. Welch
    • , R. Witherspoon
    • , J. Wood
    • , J. Zareski
    • , M. Arvizu-Jakubicki
    • , E. Asphaug
    • , E. Audi
    • , R.-L. Ballouz
    • , R. Bandrowski
    • , K. J. Becker
    • , T. L. Becker
    • , S. Bendall
    • , C. A. Bennett
    • , H. Bloomenthal
    • , D. Blum
    • , W. V. Boynton
    • , J. Brodbeck
    • , K. N. Burke
    • , M. Chojnacki
    • , A. Colpo
    • , J. Contreras
    • , J. Cutts
    • , C. Y. Drouet d’Aubigny
    • , D. Dean
    • , D. N. DellaGiustina
    • , B. Diallo
    • , D. Drinnon
    • , K. Drozd
    • , H. L. Enos
    • , R. Enos
    • , C. Fellows
    • , T. Ferro
    • , M. R. Fisher
    • , G. Fitzgibbon
    • , M. Fitzgibbon
    • , J. Forelli
    • , T. Forrester
    • , I. Galinsky
    • , R. Garcia
    • , A. Gardner
    • , D. R. Golish
    • , N. Habib
    • , D. Hamara
    • , D. Hammond
    • , K. Hanley
    • , K. Harshman
    • , C. W. Hergenrother
    • , K. Herzog
    • , D. Hill
    • , C. Hoekenga
    • , S. Hooven
    • , E. S. Howell
    • , E. Huettner
    • , A. Janakus
    • , J. Jones
    • , T. R. Kareta
    • , J. Kidd
    • , K. Kingsbury
    • , S. S. Balram-Knutson
    • , L. Koelbel
    • , J. Kreiner
    • , D. Lambert
    • , D. S. Lauretta
    • , C. Lewin
    • , B. Lovelace
    • , M. Loveridge
    • , M. Lujan
    • , C. K. Maleszewski
    • , R. Malhotra
    • , K. Marchese
    • , E. McDonough
    • , N. Mogk
    • , V. Morrison
    • , E. Morton
    • , R. Munoz
    • , J. Nelson
    • , M. C. Nolan
    • , J. Padilla
    • , R. Pennington
    • , A. Polit
    • , N. Ramos
    • , V. Reddy
    • , M. Riehl
    • , B. Rizk
    • , H. L. Roper
    • , S. Salazar
    • , S. R. Schwartz
    • , S. Selznick
    • , N. Shultz
    • , P. H. Smith
    • , S. Stewart
    • , S. Sutton
    • , T. Swindle
    • , Y. H. Tang
    • , M. Westermann
    • , C. W. V. Wolner
    • , D. Worden
    • , T. Zega
    • , Z. Zeszut
    • , A. Bjurstrom
    • , L. Bloomquist
    • , C. Dickinson
    • , E. Keates
    • , J. Liang
    • , V. Nifo
    • , A. Taylor
    • , F. Teti
    • , M. Caplinger
    • , H. Bowles
    • , S. Carter
    • , S. Dickenshied
    • , D. Doerres
    • , T. Fisher
    • , W. Hagee
    • , J. Hill
    • , M. Miner
    • , D. Noss
    • , N. Piacentine
    • , M. Smith
    • , A. Toland
    • , P. Wren
    • , M. Bernacki
    • , D. Pino Munoz
    • , S.-i. Watanabe
    • , S. A. Sandford
    • , A. Aqueche
    • , B. Ashman
    • , M. Barker
    • , A. Bartels
    • , K. Berry
    • , B. Bos
    • , R. Burns
    • , A. Calloway
    • , R. Carpenter
    • , N. Castro
    • , R. Cosentino
    • , J. Donaldson
    • , J. P. Dworkin
    • , J. Elsila Cook
    • , C. Emr
    • , D. Everett
    • , D. Fennell
    • , K. Fleshman
    • , D. Folta
    • , D. Gallagher
    • , J. Garvin
    • , K. Getzandanner
    • , D. Glavin
    • , S. Hull
    • , K. Hyde
    • , H. Ido
    • , A. Ingegneri
    • , N. Jones
    • , P. Kaotira
    • , L. F. Lim
    • , A. Liounis
    • , C. Lorentson
    • , D. Lorenz
    • , J. Lyzhoft
    • , E. M. Mazarico
    • , R. Mink
    • , W. Moore
    • , M. Moreau
    • , S. Mullen
    • , J. Nagy
    • , G. Neumann
    • , J. Nuth
    • , D. Poland
    • , D. C. Reuter
    • , L. Rhoads
    • , S. Rieger
    • , D. Rowlands
    • , D. Sallitt
    • , A. Scroggins
    • , G. Shaw
    • , A. A. Simon
    • , J. Swenson
    • , P. Vasudeva
    • , M. Wasser
    • , R. Zellar
    • , J. Grossman
    • , G. Johnston
    • , M. Morris
    • , J. Wendel
    • , A. Burton
    • , L. P. Keller
    • , L. McNamara
    • , S. Messenger
    • , K. Nakamura-Messenger
    • , A. Nguyen
    • , K. Righter
    • , E. Queen
    • , K. Bellamy
    • , K. Dill
    • , S. Gardner
    • , M. Giuntini
    • , B. Key
    • , J. Kissell
    • , D. Patterson
    • , D. Vaughan
    • , B. Wright
    • , R. W. Gaskell
    • , L. Le Corre
    • , J.-Y. Li
    • , J. L. Molaro
    • , E. E. Palmer
    • , M. A. Siegler
    • , P. Tricarico
    • , J. R. Weirich
    • , X.-D. Zou
    • , T. Ireland
    • , K. Tait
    • , P. Bland
    • , S. Anwar
    • , N. Bojorquez-Murphy
    • , P. R. Christensen
    • , C. W. Haberle
    • , G. Mehall
    • , K. Rios
    • , I. Franchi
    • , B. Rozitis
    • , C. B. Beddingfield
    • , J. Marshall
    • , D. N. Brack
    • , A. S. French
    • , J. W. McMahon
    • , D. J. Scheeres
    • , E. R. Jawin
    • , T. J. McCoy
    • , S. Russell
    • , M. Killgore
    • , W. F. Bottke
    • , V. E. Hamilton
    • , H. H. Kaplan
    • , K. J. Walsh
    • , J. L. Bandfield
    • , B. C. Clark
    • , M. Chodas
    • , M. Lambert
    • , R. A. Masterson
    • , M. G. Daly
    • , J. Freemantle
    • , J. A. Seabrook
    • , O. S. Barnouin
    • , K. Craft
    • , R. T. Daly
    • , C. Ernst
    • , R. C. Espiritu
    • , M. Holdridge
    • , M. Jones
    • , A. H. Nair
    • , L. Nguyen
    • , J. Peachey
    • , M. E. Perry
    • , J. Plescia
    • , J. H. Roberts
    • , R. Steele
    • , R. Turner
    • , J. Backer
    • , K. Edmundson
    • , J. Mapel
    • , M. Milazzo
    • , S. Sides
    • , C. Manzoni
    • , B. May
    • , M. Delbo’
    • , G. Libourel
    • , P. Michel
    • , A. Ryan
    • , F. Thuillet
    •  & B. Marty
  • Article | | open

    Leaf-feeding insect microbiomes could be influenced by the soil, the plant, or a product of the two. Here, the authors conduct a series of experiments to show that an herbivorous insect predominantly acquires its microbiome from the soil rather than the plant, and that these insect microbiomes reflect soil legacies of earlier growing plants.

    • S. Emilia Hannula
    • , Feng Zhu
    • , Robin Heinen
    •  & T. Martijn Bezemer
  • Article | | open

    Lysine27-to-methionine mutations in histone H3 genes (H3K27M) occur in a subgroup of gliomas and decrease genome-wide H3K27 trimethylation. Here the authors utilise primary H3K27M tumour lines and isogenic CRISPR-edited controls and show that H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3.

    • Ashot S. Harutyunyan
    • , Brian Krug
    • , Haifen Chen
    • , Simon Papillon-Cavanagh
    • , Michele Zeinieh
    • , Nicolas De Jay
    • , Shriya Deshmukh
    • , Carol C. L. Chen
    • , Jad Belle
    • , Leonie G. Mikael
    • , Dylan M. Marchione
    • , Rui Li
    • , Hamid Nikbakht
    • , Bo Hu
    • , Gael Cagnone
    • , Warren A. Cheung
    • , Abdulshakour Mohammadnia
    • , Denise Bechet
    • , Damien Faury
    • , Melissa K McConechy
    • , Manav Pathania
    • , Siddhant U. Jain
    • , Benjamin Ellezam
    • , Alexander G. Weil
    • , Alexandre Montpetit
    • , Paolo Salomoni
    • , Tomi Pastinen
    • , Chao Lu
    • , Peter W. Lewis
    • , Benjamin A. Garcia
    • , Claudia L. Kleinman
    • , Nada Jabado
    •  & Jacek Majewski
  • Article | | open

    The cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind. Here, authors use a library of synthetic phosphopeptide analogues of the GPCR rhodopsin C-terminus and determine the ability of these peptides to bind and activate arrestins using a variety of biochemical and biophysical methods.

    • Daniel Mayer
    • , Fred F. Damberger
    • , Mamidi Samarasimhareddy
    • , Miki Feldmueller
    • , Ziva Vuckovic
    • , Tilman Flock
    • , Brian Bauer
    • , Eshita Mutt
    • , Franziska Zosel
    • , Frédéric H. T. Allain
    • , Jörg Standfuss
    • , Gebhard F. X. Schertler
    • , Xavier Deupi
    • , Martha E. Sommer
    • , Mattan Hurevich
    • , Assaf Friedler
    •  & Dmitry B. Veprintsev
  • Article | | open

    Central Anatolia harbored some of the earliest farming societies outside the Fertile Crescent of the Near East. Here, the authors report and analyze genome-wide data from a 15,000-year-old Anatolian hunter-gatherer and from seven Anatolian and Levantine early farmers, and suggest high genetic continuity between the hunter-gatherers and early farmers of Anatolia.

    • Michal Feldman
    • , Eva Fernández-Domínguez
    • , Luke Reynolds
    • , Douglas Baird
    • , Jessica Pearson
    • , Israel Hershkovitz
    • , Hila May
    • , Nigel Goring-Morris
    • , Marion Benz
    • , Julia Gresky
    • , Raffaela A. Bianco
    • , Andrew Fairbairn
    • , Gökhan Mustafaoğlu
    • , Philipp W. Stockhammer
    • , Cosimo Posth
    • , Wolfgang Haak
    • , Choongwon Jeong
    •  & Johannes Krause
  • Article | | open

    Tackling wildlife crimes requires determining their occurrence and distribution, but they are often difficult to detect. Here, the authors use hen harrier tracking data to show patterns of unexpected tag failure that suggest widespread illegal killing on moors managed for recreational shooting of red grouse.

    • Megan Murgatroyd
    • , Stephen M. Redpath
    • , Stephen G. Murphy
    • , David J. T. Douglas
    • , Richard Saunders
    •  & Arjun Amar
  • Article | | open

    Free electron lasers provide a state-of-the-art tool to investigate the photochemistry of water. Here, the authors show that highly rotationally excited hydroxyl radicals, so-called “super rotors” existing above the bond dissociation energy, are observed from the photodissociation of water, which may have implications for understanding the interstellar medium.

    • Yao Chang
    • , Yong Yu
    • , Heilong Wang
    • , Xixi Hu
    • , Qinming Li
    • , Jiayue Yang
    • , Shu Su
    • , Zhigang He
    • , Zhichao Chen
    • , Li Che
    • , Xingan Wang
    • , Weiqing Zhang
    • , Guorong Wu
    • , Daiqian Xie
    • , Michael N. R. Ashfold
    • , Kaijun Yuan
    •  & Xueming Yang
  • Article | | open

    It is unclear whether a constrictive force is exerted on the membrane from inside during bacterial cell division, or cell wall remodeling alone drives membrane constriction from outside. Here, the authors use simulations to explore different mechanisms for cell wall division, supporting that a constrictive force is required.

    • Lam T. Nguyen
    • , Catherine M. Oikonomou
    • , H. Jane Ding
    • , Mohammed Kaplan
    • , Qing Yao
    • , Yi-Wei Chang
    • , Morgan Beeby
    •  & Grant J. Jensen
  • Article | | open

    Somatic heterozygous TET2 loss drives clonal hematopoiesis, which is linked to malignant cell degeneration and potentially cardiovascular disease. Here, the authors investigate the molecular impact of a germline TET2 mutation in a lymphoma family, finding elevated blood DNA methylation levels and no predisposition to atherosclerosis

    • Eevi Kaasinen
    • , Outi Kuismin
    • , Kristiina Rajamäki
    • , Heikki Ristolainen
    • , Mervi Aavikko
    • , Johanna Kondelin
    • , Silva Saarinen
    • , Davide G. Berta
    • , Riku Katainen
    • , Elina A. M. Hirvonen
    • , Auli Karhu
    • , Aurora Taira
    • , Tomas Tanskanen
    • , Amjad Alkodsi
    • , Minna Taipale
    • , Ekaterina Morgunova
    • , Kaarle Franssila
    • , Rainer Lehtonen
    • , Markus Mäkinen
    • , Kristiina Aittomäki
    • , Aarno Palotie
    • , Mitja I. Kurki
    • , Olli Pietiläinen
    • , Morgane Hilpert
    • , Elmo Saarentaus
    • , Jaakko Niinimäki
    • , Juhani Junttila
    • , Kari Kaikkonen
    • , Pia Vahteristo
    • , Radek C. Skoda
    • , Mikko R. J. Seppänen
    • , Kari K. Eklund
    • , Jussi Taipale
    • , Outi Kilpivaara
    •  & Lauri A. Aaltonen
  • Article | | open

    Ufmylation is a ubiquitylation-like protein modification but only a few ufmylation substrates and functions have been discovered so far. Here, the authors demonstrate ufmylation of histone H4 upon DNA damage and show that this modification is involved in the amplification of ATM activation.

    • Bo Qin
    • , Jia Yu
    • , Somaira Nowsheen
    • , Minghui Wang
    • , Xinyi Tu
    • , Tongzheng Liu
    • , Honglin Li
    • , Liewei Wang
    •  & Zhenkun Lou
  • Article | | open

    Chronic infections of the fallopian tubes with Chlamydia trachomatis can cause scarring and infertility. Here, the authors show that the pathogen alters stem cell differentiation and DNA methylation in human fallopian tube organoids, suggesting a potential link to cellular ageing and malignant transformation.

    • Mirjana Kessler
    • , Karen Hoffmann
    • , Kristin Fritsche
    • , Volker Brinkmann
    • , Hans-Joachim Mollenkopf
    • , Oliver Thieck
    • , Ana Rita Teixeira da Costa
    • , Elena I. Braicu
    • , Jalid Sehouli
    • , Mandy Mangler
    • , Hilmar Berger
    •  & Thomas F. Meyer
  • Article | | open

    Clear cell renal cell carcinoma (ccRCC) is a urogenital cancer with a well-defined genetic landscape. Here, the authors analyse the clonal architecture of ccRCC patients from three populations, and find prognostic subtypes linked to immune infiltrates and clonal architecture.

    • Yi Huang
    • , Jiayin Wang
    • , Peilin Jia
    • , Xiangchun Li
    • , Guangsheng Pei
    • , Changxi Wang
    • , Xiaodong Fang
    • , Zhongming Zhao
    • , Zhiming Cai
    • , Xin Yi
    • , Song Wu
    •  & Baifeng Zhang
  • Article | | open

    Withdrawal from alcohol activates neurons in the central amygdala (CeA) and increases craving for alcohol. The authors show that these neurons predominantly express CRF and project to the BNST. Inactivation of this pathway reduces the dependence-related escalation of alcohol drinking.

    • Giordano de Guglielmo
    • , Marsida Kallupi
    • , Matthew B. Pomrenze
    • , Elena Crawford
    • , Sierra Simpson
    • , Paul Schweitzer
    • , George F. Koob
    • , Robert O. Messing
    •  & Olivier George