Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
In patient with glioblastoma, a major cause of resistance to chemotherapy and radiotherapy is the high degree to intratumoral heterogeneity and cell plasticity. Here, the authors demonstrate that chemoradiation induces the reprograming of glioblastoma cells into an invasive and vessel co-opting state, termed VC-Resist, capable of promoting resistance to therapy.
The design of synthetic systems that can sense chemical gradients and respond with directional motility and chemical activity is of interest. Here, the authors realize and control such behaviors in a synthetic system by tailoring multivalent interactions of adenosine nucleotides with catalytic microbeads.
The regulation of meiotic prophase progression varies between males and females. This study reveals the involvement of an atypical heat shock transcription factor HSF5 in gene expression during male meiotic prophase and highlights the involved gene regulatory mechanism.
Salt marsh planting strategies aim to reduce coastal degradation. Here, the authors conduct a global meta-analysis showing that planting enhances coastal wetland ecosystem services although not to the level of natural wetlands.
Triazole antifungals are widely used and exert their action by inhibiting ergosterol biosynthesis. Here, Rybak et al show that these drugs both inhibit ergosterol biosynthesis and induce accumulation of pathway intermediates that directly induce inhibition of sterol synthesis.
Here, the authors report the ledge-guided epitaxial growth of high-density 2D Bi2O2Se fin arrays and their application for the realization of 2D multi-channel fin field-effect transistors, showing improved on-state currents as the number of integrated channels is increased.
Invasive populations often have low genetic diversity because they originated from a small number of founding individuals. This study shows that in an invasive honey bee, one consequence of low genetic diversity is a reduced rate of population expansion due to serial founder effects at range edges.
Rhizaria are abundant protists in the ocean and likely important to biogeochemical cycling. In this study the authors assess the global distribution, biomass and biogeochemical significance of Rhizaria, finding that they play an important role in carbon flux attenuation and dominate silicon cycling in the mesopelagic zone.
Researchers report a sustainable nanofluidic osmotic energy harvester made from natural montmorillonite clay nanosheets and recycled cellulose. Scaled-up films of 700 cm2 show power output of 8 W m−2 with stability over 30 days
The stability of non-noble catalysts is key for their use in proton exchange membrane water electrolysers. Here, authors study activity-stability relationships of MoSx allotropes for H2 production, reporting allotrope-dependent stabilities and dissolution pathways, and propose operation guidelines.
The avalanche or carrier-multiplication effect has the potential to improve the performance of photodetectors and solar cells, but usually requires high threshold energies. Here, the authors report stepwise WSe2 homojunctions exhibiting threshold energies approaching the semiconductor bandgap at room temperature.
Here, the authors present a multi-omics examination of stool samples obtained from individuals with diverticulitis and controls, uncovering disruptions in the balance of microbial composition and metabolites, as well as co-occurring microbe-metabolite associations relevant to the disease.
Influenza B viruses are linked to significant morbidity and mortality, and yet their immunobiology is comparatively poorly understood. Here Menon et al identify influenza B virus-specific CD8+ T cell epitopes and characterise these in adults, children and the elderly.
Electron holography discovered nonmagnetic framboids and many iron nanoparticles with a vortex magnetic flux formed by magnetite reduction due to a micrometeoroid impact on asteroid Ryugu, providing a new way to study the Solar System magnetic field.
In this study, the authors report the case of a patient who underwent lung transplantation and subsequently developed COVID-19 that resulted in persistent infection. Following antiviral treatment, SARS-CoV-2 (BA.5) showed dynamic genetic diversity with remdesivir resistant mutations leading to enhanced fusogenicity.
2D MOFs have a variety of applications, including molecular separation and atomically thin electronics. Here authors demonstrate the preparation of monolayer and few-layer MOF single-crystals using a self-condensation-assisted CVD method.
An adequate immune response is necessary to promote heart regeneration. Here, the authors identified a link between antigen presentation, immune cells, and endocardial cells during the regenerative response to cardiac injury in the adult zebrafish.
Compared to well-developed catalytic 1,2-diazidation of alkenes, the corresponding catalytic 1,1-diazidation of alkenes has not been realized. Here, the authors report an efficient approach for catalytic 1,1-diazidation of alkenes by redox-active selenium catalysis.
A mitochondrion-localised BAHD acyltransferase (3β-tigloyloxytropane synthase, TS) from Atropa belladonna is responsible for the formation of 3β-tigloyloxytropane, the key intermediate in calystegine biosynthesis.