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Terpene cyclases enable the synthesis of (poly)cyclic carbon frameworks via ring closure of linear polyenes. Here, the authors report in-situ formed fluorinated-alcohol-amine supramolecular clusters that mimic terpene cyclases for shape-controlled polyene cyclizations.
Airway epithelial repair, a key process in the recovery from lung injury, requires a metabolic shift from glycolysis to fatty acid oxidation (FAO). Pharmacological FAO promotion enhances epithelial differentiation, suggesting new therapeutic options.
In this work the authors report a quasi two-dimensional population of living cells that can spontaneously self-assemble into finite-sized domains, an analogue of the microphase separation known in inert matter.
The role of therapy in shaping the tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) remains to be explored. Here, the authors perform single-cell RNA sequencing in PDAC samples before and after chemotherapy and suggest that chemotherapy may promote resistance to immunotherapy.
Boosting activity of oxide catalysts is a long-lasting challenge to developing efficient catalysts for industrially important reactions such as CO2-to-methanol. Here, the authors report a strategy for enhancing the activity of a ZnZrOx methanol synthesis catalyst via engineered nanoscale H supply.
Immunocompromised patients are vulnerable to respiratory viral infections. Here, the authors characterize cross-neutralizing antibodies to respiratory syncytial virus, human metapneumovirus, and human parainfluenza viruses and show effective protection in male hamsters.
The synthesis of functionalizable nanographenes remains challenging. Here, the authors report that mechanochemical Scholl reaction allows access to regioselectively modifiable curved nanographenes in a high-yielding and general manner.
Here the authors show efficacy of a low-dose, unmodified, bivalent mRNA vaccine against SARS-CoV-2 variants in two female rodent models and find that combination of mRNA encoding Beta and Delta Spike sequences induces broadly neutralizing antibodies and robust T-cell responses.
Reconfigurability and robustness are two key properties for electromagnetic devices. Here, the use of compliant mechanisms—which are known for their inherent durability, structural stability, and high-accuracy manipulation capabilities in mechanical applications—is introduced for reconfigurable electromagnetic systems.
Self-healing materials hold great promise for applications in wearable electronics, artificial muscles and soft robots but selfhealing at subzero temperatures remains a great challenge. Here, the authors present a robust subzero healable glassy polymer by incorporating polyphenol nano-assemblies with a large number of end groups into polymerizable deep eutectic solvent elastomers.
Manipulating molecular self-assembly and disassembly in vivo may permit temporal control of drug delivery and release. Here, the authors report a fluorogenic cisplatin prodrug for cancer theranostics by leveraging stimuli-triggered in situ self-assembly and intracellular disassembly processes.
Hydrogels are networked hydrophilic polymers with enriched polar groups and confined water but are relatively less explored as electrocatalysts. Here, the authors demonstrate that insulative polymeric hydrogels can be an underlying catalogue of metal-free oxygen evolution electrocatalyst with huge extension potentials.
DFT simulations may be inaccurate in modeling aqueous systems, with results depending on the choice of the exchange-correlation functional. Here, the authors present an integrative method called HF-r2SCAN-DC4 that provides near chemical accuracy in electronic structure information not only for pure water but also for molecules dissolved in it
Geochemical modeling shows that just a several percent expansion of O2-free areas with toxic sulfide build-up likely contributed to biodiversity loss or reorganization during the Toarcian mass extinction 183 million years ago.
Glycine receptors are channel receptors mediating signal transduction between neurons that transit between resting and open states upon neurotransmitter binding. Here, the authors illuminate a progressive transition of opening by combining voltage-clamp fluorometry and molecular dynamics.
Difficulty swallowing after stroke and the neural circuitry underlying this is not fully understood. Here the authors demonstrate, using a mouse model, a potential neural circuit mechanism for effects of electroacupuncture on swallowing behaviour in post-stroke dysphagia.
KMT2A rearranged infant acute lymphoblastic leukemia patients have a poor prognosis. Here, the authors use high throughput drug screening on primary infant specimens to identify a clinically active chemotherapy combination.
Ordered oxygen complexes (OOCs) endow a unique interstitial strengthening mechanism for simultaneously enhancing strength and ductility in HEAs. Here, the authors demonstrate whether such mechanism can be extended to other alloy systems and how the formation of OOCs is tailored.
Oligodendrocytes have been increasingly shown to be involved in Alzheimer’s disease (AD). Here, the authors perform single-cell RNA-sequencing on APP NL-G-F mice and describe a disease-associated oligodendrocyte (DAO) population. They find inhibition of Erk1/2 signaling in DAOs rescues impaired axonal myelination and cognitive decline in an AD mouse model.