Articles

  • Article
    | Open Access

    Multiple quantum critical behaviors exist in the heavy fermion material CeRhIn5, but their interrelation is less studied. Here, Helm et al. investigate the interrelation of two quantum critical points and other relevant orders, revealing a strongly non-mean-field-like phase diagram.

    • Toni Helm
    • , Audrey D. Grockowiak
    • , Fedor F. Balakirev
    • , John Singleton
    • , Jonathan B. Betts
    • , Kent R. Shirer
    • , Markus König
    • , Tobias Förster
    • , Eric D. Bauer
    • , Filip Ronning
    • , Stanley W. Tozer
    •  & Philip J. W. Moll
  • Article
    | Open Access

    It is unclear whether 2D metal dichalcogenides (TMD) alone can cause ferroptotic cell death. Here, the authors show TMD nanosheets induced ferroptosis in mammalian cell lines and in a mouse model after aspiration of TMD materials into lungs, causing ferroptotic cell death.

    • Shujuan Xu
    • , Huizhen Zheng
    • , Ronglin Ma
    • , Di Wu
    • , Yanxia Pan
    • , Chunyang Yin
    • , Meng Gao
    • , Weili Wang
    • , Wei Li
    • , Sijin Liu
    • , Zhifang Chai
    •  & Ruibin Li
  • Article
    | Open Access

    Reliable, multiplexed gene editing to uncover synergies between targets remains challenging. Here, the authors engineer AsCas12a and the crRNA to improve double knockout for synthetic sick/lethal interaction genetic screening.

    • Rodrigo A. Gier
    • , Krista A. Budinich
    • , Niklaus H. Evitt
    • , Zhendong Cao
    • , Elizabeth S. Freilich
    • , Qingzhou Chen
    • , Jun Qi
    • , Yemin Lan
    • , Rahul M. Kohli
    •  & Junwei Shi
  • Article
    | Open Access

    Catalytic selectivity during carbon dioxide electroreduction can be tuned by using geometric copper-based catalysts. Here, the authors use liquid cell transmission electron microscopy to study the in situ synthesis and morphological evolution Cu2O cubes under carbon dioxide electroreduction conditions.

    • Rosa M. Arán-Ais
    • , Rubén Rizo
    • , Philipp Grosse
    • , Gerardo Algara-Siller
    • , Kassiogé Dembélé
    • , Milivoj Plodinec
    • , Thomas Lunkenbein
    • , See Wee Chee
    •  & Beatriz Roldan Cuenya
  • Article
    | Open Access

    The vCA1-BA projection is enriched in shock responsive neurons, which are necessary for fear memory encoding and become correlated with a network of neurons during retrieval. Here the authors show that the magnitude of vCA1 correlated activity is proportional to memory strength and requires the shock response during encoding.

    • Jessica C. Jimenez
    • , Jack E. Berry
    • , Sean C. Lim
    • , Samantha K. Ong
    • , Mazen A. Kheirbek
    •  & Rene Hen
  • Article
    | Open Access

    The global biodiversity decline might conceal complex local and group-specific trends. Here the authors report a quantitative synthesis of longterm biodiversity trends across Europe, showing how, despite overall increase in biodiversity metric and stability in abundance, trends differ between regions, ecosystem types, and taxa.

    • Francesca Pilotto
    • , Ingolf Kühn
    • , Rita Adrian
    • , Renate Alber
    • , Audrey Alignier
    • , Christopher Andrews
    • , Jaana Bäck
    • , Luc Barbaro
    • , Deborah Beaumont
    • , Natalie Beenaerts
    • , Sue Benham
    • , David S. Boukal
    • , Vincent Bretagnolle
    • , Elisa Camatti
    • , Roberto Canullo
    • , Patricia G. Cardoso
    • , Bruno J. Ens
    • , Gert Everaert
    • , Vesela Evtimova
    • , Heidrun Feuchtmayr
    • , Ricardo García-González
    • , Daniel Gómez García
    • , Ulf Grandin
    • , Jerzy M. Gutowski
    • , Liat Hadar
    • , Lubos Halada
    • , Melinda Halassy
    • , Herman Hummel
    • , Kaisa-Leena Huttunen
    • , Bogdan Jaroszewicz
    • , Thomas C. Jensen
    • , Henrik Kalivoda
    • , Inger Kappel Schmidt
    • , Ingrid Kröncke
    • , Reima Leinonen
    • , Filipe Martinho
    • , Henning Meesenburg
    • , Julia Meyer
    • , Stefano Minerbi
    • , Don Monteith
    • , Boris P. Nikolov
    • , Daniel Oro
    • , Dāvis Ozoliņš
    • , Bachisio M. Padedda
    • , Denise Pallett
    • , Marco Pansera
    • , Miguel Ângelo Pardal
    • , Bruno Petriccione
    • , Tanja Pipan
    • , Juha Pöyry
    • , Stefanie M. Schäfer
    • , Marcus Schaub
    • , Susanne C. Schneider
    • , Agnija Skuja
    • , Karline Soetaert
    • , Gunta Spriņģe
    • , Radoslav Stanchev
    • , Jenni A. Stockan
    • , Stefan Stoll
    • , Lisa Sundqvist
    • , Anne Thimonier
    • , Gert Van Hoey
    • , Gunther Van Ryckegem
    • , Marcel E. Visser
    • , Samuel Vorhauser
    •  & Peter Haase
  • Article
    | Open Access

    Genetic association studies have identified loci including the choline transporter SLC44A2 as a potential regulator of thrombosis. Here the authors report that loss of SLC44A2 impairs platelet activation and thrombosis in mice via a reduction of mitochondrial ATP production.

    • J. Allen Bennett
    • , Michael A. Mastrangelo
    • , Sara K. Ture
    • , Charles O. Smith
    • , Shannon G. Loelius
    • , Rachel A. Berg
    • , Xu Shi
    • , Ryan M. Burke
    • , Sherry L. Spinelli
    • , Scott J. Cameron
    • , Thomas E. Carey
    • , Paul S. Brookes
    • , Robert E. Gerszten
    • , Maria Sabater-Lleal
    • , Paul S. de Vries
    • , Jennifer E. Huffman
    • , Nicholas L. Smith
    • , Craig N. Morrell
    •  & Charles J. Lowenstein
  • Article
    | Open Access

    Deep learning is becoming a popular approach for understanding biological processes but can be hard to adapt to new questions. Here, the authors develop Janggu, a python library that aims to ease data acquisition and model evaluation and facilitate deep learning applications in genomics.

    • Wolfgang Kopp
    • , Remo Monti
    • , Annalaura Tamburrini
    • , Uwe Ohler
    •  & Altuna Akalin
  • Article
    | Open Access

    Exploration of high performance materials for lithium storage presents as a critical challenge. Here authors report micron-sized La0.5Li0.5TiO3 as a promising anode material, which demonstrates improved capacity, rate capability and suitable voltage as anode for lithium ion batteries.

    • Lu Zhang
    • , Xiaohua Zhang
    • , Guiying Tian
    • , Qinghua Zhang
    • , Michael Knapp
    • , Helmut Ehrenberg
    • , Gang Chen
    • , Zexiang Shen
    • , Guochun Yang
    • , Lin Gu
    •  & Fei Du
  • Article
    | Open Access

    In addition to paternal genetic material, sperm contributes epigenetic information to the embryo to efficiently support development. Here, the authors demonstrate a homogeneous paternal contribution to epigenetic information via sperm-derived modified histone transmission to the developing vertebrate embryo.

    • Mami Oikawa
    • , Angela Simeone
    • , Eva Hormanseder
    • , Marta Teperek
    • , Vincent Gaggioli
    • , Alan O’Doherty
    • , Emma Falk
    • , Matthieu Sporniak
    • , Clive D’Santos
    • , Valar Nila Roamio Franklin
    • , Kamal Kishore
    • , Charles R. Bradshaw
    • , Declan Keane
    • , Thomas Freour
    • , Laurent David
    • , Adrian T. Grzybowski
    • , Alexander J. Ruthenburg
    • , John Gurdon
    •  & Jerome Jullien
  • Article
    | Open Access

    Gene regulatory network inference is a topical problem in systems biology. Here, the authors presents BINGO, a powerful method for network inference from time series data.

    • Atte Aalto
    • , Lauri Viitasaari
    • , Pauliina Ilmonen
    • , Laurent Mombaerts
    •  & Jorge Gonçalves
  • Article
    | Open Access

    Photo-electrochemical reduction of carbon dioxide is a promising strategy to derive valuable products. Here, the authors show a photocathode able to produce carbon monoxide selectively in aqueous media with high activity using earth-abundant molecular catalyst.

    • Palas Baran Pati
    • , Ruwen Wang
    • , Etienne Boutin
    • , Stéphane Diring
    • , Stéphane Jobic
    • , Nicolas Barreau
    • , Fabrice Odobel
    •  & Marc Robert
  • Article
    | Open Access

    Cellular signalling networks provide information to the cell, but the trade-off between accuracy of information transfer and energetic cost of doing so has not been assessed. Here, the authors investigate a MAPK signalling cascade in budding yeast and find that information is maximised per unit energetic cost.

    • Alexander Anders
    • , Bhaswar Ghosh
    • , Timo Glatter
    •  & Victor Sourjik
  • Article
    | Open Access

    Melanosomes traffic along F-actin in melanocytes. Here, the authors show that Rab27a coordinates SPIRE/FMN actin assembly and MyoVa motor proteins to generate a cell-wide actin/myosin network that links melanosomes and allows the collective activity of these force generators to drive their traffic.

    • Noura Alzahofi
    • , Tobias Welz
    • , Christopher L. Robinson
    • , Emma L. Page
    • , Deborah A. Briggs
    • , Amy K. Stainthorp
    • , James Reekes
    • , David A. Elbe
    • , Felix Straub
    • , Wouter W. Kallemeijn
    • , Edward W. Tate
    • , Philip S. Goff
    • , Elena V. Sviderskaya
    • , Marta Cantero
    • , Lluis Montoliu
    • , Francois Nedelec
    • , Amanda K. Miles
    • , Maryse Bailly
    • , Eugen Kerkhoff
    •  & Alistair N. Hume
  • Article
    | Open Access

    Mice are able to discriminate colors, at least in the upper visual field. Here, the authors provide a comprehensive characterization of retinal circuits underlying this behavior.

    • Klaudia P. Szatko
    • , Maria M. Korympidou
    • , Yanli Ran
    • , Philipp Berens
    • , Deniz Dalkara
    • , Timm Schubert
    • , Thomas Euler
    •  & Katrin Franke
  • Article
    | Open Access

    Stable diradicals are generally based on two s/p-localized or π-delocalized unpaired electrons (radicals). Here, the authors report a dication diradical that is based on two SeSe three-electron σ-bonds.

    • Wenbang Yang
    • , Li Zhang
    • , Dengmengfei Xiao
    • , Rui Feng
    • , Wenqing Wang
    • , Sudip Pan
    • , Yue Zhao
    • , Lili Zhao
    • , Gernot Frenking
    •  & Xinping Wang
  • Article
    | Open Access

    While most results so far in semiconductor spin-based quantum computation use electron spins, devices based on hole spins may have more favourable properties for quantum applications. Here, the authors demonstrate single-shot readout and coherent control of a qubit made from a single hole spin.

    • N. W. Hendrickx
    • , W. I. L. Lawrie
    • , L. Petit
    • , A. Sammak
    • , G. Scappucci
    •  & M. Veldhorst
  • Article
    | Open Access

    PiggyBac is a transposon used in genome engineering that does not leave excision footprints. Here the authors determine the structures of two complexes in which the piggyBac transposase is bound to DNA representing different steps of the transposition reaction, providing a basis for how the transposition reaction proceeds.

    • Qiujia Chen
    • , Wentian Luo
    • , Ruth Ann Veach
    • , Alison B. Hickman
    • , Matthew H. Wilson
    •  & Fred Dyda
  • Article
    | Open Access

    DOCK2 is a guanine nucleotide exchange factor (GEF) that activates RHO GTPases and interacts with ELMO1, which stimulates its GEF activity. Here, the authors provide mechanistic insights into how ELMO1 regulates DOCK2 activity by determining the structure of the DOCK2–ELMO1 binary complex representing the closed, auto-inhibited state and the DOCK2−ELMO1−RAC1 ternary complex structure, where DOCK2−ELMO1 adopts an open, active conformation.

    • Leifu Chang
    • , Jing Yang
    • , Chang Hwa Jo
    • , Andreas Boland
    • , Ziguo Zhang
    • , Stephen H. McLaughlin
    • , Afnan Abu-Thuraia
    • , Ryan C. Killoran
    • , Matthew J. Smith
    • , Jean-Francois Côté
    •  & David Barford
  • Article
    | Open Access

    Genes that modulate the cytoskeleton have been associated with increased cell proliferation and migration. Here, the authors show that AVIL, an actin regulatory protein, is overexpressed in glioblastomas and mediates oncogenic effects through regulation of FOXM1 stability and LIN28B expression.

    • Zhongqiu Xie
    • , Pawel Ł. Janczyk
    • , Ying Zhang
    • , Aiqun Liu
    • , Xinrui Shi
    • , Sandeep Singh
    • , Loryn Facemire
    • , Kristopher Kubow
    • , Zi Li
    • , Yuemeng Jia
    • , Dorothy Schafer
    • , James W. Mandell
    • , Roger Abounader
    •  & Hui Li
  • Article
    | Open Access

    The nanoscale organisation of the brain extracellular space can be studied in vivo. Here, the authors investigate how it changes in response to α-synuclein pathology, and identify interactions between microglia and the extracellular matrix.

    • Federico N. Soria
    • , Chiara Paviolo
    • , Evelyne Doudnikoff
    • , Marie-Laure Arotcarena
    • , Antony Lee
    • , Noémie Danné
    • , Amit Kumar Mandal
    • , Philippe Gosset
    • , Benjamin Dehay
    • , Laurent Groc
    • , Laurent Cognet
    •  & Erwan Bezard
  • Article
    | Open Access

    The authors describe a huge submarine landslide deposit offshore Tanzania and highlight that large and potentially tsunamigenic landslide events are associated with plateau uplift and continental rifting in East Africa.

    • Vittorio Maselli
    • , David Iacopini
    • , Cynthia J. Ebinger
    • , Sugandha Tewari
    • , Henk de Haas
    • , Bridget S. Wade
    • , Paul N. Pearson
    • , Malcom Francis
    • , Arjan van Vliet
    • , Bill Richards
    •  & Dick Kroon
  • Article
    | Open Access

    Many Zintl ions with a single endohedrally encapsulated transition metal ion are known, but relatively few where clusters of two or more metals are present. Here, the authors report the synthesis and characterization of two clusters, [Au8Pb33]6− and [Au12Pb44]12−, which contain Au8 and Au12 cores surrounded by Pb shells.

    • Cong-Cong Shu
    • , Harry W. T. Morgan
    • , Lei Qiao
    • , John E. McGrady
    •  & Zhong-Ming Sun
  • Article
    | Open Access

    Bipolar conductivity is fundamental for electronic devices based on two-dimensional semiconductors. Here, the authors report on-demand p- and n-doping of monolayer MoS2 via defects engineering using thermochemical scanning probe lithography, and achieve a p-n junction with rectification ratio over 104.

    • Xiaorui Zheng
    • , Annalisa Calò
    • , Tengfei Cao
    • , Xiangyu Liu
    • , Zhujun Huang
    • , Paul Masih Das
    • , Marija Drndic
    • , Edoardo Albisetti
    • , Francesco Lavini
    • , Tai-De Li
    • , Vishal Narang
    • , William P. King
    • , John W. Harrold
    • , Michele Vittadello
    • , Carmela Aruta
    • , Davood Shahrjerdi
    •  & Elisa Riedo
  • Article
    | Open Access

    3D liver organoids hold great promise for regenerative medicine but the use of ill-defined matrices limits their potential. Here, the authors generate human and mouse liver organoids using a chemically defined matrix, and reveal a link between matrix stiffness and organoid growth that does not require acto-myosin contraction.

    • Giovanni Sorrentino
    • , Saba Rezakhani
    • , Ece Yildiz
    • , Sandro Nuciforo
    • , Markus H. Heim
    • , Matthias P. Lutolf
    •  & Kristina Schoonjans
  • Article
    | Open Access

    Neural plasticity underlies learning and is regulated by modulation of gap junctions. Here, the authors show that NMDAR- and CaMKII-mediated cell autonomous downregulation of gap junction molecules in a circuit of interneurons facilitates olfactory learning affecting behavior in C. elegans.

    • Myung-Kyu Choi
    • , He Liu
    • , Taihong Wu
    • , Wenxing Yang
    •  & Yun Zhang
  • Article
    | Open Access

    Here, the authors engineer an attenuated knock-out Leishmania (LmCen−/−) vaccine that is safe in immunocompromised mice and induces an immune response and protection similar to leishmanization with wild-type Leishmania. Since LmCen−/− is antibiotic resistant marker free, it is a candidate for clinical development.

    • Wen-Wei Zhang
    • , Subir Karmakar
    • , Sreenivas Gannavaram
    • , Ranadhir Dey
    • , Patrick Lypaczewski
    • , Nevien Ismail
    • , Abid Siddiqui
    • , Vahan Simonyan
    • , Fabiano Oliveira
    • , Iliano V. Coutinho-Abreu
    • , Thiago DeSouza-Vieira
    • , Claudio Meneses
    • , James Oristian
    • , Tiago D. Serafim
    • , Abu Musa
    • , Risa Nakamura
    • , Noushin Saljoughian
    • , Greta Volpedo
    • , Monika Satoskar
    • , Sanika Satoskar
    • , Pradeep K. Dagur
    • , J. Philip McCoy
    • , Shaden Kamhawi
    • , Jesus G. Valenzuela
    • , Shinjiro Hamano
    • , Abhay R. Satoskar
    • , Greg Matlashewski
    •  & Hira L. Nakhasi
  • Article
    | Open Access

    The presence of strong inter-layer interactions has hindered the synthesis efforts towards large-area and highly crystalline monolayer SnS. Here, the authors report synthesis of large-area monolayer SnS using a liquid metal-based technique, and fabricate piezoelectric nano-generators with average peak output voltage of 150 mV at 0.7% strain.

    • Hareem Khan
    • , Nasir Mahmood
    • , Ali Zavabeti
    • , Aaron Elbourne
    • , Md. Ataur Rahman
    • , Bao Yue Zhang
    • , Vaishnavi Krishnamurthi
    • , Paul Atkin
    • , Mohammad B. Ghasemian
    • , Jiong Yang
    • , Guolin Zheng
    • , Anil R. Ravindran
    • , Sumeet Walia
    • , Lan Wang
    • , Salvy P. Russo
    • , Torben Daeneke
    • , Yongxiang Li
    •  & Kourosh Kalantar-Zadeh
  • Article
    | Open Access

    Altered monocyte responses and testosterone levels correlate, individually, with the pathogenesis of hepatic amebiasis in mice. Here the authors show that testosterone induces enhanced TNF/CXCL1 expression and stronger proinflammatory responses in both human and mouse monocytes to support an androgen-monocyte axis of inflammation regulation.

    • Julie Sellau
    • , Marie Groneberg
    • , Helena Fehling
    • , Thorsten Thye
    • , Stefan Hoenow
    • , Claudia Marggraff
    • , Marie Weskamm
    • , Charlotte Hansen
    • , Stephanie Stanelle-Bertram
    • , Svenja Kuehl
    • , Jill Noll
    • , Vincent Wolf
    • , Nahla Galal Metwally
    • , Sven Hendrik Hagen
    • , Christoph Dorn
    • , Julia Wernecke
    • , Harald Ittrich
    • , Egbert Tannich
    • , Thomas Jacobs
    • , Iris Bruchhaus
    • , Marcus Altfeld
    •  & Hannelore Lotter
  • Article
    | Open Access

    Little is known about gene expression of organisms in the deep sea, partially owing to constraints on sampling these organisms in situ. Here the authors circumvent this problem, fixing tissue of a deep-sea mussel at 1,688 m in depth, and later analyzing transcriptomes to reveal gene expression patterns showing tidal oscillations.

    • Audrey M. Mat
    • , Jozée Sarrazin
    • , Gabriel V. Markov
    • , Vincent Apremont
    • , Christine Dubreuil
    • , Camille Eché
    • , Caroline Fabioux
    • , Christophe Klopp
    • , Pierre-Marie Sarradin
    • , Arnaud Tanguy
    • , Arnaud Huvet
    •  & Marjolaine Matabos
  • Article
    | Open Access

    In value-based decision-making, single prefrontal neurons represent multiple variables at different times in the decision process. Here, the authors show these representations to be separable and stable at the population level, allowing read out of specific variables at behaviorally relevant times.

    • Daniel L. Kimmel
    • , Gamaleldin F. Elsayed
    • , John P. Cunningham
    •  & William T. Newsome
  • Article
    | Open Access

    When our expectations are violated, it is adaptive to update our internal models to improve predictions in the future. Here, the authors show that during mnemonic violations, hippocampal networks are biased towards an encoding state and away from a retrieval state to potentially update these predictions.

    • Oded Bein
    • , Katherine Duncan
    •  & Lila Davachi
  • Article
    | Open Access

    Genetically encoded voltage indicators (GEVIs) allow visualisation of fast action potentials in neurons but most are bright at rest and dimmer during an action potential. Here, the authors engineer electrochromic FRET GEVIs with fast, bright and positive-going fluorescence signals for in vivo imaging.

    • Ahmed S. Abdelfattah
    • , Rosario Valenti
    • , Jihong Zheng
    • , Allan Wong
    • , Amy S. Chuong
    • , Jeremy P. Hasseman
    • , Vivek Jayaraman
    • , Ilya Kolb
    • , Wyatt Korff
    • , Luke D. Lavis
    • , Yajie Liang
    • , Loren L. Looger
    • , Derek Merryweather
    • , Daniel Reep
    • , Nelson Spruston
    • , Karel Svoboda
    • , Arthur Tsang
    • , Getahun Tsegaye
    • , Glenn Turner
    • , Kaspar Podgorski
    • , Minoru Koyama
    • , Douglas S. Kim
    •  & Eric R. Schreiter
  • Article
    | Open Access

    Ribozyme-based RNase MRP is an essential eukaryotic enzyme involved in the maturation of rRNA and is evolutionarily related to RNase P. Here, the authors present the 3.0 Å cryo-EM structure of the S. cerevisiae RNase MRP holoenzyme, a 450 kDa ribonucleoprotein complex and compare it with RNase P.

    • Anna Perederina
    • , Di Li
    • , Hyunwook Lee
    • , Carol Bator
    • , Igor Berezin
    • , Susan L. Hafenstein
    •  & Andrey S. Krasilnikov
  • Article
    | Open Access

    Streptococcus pneumoniae is an opportunistic pathogen and asymptomatic colonization is a precursor for invasive disease. Here the authors show rapid within-host evolution of naturally acquired pneumococci in ninety-eight infants driven by high nucleotide substitution rates and intra-host homologous recombination.

    • Chrispin Chaguza
    • , Madikay Senghore
    • , Ebrima Bojang
    • , Rebecca A. Gladstone
    • , Stephanie W. Lo
    • , Peggy-Estelle Tientcheu
    • , Rowan E. Bancroft
    • , Archibald Worwui
    • , Ebenezer Foster-Nyarko
    • , Fatima Ceesay
    • , Catherine Okoi
    • , Lesley McGee
    • , Keith P. Klugman
    • , Robert F. Breiman
    • , Michael R. Barer
    • , Richard A. Adegbola
    • , Martin Antonio
    • , Stephen D. Bentley
    •  & Brenda A. Kwambana-Adams
  • Article
    | Open Access

    There is a growing interest in performing time-resolved cryo-EM studies. Here, the authors present a time-resolved sample preparation method for cryo-EM called trEM, which uses a microfluidic device to initiate the biochemical reaction by rapid mixing of the components and then spraying the sample onto a cryo-EM grid to snap-freeze it in a blot-free, automated manner within several milliseconds.

    • Märt-Erik Mäeots
    • , Byungjin Lee
    • , Andrea Nans
    • , Seung-Geun Jeong
    • , Mohammad M. N. Esfahani
    • , Shan Ding
    • , Daniel J. Smith
    • , Chang-Soo Lee
    • , Sung Sik Lee
    • , Matthias Peter
    •  & Radoslav I. Enchev
  • Article
    | Open Access

    The authors of this study compile data on spatial and temporal dynamics of surface water bodies across China, covering a time span from 1989 – 2016. The study describes hot-spot areas with strongly decreasing trends in surface water area and terrestrial water storage in North China and discusses implications of water resources and security in China.

    • Xinxin Wang
    • , Xiangming Xiao
    • , Zhenhua Zou
    • , Jinwei Dong
    • , Yuanwei Qin
    • , Russell B. Doughty
    • , Michael A. Menarguez
    • , Bangqian Chen
    • , Junbang Wang
    • , Hui Ye
    • , Jun Ma
    • , Qiaoyan Zhong
    • , Bin Zhao
    •  & Bo Li
  • Article
    | Open Access

    Studies on examining the climate impact on irrigated agriculture do not account for regional specific details. Here the authors studied both the direct and indirect impact of climate change on irrigated agriculture in the Yakima River Basin (YRB) and found that increasingly severe droughts and temperature driven reductions in growing season significantly reduces expected annual agricultural productivity.

    • Keyvan Malek
    • , Patrick Reed
    • , Jennifer Adam
    • , Tina Karimi
    •  & Michael Brady
  • Article
    | Open Access

    Most current cell sorting methods are based on fluorescence detection with no imaging capability. Here the authors generate and use Raman image-activated cell sorting with a throughput of around 100 events per second, providing molecular images with no need for labeling.

    • Nao Nitta
    • , Takanori Iino
    • , Akihiro Isozaki
    • , Mai Yamagishi
    • , Yasutaka Kitahama
    • , Shinya Sakuma
    • , Yuta Suzuki
    • , Hiroshi Tezuka
    • , Minoru Oikawa
    • , Fumihito Arai
    • , Takuya Asai
    • , Dinghuan Deng
    • , Hideya Fukuzawa
    • , Misa Hase
    • , Tomohisa Hasunuma
    • , Takeshi Hayakawa
    • , Kei Hiraki
    • , Kotaro Hiramatsu
    • , Yu Hoshino
    • , Mary Inaba
    • , Yuki Inoue
    • , Takuro Ito
    • , Masataka Kajikawa
    • , Hiroshi Karakawa
    • , Yusuke Kasai
    • , Yuichi Kato
    • , Hirofumi Kobayashi
    • , Cheng Lei
    • , Satoshi Matsusaka
    • , Hideharu Mikami
    • , Atsuhiro Nakagawa
    • , Keiji Numata
    • , Tadataka Ota
    • , Takeichiro Sekiya
    • , Kiyotaka Shiba
    • , Yoshitaka Shirasaki
    • , Nobutake Suzuki
    • , Shunji Tanaka
    • , Shunnosuke Ueno
    • , Hiroshi Watarai
    • , Takashi Yamano
    • , Masayuki Yazawa
    • , Yusuke Yonamine
    • , Dino Di Carlo
    • , Yoichiroh Hosokawa
    • , Sotaro Uemura
    • , Takeaki Sugimura
    • , Yasuyuki Ozeki
    •  & Keisuke Goda
  • Article
    | Open Access

    Insertions/Deletions (InDels) remain an untapped source of protein diversity in laboratory evolution. The method TRIAD generates libraries of random variants with short in-frame InDels using transposons, allowing a comparison of their evolutionary potential with widely-used point mutant libraries.

    • Stephane Emond
    • , Maya Petek
    • , Emily J. Kay
    • , Brennen Heames
    • , Sean R. A. Devenish
    • , Nobuhiko Tokuriki
    •  & Florian Hollfelder
  • Article
    | Open Access

    Band topology of Weyl semimetals is usually predetermined by material parameters and can hardly be manipulated, and their transport properties appear at low temperature. Here, the authors modify the topology via a weak magnetic field and observe a giant anomalous Hall effect at room temperature.

    • Peigang Li
    • , Jahyun Koo
    • , Wei Ning
    • , Jinguo Li
    • , Leixin Miao
    • , Lujin Min
    • , Yanglin Zhu
    • , Yu Wang
    • , Nasim Alem
    • , Chao-Xing Liu
    • , Zhiqiang Mao
    •  & Binghai Yan
  • Article
    | Open Access

    Though wearable electronics remain an attractive technology for bioelectronics, fabrication methods that precisely print biocompatible materials for electronics are needed. Here, the authors report an additive manufacturing process that yields all-printed nanomaterial-based wireless electronics.

    • Young-Tae Kwon
    • , Yun-Soung Kim
    • , Shinjae Kwon
    • , Musa Mahmood
    • , Hyo-Ryoung Lim
    • , Si-Woo Park
    • , Sung-Oong Kang
    • , Jeongmoon J. Choi
    • , Robert Herbert
    • , Young C. Jang
    • , Yong-Ho Choa
    •  & Woon-Hong Yeo
  • Article
    | Open Access

    Glutaredoxins are a family of essential enzymes divided into two major classes with either a CGFS or a CxxC active site, of which only the latter exhibits oxidoreductase activity. Here the authors address the structural basis for the functional difference between the two classes of glutaredoxins.

    • Daniel Trnka
    • , Anna D. Engelke
    • , Manuela Gellert
    • , Anna Moseler
    • , Md Faruq Hossain
    • , Tobias T. Lindenberg
    • , Luca Pedroletti
    • , Benjamin Odermatt
    • , João V. de Souza
    • , Agnieszka K. Bronowska
    • , Tobias P. Dick
    • , Uli Mühlenhoff
    • , Andreas J. Meyer
    • , Carsten Berndt
    •  & Christopher Horst Lillig
  • Article
    | Open Access

    It is not entirely understood how network plasticity produces the coding of predicted value during stimulus-outcome learning. Here, the authors reveal a reinforcing loop in distributed limbic circuits, transforming sensory stimuli into reward prediction coding broadcasted by dopamine neurons to the brain.

    • Lars-Lennart Oettl
    • , Max Scheller
    • , Carla Filosa
    • , Sebastian Wieland
    • , Franziska Haag
    • , Cathrin Loeb
    • , Daniel Durstewitz
    • , Roman Shusterman
    • , Eleonora Russo
    •  & Wolfgang Kelsch
  • Article
    | Open Access

    Here, the authors develop a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle as a vaccine candidate and show induction of neutralization antibody titers in mice that are comparable to titers in convalescent sera of patients.

    • Paul F. McKay
    • , Kai Hu
    • , Anna K. Blakney
    • , Karnyart Samnuan
    • , Jonathan C. Brown
    • , Rebecca Penn
    • , Jie Zhou
    • , Clément R. Bouton
    • , Paul Rogers
    • , Krunal Polra
    • , Paulo J. C. Lin
    • , Christopher Barbosa
    • , Ying K. Tam
    • , Wendy S. Barclay
    •  & Robin J. Shattock
  • Article
    | Open Access

    Better understanding the synergy between radiation and corrosion is necessary to deploy advanced nuclear reactors. Here, the authors contradict the misconception that radiation always results in deleterious effects and show that proton irradiation slows the corrosion of Ni-Cr alloys in 650 °C molten salt.

    • Weiyue Zhou
    • , Yang Yang
    • , Guiqiu Zheng
    • , Kevin B. Woller
    • , Peter W. Stahle
    • , Andrew M. Minor
    •  & Michael P. Short