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Photoelectrochemical oxidation provides a promising strategy for glucaric acid production. Here, selective oxidation of glucose to glucaric acid is realized on the photoanode of defective TiO2 decorated with single-atom Pt via a photoelectrochemical strategy.
Matrix stiffening is a quintessential feature of aged tissues. Authors show that an aged (stiff) matrix epigenetically represses the gene encoding the longevity factor, α-Klotho, resulting in chondrocyte dysfunction, a leading cause of osteoarthritis.
Madagascar is a threatened biodiversity hotspot. Here, using a newly assembled dataset and island biogeography models, the authors estimate how many millions of years of evolutionary history have been lost since human colonisation and may be further lost in the future for Malagasy mammals.
Magnetized plasmas display continuous spectra of current-sheet equilibria. How they select a particular equilibrium is not well understood. Now, equilibrium selection in magnetized plasmas is studied by analytical theory, particle-in-cell simulations and spacecraft observations, highlighting the role of current-sheet relaxation processes.
This study shows prominent synchronous co-evolution of drought events in drought hubs in sub-tropical regions, influenced by sea surface temperature patterns and teleconnections. Such simultaneous occurrence of droughts may have detrimental impacts.
Patients with cystic fibrosis are not reporting particularly sever outcomes upon SARS-CoV-2 infection. Here, the authors demonstrate decreased ACE2 levels is cystic fibrosis airway epithelia associated with impaired viral entry and replication.
Polymer-based long-acting injectable drugs are a promising therapeutic strategy for chronic diseases. Here the authors use machine learning to inform the data-driven development of advanced drug formulations.
Catastrophically mechanical failure, of soft self-healing materials often stems from its poor resistance to crack, propagation. Here, the authors present a strategy of surpassing trade-off, between soft self-healing and high fracture toughness, enabling the, conversion of soft and weak into soft yet tough self-healing materials.
Antiretroviral APOBEC3 may contribute to HIV-1 latency. In this study, Ajoge and Renner et al. identify a previously undescribed function of human APOBEC3 proteins in redirecting integrations of HIV-1 DNA into more transcriptionally inactive regions of the genome.
In decision circuits, inhibitory neurons signal animal choices. Here, the authors show that choice-selective inhibition can stabilize the circuit dynamics or promote competition depending on inhibitory output connections, affecting choice behavior.
This study reveals that air-sea heat exchange plays differing roles in the transformation of Atlantic Water along the two northward-flowing warm currents in the Nordic Seas, which needs to be considered to understand high-latitude response to climate change.
The A–B transition in superfluid 3He is a pure experimental model system to study first-order phase transitions in the early Universe. Tian et al. observe the path dependence of the supercooling of the A phase in a wide parameter range and provide explanations for the heterogeneous nucleation of the B phase.
Here, the authors report accelerated intrahost evolution of SARS-CoV-2 in an immunocompromised patient with non-Hodgkin’s lymphoma with 318 days long COVID-19, and show that changes in the viral genome resulted in escape from T cellular immune response.
The colliding ribosomes are ubiquitinated by the sensor protein Hel2, leading to noncanonical subunit dissociation by the ribosome associated quality control trigger (RQT) complex. Here the authors reveal the decoding mechanism of the ribosome ubiquitin code by the RQT complex.
Nucleosides and their analogs are pharmacologically important molecules. Here, the authors report an additive-controlled stereodivergent iodocyclization method for the selective synthesis of α- or β-nucleosides.
Absence seizures impair consciousness by an unknown neuronal mechanism. Here, the authors find that a rat absence seizure model’s behavior and hemodynamics recapitulate previously reported characteristics of human absence seizures, and uncover four distinct patterns of neuronal activity in cortex and thalamus during consciousness-impairing seizures.
Biologically inspired spiking neural networks are highly promising, but remain simplified omitting relevant biological details. The authors introduce here theoretical and numerical frameworks for incorporating dendritic features in spiking neural networks to improve their flexibility and performance.