Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Traction force microscopy is an effective method for measuring cellular forces but it is limited by planar geometry. Here the authors develop a facile method to produce deformable hydrogel particles and a reference-free computational method to resolve surface traction forces from particle shape deformation.
Multivariable Mendelian randomization (MR) extends the standard MR framework to consider multiple risk factors in a single model. Here, Zuber et al. propose MR-BMA, a Bayesian variable selection approach to identify the likely causal determinants of a disease from many candidate risk factors as for example high-throughput data sets.
The authors show that a subanesthetic dose of ketamine markedly elevate calcium signals in apical dendritic spines in the mouse prefrontal cortex. This effect is driven by a local-circuit mechanism that involves the suppression of somatostatin interneurons leading to dendritic disinhibition.
To better understand the response of Earth’s crust to earthquakes, it is valuable to mimic the geographic scale phenomena in laboratory scale experiment. Here, Bera et al. show that large bursts in ground acceleration of real earthquakes can be well reproduced in two soft, yield stress materials.
Horizontal gene transfer (HGT) in complex bacterial communities has been mostly studied using metagenomic analyses. Here, the authors develop an E. coli CRISPR-Cas spacer acquisition platform that allows real-time recording of HGT events at nucleotide-resolution, identifying diverse DNA transfer events in human clinical fecal samples.
Glass transition in soft materials can be affected by the topology of constituent particles, but the detail remains elusive. Here, Smrek et al. show that the interplay between circular topology of ring polymers and their active segments generates a new state of matter, namely active topological glass.
The authors here investigate in the 2019 Ridgecrest earthquakes in Searles Valley, California. Based on geodetic and seismological data, the authors separate the event into two earthquakes (Mw 6.5 and 7.1) and produce kinematic slip models of the event.
Highly efficient catalysts are demanded to realize selective hydrogenation of ketone/aldehydes to alcohols under mild conditions. Here, the authors report a TiO2 supported Pd single-atom/nanoparticles synergistic catalyst with outstanding hydrogenation performance at room temperature.
BCL9 is an activator of oncogenic Wnt/β-catenin. Here, the authors show a β-catenin independent function of BCL9 in a subtype of colorectal cancers, where it interacts with paraspeckle proteins to enhance the mRNA stability of calcium signalling and neural associated genes to promote communication with tumour cells and its microenvironment.
Emergent quantum phenomena such as quantized anomalous Hall effect may be realized in magnetic topological materials. Here, Hu et al. discovered an intrinsic natural heterostructural Z2 antiferromagnetic topological insulator MnBi4Te7 with low out-of-plane saturation fields.
U1 snRNP is a key regulator of mRNA biogenesis through its roles in splicing, and transcription and 3’-end processing. Here the authors show a tumor suppressor-like function of U1 snRNP using in vitro cell migration/invasion assays and transcriptome profiling.
TGF-β is thought to be important for group 2 innate lymphoid cell (ILC2) function. Here the authors show that TGF-β drives expression of ST2 specifically in ILC2 progenitors and thereby is also important for the development of ILC2s in the bone marrow.
Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy subjects, and show that osteoclast-derived DPP4 may be a factor coupling bone resorption to energy metabolism.
Olivine crystals with prominent intracrystalline distortions have previously been used to quantify deformational processes within the mantle. Here, the authors show that similar techniques can be applied to deformed volcanic olivine crystals, providing quantitative constraints on the geometry of melt-rich mush piles within magmatic plumbing systems.
Here, using high spatiotemporal resolution light-sheet and fluorescence microscopy, the authors investigate the role of cytoskeletal components on the intracellular transport of Rab11A and influenza virus (IAV) vRNP), and show a preference for Rab11A movement along microtubules that is not essential for IAV vRNP transport.
Here, the authors develop a reverse epitaxial process whereby a nanocrystalline Au film becomes highly textured and support a suspended 2D WSe2 overlayer. Surface plasmon polaritons are launched in nanostructured Au by laser excitation and couple remotely to single photon emitters present in WSe2.
The ubiquitin ligase Siah2 has been implicated in immune responses. Here, the authors show that Siah2 null immune cells have an increased inflammatory response to inoculated melanoma cells, along with a reduced number of infiltrating immunosuppressive regulatory T cells, resulting in inhibition of tumour growth.
Wind changes the surface of the Earth, but the surface characteristics of the planet also impact the winds above it. Here, the authors propose a feedback process in which wind erosion in the western Gobi Desert alters the thermal properties of the surface, which in turn increases near-surface winds.
Constituitively active CRISPR systems have the risk of adverse off-target effects. Here the authors use chemical masking and activation of gRNA to control activity.