Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Predicting the El Niño-Southern Oscillation (ENSO) since the 2000s has become increasingly challenging. Here the authors show that the Southern Indian Ocean Dipole has become a key precursor of Central Pacific El Niño since the 2000s with a 14-month lead.
South American cordilleran orogenic systems have repeated complex magmatic and deformation histories. Here the authors analyze detrital zircons found in the Amazon deep-sea fan that record mountain-building events and reveal cycles of orogenesis with periods of ~60–90 Myr since the Phanerozoic.
Switching between adhesive and non-adhesive states is important to design materials with on-demand adhesion properties but realizing reversible switching on large scale remains challenging. Here, the authors report the design of a hydrogel demonstrating rapid and reversibly switch between slippery and sticky states.
High-voltage non-aqueous lithium metal batteries suffer from poor cycling stability due to the presence of impurities in the electrolyte solution. Here, the authors report lithium hexamethyldisilazide to scavenge HF and H2O, prevent the Ni dissolution and suppress side reactions during cycling.
Here, the authors observe tightly bound, valley-polarized, UV-emissive trions in monolayer transition metal dichalcogenide transistors. These are quasiparticles composed of an electron from a high-lying conduction band with negative effective mass, a hole from the first valence band, and an additional charge from a band-edge state.
Nitrogen-fixing (diazotrophic) cyanobacteria provide a critical nutrient input to the ocean. Non-cyanobacterial diazotrophs are also thought to contribute, but they have not been observed to fix nitrogen. Using dual isotope labeling combined with nanoscale secondary ion mass spectrometry, this study demonstrates that putative non-cyanobacterial diazotrophs attached to particles can fix nitrogen.
SARS-CoV-2 vaccination has shown reduced efficacy in patients with haematological malignancies. Here, the authors show that a third vaccine is able to enhance SARS-CoV-2 antibody responses in most cases in a cohort of 381 patients with haematological malignancies.
The colonial practices of geoscience have created long term vulnerabilities to natural hazards. In this comment the ongoing consequence are explored of colonialism as well as the actions that are needed to be taken to reduce natural hazard risk.
Very little is known about biological sex differences in influenza disease outcome. In 2013, avian influenza (H7N9) infections in humans have been reported with higher frequency in men than women. Here, Bai et al. report that low testosterone levels in men correlate with poor infection outcome. They confirm the causal link between viral infection and testosterone depletion using a mouse model.
Plant viruses adopt diverse strategies to inhibit host antiviral defense. Here the authors show that multiple different effectors from various rice viruses interfere with host gibberellin signaling by targeting the DELLA protein SLR1.
Here the authors analyze the 3D genome structure of murine thymocytes and show that SATB1, a predominantly T-cell specific protein, helps to establish a regulatory, finer-scale organizational layer built upon a pre-existing chromatin scaffold mediated by other architectural proteins, such as CTCF.
Spatially resolved transcriptomics is a relatively new technique that maps transcriptional information within a tissue. Here the authors present MIST, which detects molecular regions from spatially resolved transcriptomics and denoises the missing gene expression values by region-specific imputation.
Focused-ion beam (FIB) lithography enables high-resolution nanopatterning of 2D materials, but usually introduces significant damage. Here, the authors report a FIB-based fabrication technique to obtain high quality graphene superlattices with 18-nm pitch, which exhibit electronic transport properties similar to those of natural moiré systems.
It is currently difficult to perform accurate single-cell assays in 384-well plates. Here the authors report Dye Drop which uses sequential density displacement and microscopy for multi-step assays on cells, and use this to collect single-cell dose-response data for small molecules in breast cancer cells.
The development of selective ClpP activators targeting only the MRSA isolates without interfering with the human variant is currently challenging. Here, the authors report on the structure-based design of enantiomers of ZG197 and identify the discriminator factor between the proteins.
Upward depletion of ophiolitic mantle is produced by melt-peridotite reaction with lateral melt/rock ratio variations in an asthenospheric upwelling column, which flows to become the horizontal oceanic lithospheric mantle under spreading centers.
Here authors report cryo-EM structures of IP3R1 which provide atomic details of IP3, Ca2+ and ATP binding. Molecular motions of key domains and sidechains were found to regulate ligand binding and gating, which are validated by functional assays.