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Future zero-energy buildings require smart and dynamic utilization of renewable energy for efficient indoor temperature control. Here the authors show that the dual-mode device enables building envelopes to switch between solar heating and radiative cooling to save HVAC energy for all seasons and all climate zones.
Single-cell transcriptomics enhanced our ability to profile heterogeneous cell populations. It is not known which statistical frameworks are performant to detect subpopulation-level responses. Here, the authors developed a simulation framework to evaluate various methods across a range of scenarios.
Chiuppesi et al. demonstrate the use of a synthetic poxvirus-based platform to rapidly generate multi-antigenic vaccine candidates expressing spike and nucleocapsid antigens of SARS-CoV-2. Immunization of mice stimulates potent antigen-specific humoral and cellular immune responses, including neutralizing antibodies.
How clamp conformation is regulated in the transcription cycle of stalk-containing archaeal and eukaryotic RNA polymerase (RNAP) systems is still not well understood. Here, the authors combine cryo-EM, X-ray crystallography and photo-crosslinking assays to structurally characterise RNAP, the RNAP-TFEα binary and RNAP-TFEα-promoter DNA ternary complexes from the archaea Thermococcus kodakarensis and enables them to describe the dynamic conformational changes of the general transcription factor TFEα and RNAP during the early stage of transcription cycle.
Accurately measuring genetic relatedness by Identical-By-Descent (IBD) segments is challenging in biobank-level genome data. The authors present IBD method FastSMC, which when applied to the UK Biobank gives a detailed picture of genetic relatedness and evolutionary history in the UK over the past 2000 years.
Developing a generalizable model to describe adsorption processes at metal surfaces can be extremely challenging due to complex phenomena involved. Here the authors introduce a Bayesian learning approach based on ab initio data and the d-band model to capture the essential physics of adsorbate–substrate interactions.
Bacterial and fungal pathogens that cross the blood-brain-barrier (BBB) can cause severe disease. Here, Benmimoun et al. develop a model to study BBB crossing in the developing Drosophila brain and discover Group B Streptococcus factors important for BBB crossing and virulence, one of which, a lipoprotein, they confirm in mice.
Transition-metal atoms deposited on metal surfaces exhibit zero bias anomalies, which have been detected by scanning tunnelling spectroscopy and are commonly attributed to Kondo resonances. Here the authors explain the zero-bias anomalies in terms of gapped spin-excitations in contrast to Kondo resonances, which reproduce well the experiments.
The possibility to manipulate the propagation of polaritons is limited by the isotropy of 2D materials like graphene and hexagonal boron nitride. Here, the authors exploit the anisotropy of α-MoO3 and study edge tailored hyperbolic polariton manipulation in α-MoO3 nanocavities via real space nanoimaging.
Existing neural interfaces are limited in accessing one, small brain region. Here, the authors introduce a scaffold with helix hollow channels, which direct multisite multifunctional fibre probes into the brain at different angles, allowing for simultaneous recording and stimulation across distant regions.
Altered fatty acid intake during pregnancy is associated with neurodevelopmental disorders. Here, the authors show that maternal omega-3 fatty acids deficiency results in altered microglia-mediated phagocytosis of synaptic elements leading to impaired cognitive functions in the offspring in mice.
Photosynthetic formation of manganese (Mn) oxides from dissolved Mn ions was proposed to occur in ancestral photosystems before oxygenic photosynthesis evolved. Here, the authors provide evidence for this hypothesis by showing that photosystem II devoid of the Mn cluster oxidises Mn ions leading to formation of Mn-oxide nanoparticles.
Neoadjuvant FLOT regimen has shown promising results for the treatment of locally advanced gastric cancer, however SOX regimen remains the preferred chemotherapy in Eastern countries. Here the authors report that the two therapies result in similar outcomes, measured as clinical downstaging and pathological response, in a phase II randomized clinical trial.
The role of mTORC1 at the lysosome is well established, but mTORC1 is known to be active in other cellular locations. Here, the authors develop Akt-STOPS to inhibit Akt specifically in the nucleus and identify a new regulatory mode for mTORC1 distinct in the nucleus.
Interpretation of Computed Tomography Angiography for intracranial aneurysm diagnosis can be time-consuming and challenging. Here, the authors present a deep-learning-based framework achieving improved performance compared to that of radiologists and expert neurosurgeons.
The high bond energies of C–O bonds in biomass and its derivatives make their cleavage very challenging. Here, the authors report a photoredox-catalyzed C–O bond cleavage in diaryl ethers by acidolysis with an aryl carboxylic acid followed by hydrolysis in a one-pot manner.
Imbalance of microglial phenotypes in the aging brain might underlie their involvement in late onset neurodegenerative diseases. Here we report the population structure of microglia in the aged human brain and the reduction of a particular microglia subset in individuals with Alzheimer’s disease .
Adenocarcinoma at the gastroesophageal junction has a dismal prognosis and few drug options. Here, the authors present genomic and transcriptomic features and potential therapeutic targets and prognostic biomarkers of Chinese and Caucasian tumours, and reveal the molecular similarities.
Previous studies have identified DNA methylation changes in Alzheimer’s disease. Here the authors perform a meta-analysis of DNA methylation datasets to identify epigenetic correlates of Alzheimer’s disease in the prefrontal cortex.
Perceptually unidentifiable stimuli are encoded in the visual cortex, such as to facilitate their future processing in a task context. This form of priming may constitute a pre-attention mechanism using the mere frequency of stimulus occurrence to change stimulus representations, even when sensory inputs are perceptually invisible.