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Manipulation of paramagnetic microparticles can be exploited for drug delivery. Here the authors manipulate a swarm of such particles and control its shape with a magnetic field so that it can elongate reversibly, split into smaller swarms and thus be guided through a maze with multiple parallel channels.
Oligodendrocyte progenitor cells (OPCs) undergo asymmetric cell division, and disruption of such mechanism can generate oligodendroglioma precursors. Here, Daynac and colleagues show that Lgl1 regulates asymmetric division and differentiation of OPCs by interfering with the endocytosis pathway, and that Lgl1 knockout can lead to gliomagenesis.
The fossil taxon Propotto was originally identified as a primate, but is currently widely interpreted as a bat. Here, the authors identify Propotto as a stem chiromyiform lemur and, based on phylogenetic analysis, suggest two independent lemur colonizations of Madagascar.
Dynamin-like proteins (DLPs) such as the mitofusins form homotypic and heterotypic oligomers that bridge and fuse opposing membranes. Here, Liu, Noel and Low present the crystal structure of a bacterial DLP heterotypic pair, providing insights into the mechanism behind long-range binding of opposing membranes.
Ceramides are signalling molecules that regulate several physiological functions including insulin sensitivity. Here the authors report a selective ceramide synthase 1 inhibitor that counteracts lipid accumulation within the muscle and adiposity by increasing fatty acid oxidation but without affecting insulin sensitivity in mice fed with an obesogenic diet.
Although it is well known that silica can dissolve in water, the precise mechanism is unclear. Here, the authors employ sum frequency generation spectroscopy to probe the interfacial water structure reporting directly on the underlying dissolution mechanism, which appears to be auto-catalytic.
The Late Chalcolithic material culture in the southern Levant has unique attributes that suggest spread of people or culture. Here, the authors use genome-wide ancient DNA data from 22 individuals from a Chalcolithic site and show evidence of complex population movements and turnovers.
Large mechanocaloric effects are disclosed in lithium-ion superionic conductors at room temperature. These occur in the absence of any structural phase transition, which is beneficial from a practical point of view, and are related to stress-induced variations in the ionic conductivity.
Hypoxic tumors are resistant to dynamic therapy, limiting potential treatment options. Here, the authors describe a nanoflower where oxidase mimicking PtCo nanoparticles are decorated with catalase mimicking MnO2 to reverse tumor hypoxia and generate reactive oxygen species for dynamic therapy.
How intrinsically disordered proteins (IDPs) undergo a coupled folding and binding reaction with their molecular targets remains to be understood. Here authors use single-molecule FRET to assess the contribution of cis/trans isomerization of peptidyl-prolyl bonds in regulating IDP interactions.
Here, the authors perform spectroscopic investigations of individual Formamidinium lead iodide nanocrystals, demonstrate single-photon emission and unravel the mechanisms of carrier–phonon interactions. These results will guide the development of next-generation devices for photovoltaics and quantum technologies.
SFTSV is a novel phlebovirus associated with high fatality, but understanding of pathogenesis is lacking. Here the authors show defective cellular immunity, deficient antibody production and defunct humoral immunity is associated with fatal infection in human cases of infection.
Plasmacytoid dendritic cells (pDC) are a pivotal component of the immune system. Here, the authors utilize single-cell microfluidics to interrogate the human pDC compartment and reveal a subset of type I IFN secreting pDCs that is regulated by stochastic gene expression and amplified by microenvironmental cues.
In general the computational requirements for simulating quantum systems scale exponentially but in some cases it is possible to formulate more efficient schemes. Here the authors present an efficient approach to calculate non-Markovian quantum dynamics using matrix product operator methods.
Digital traces of our lives have the potential to allow insights into collective behaviors. Here, the authors cluster consumers by their credit card purchase sequences and discover five distinct groups, within which individuals also share similar mobility and demographic attributes.
De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with divergent DNA methylation associated with private LITs.
High temperature perpendicular ferroelectricity in nano thin films is crucial for miniaturization of electronic devices. Here the authors show the presence of stable and switchable out-of-plane ferroelectricity in tetragonal BiFeO3 thin films at the two-dimensional limit and 370% tunneling electroresistance in ferroelectric tunnel junctions.
The competition between Kondo correlations and magnetic ordering in heavy fermion materials leads to emergent physics that is not fully understood. Seiro et al. show inter-site Kondo correlations only dominate over local ones at temperatures well below the single-ion Kondo temperature but this is a prerequisite for quantum critical behavior.
Mucormycosis is a life-threatening respiratory fungal infection that typically occurs in patients with abnormalities in iron metabolism. Here the authors show that iron restriction inside the phagosome of macrophages is an essential component of the host defense against Rhizopus, the main species causing mucormycosis.
Heat transport in ultrathin metal layers is important for potential applications in optical‐magnetic switching, but difficult to access experimentally. Here, the authors use ultrafast X‐ray diffraction to directly probe and explain unexpected time‐dependent transport behavior in Au–Ni nanolayers.