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Here, using cryo-electron microscopy and solution NMR, the authors reveal the structural and dynamic mechanisms underlying the signaling versatility of a muscarinic receptor regulated by orthosteric and allosteric ligands.
Pancreatic β-cell compensation is a major mechanism in delaying T2DM progression. Here, the authors show that circGlis3 levels are affected by QKI and FUS expression, and that increasing circGlis3 lengthens β-cell compensation via enhancing insulin secretion and reducing apoptosis.
RuO2 is a promising anode catalyst for proton exchange membrane water electrolyzers but suffers from poor catalytic stability. Here the authors present a rhenium-doped RuO2 with a unique dynamic electron accepting-donating that adaptively boosts activity and stability in acidic water oxidation.
The epigenomic landscape of renal cell carcinoma (RCC) remains to be explored. Here, integrative epigenomic analysis of primary human RCC samples and RCC GWAS risk SNPs identifies transcription-factor specific subtypes and enrichment of risk variants in allelically-imbalanced peaks.
Fate specification in the mammalian epiblast rely on complex interactions between morphogens and tissue organization. Here, the authors highlight epithelial integrity as a key determinant of TGF-β activity and a mechanism guiding morphogen sensing and spatial cell fate change.
Notch signaling is crucial for pancreatic cell fate choice. With mathematical modeling and experiments, Xu et al. provides new insights into how different Notch ligands and Hes1 oscillation guide the spatial-temporal dynamics of cell differentiation.
Here the authors developed a nucleolus Hi-C technique (nHi-C) for enriching nucleolus-associated interactions, and revealed specific heterochromatin interaction patterns within and around nucleoli in human cells at high resolution.
DNA-protein crosslinks (DPCs) are toxic DNA lesions which threaten genome stability. Here, the authors develop a method to track the fate of DPCs in cells and identify a role for the SPRTN protease in replication-independent DPC repair.
How complex organics form in a prebiotic world remains a missing key to establish where life emerged. The authors present a road to abiotic organic synthesis and diversification in hydrothermal contexts involving magmatism and rock hydration.
Asymmetric reduction of prochiral ketones is challenging. Here, the authors identify and solve the structure of anthrol reductase CbAR, whose variant H162F can convert 1,3-cyclodiketones and α-haloacetophenones to the corresponding chiral alcohols.
ALS is somewhat heritable, but the genetic basis is not completely understood. Here, the authors identify alterations in splicing in neurons associated with amyotrophic lateral sclerosis and uncover several associated genetic loci, with a potential link to nuclear pore defects.
A diterpenoid biosynthetic gene cluster (BGC) has been identified in a few species in the Lamiaceae (mint) family, but its origin and evolution remain unclear. Here, the authors report assembly of genomes of three species within the family and reveal the dynamic evolutionary trajectory of the BGC.
Sensory nerves are important for tissue homeostasis. Here the authors show that sensory nerves contribute to Mesenchymal stem cell maintenance via FGF1, mTOR signaling and autophagy.
Engineering Cu to achieve high catalytic selectivity towards carbon monoxide at high current density is challenging. Here, the authors report an Cu-Sb single-atom alloy catalyst that catalyzes CO2 reduction at a current density of 500 mA cm−2 with CO FE of ca. 91%.
Apical constriction is known to be critical for neural tube closure, but the signals that induce this process have not been fully characterized. Here Yoon et al. identify a signaling complex that instructs actomyosin contractions during apical constriction and show that it is required for neural tube closure.
Here, explainable deep learning and climate networks give insight into the dependencies between El Niño and river flow, with implications for machine learning-based earth system model coupling and climate-informed projections of water resources.
Delineating the specific role of Polycomb Repressive Complex 2 (PRC2) in various cancer systems is desirable as inhibitors for EZH2 inhibitors are approved for some cancers. Here the authors show haplo- and full-insufficiency of EZH2 drive divergent phenotypes in lung cancer. 3D tumoroids recapitulate transcriptional profiles, including FOXP2 derepression, and drug responses of in vivo tumors.
Mineral weathering and microbial priming are two important processes that regulate soil formation and CO2 emissions. Here the authors link weathering with primed organic matter decomposition, which plays a key role in controlling soil C dynamics.
Tuning CO2 electrocatalysis to achieve multi-carbon products is interesting yet challenging. Here the authors report a histidine-functionalized Cu catalyst for CO2 reduction to multi-carbon products and reveal the correlation between catalyst surface charge and catalytic performance.
Here the authors show that the exonuclease EXD2 is involved in the recovery of class II gene transcription after UV irradiation. EXD2 travels from the mitochondria to the nucleus to interact with RNA Pol II and degrade new synthetized mRNA to allow transcription following DNA repair.