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Somatic cloning of rhesus monkey has not been successful until now. Here, authors report epigenetic abnormalities in SCNT embryos and placentas and develop a trophoblast replacement method that enables them to successful clone of a healthy male rhesus monkey.
Thermoelectric power factor in multiple two-dimensional electron gas in GaAs is enhanced by the effect of multiple subbands. The enhancement rate is 4 times larger than that of conventional two-dimensional electron gas system.
Deformation twinning in body-centered cubic (BCC) metals is generally believed to be controlled by twin nucleation, but facilitated by rapid twin growth once the nucleation energy barrier is overcome. Here, the authors demonstrate both nucleation- and growth-controlled twinning modes in BCC Ta nanocrystals depending on the crystal size.
The mechanism of amorphous-amorphous transitions is highly debated. Here, the authors use molecular dynamics simulations to reveal transitions via nucleation-growth or spinodal decomposition, resembling a thermodynamic phase transition but influenced by mechanics.
What a microbial strain is and how many strains make up a natural bacterial population remain elusive concepts. Here, Viver et al. analyse Salinibacter ruber isolates and metagenomes from two solar salterns, revealing gaps within the species sequence space that they use to define and quantify sub-species categories, such as genomovars and strains, that co-exist in a saltern pond.
Lower respiratory tract disease is a common complication after allogeneic hematopoietic cell transplant (HCT), but underlying reasons remain unclear. Here the authors show that HHV-6B detection in the lungs of allogeneic HCT recipients is associated with increased risk for death and distinct host gene expression profiles, implicating HHV-6B as a pulmonary pathogen in these patients.
3D higher-order topological insulators (HOTIs) exhibit 1D hinge states depending on extrinsic sample details, while intrinsic features of HOTIs remain unknown. Here, K.S. Lin et al. introduce the framework of spin-resolved topology to show that helical HOTIs can realize a doubled axion insulator phase with nontrivial partial axion angles.
In this work, the authors report the FreeDTS software to simulate biomembranes at the mesoscale. The software provides various membrane simulations, focusing on protein organization and shape remodeling. A versatile tool propelling realistic membrane studies and diverse applications.
Direct and site-selective C–H functionalization of alkenes under environmentally benign conditions represents a useful and attractive yet challenging transformation to access value-added molecules. Here, the authors report a protocol for a variety of intermolecular Heck-type functionalization of C(sp2)–H bond of alkenes by thianthrenation.
Inter-fullerene conjugates are non-naturally occurring carbon allotropes. Here the authors report on the chemical synthesis and solid-state structure of three inter-[60]fullerene hybrids with inherent chirality.
Clonal Vb2 usage is common among patients with mature T cell lymphoma. Here the authors report the generation of allogeneic CAR-T cells selectively targeting TCR Vb2+ on malignant T cells, with limited normal T cell destruction.
Carbon dioxide electroreduction in acidic environments has been suboptimal. Here, the authors addressed this issue by designing a gas diffusion electrode with a special metal structure, which achieves efficient electroreduction while conducting a systematic investigation of the underlying mechanism.
Genetic variants that influence gene expression play a major role in human phenotypic variability and disease susceptibility. Here, the authors introduce a computational method to estimate the regulatory effect size in genes with multiple conditionally independent regulatory variants.
The cues guiding hematopoietic stem cells (HSCs) to regenerate specific cell types lost due to injury remain elusive. This study shows that iron instructs erythroid differentiation of HSCs during anemia in a Tet2-dependent manner.
The authors report a family of photocatalysts containing Ce active sites and perylene diimide ligands for the aerobic oxidation of substituted toluene, ethylbenzene, benzyl alcohol, thioanisole, and benzylamine in acetonitrile.
In existing soft robotic sensing strategies, additional components and design changes are often required to sense the environment. Zou et al. introduce a retrofit self-sensing strategy for soft pneumatic actuators, utilizing internal pressure variations arising from interactions.
Transport of rodlike particles in macromolecular networks is relevant to various biological processes and technological applications, where thin rods have been mainly in focus. Here the authors investigate diffusion dynamics of thick rods in confinement media of macromolecular networks, and uncover dependence of translational diffusion upon rod length.
The T cell receptor signalosome integrates multiple positive and negative regulatory elements to finetune the response and limit harmful inflammation. Here authors show a regulatory cascade of T cell activation, in which DUSP22 negatively regulates UBR2, which is an activator of the kinase Lck via K63 ubiquitination.
Technologies in human emotion recognition are challenged by their capability to accurately extract and exploit the emotional information. Lee et al. report a personalized skin-integrated facial interface to sense and combine facial and vocal expression data, enabling enhanced communication in virtual reality.
The pathobiology of heart failure (HF) is incompletely understood. The authors identify 37 circulating proteins and 5 protein modules associated with HF risk, with several demonstrating causal effects on HF, risk factors, or cardiac dysfunction by Mendelian randomization analysis.