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TRIM E3 ligases are key regulators of numerous cellular functions, yet their mechanism of action remains poorly understood. Here, the authors show that paralogous TRIM2 and TRIM3 adopt different self-association and activity profiles but interact in cells to modulate their respective activities.
Dimension reduction techniques allow to simplify complex process design and system optimization in various engineering problems. The authors propose here a machine learning approach to discover dominant dimensionless numbers and governing laws from scarce measurement data.
Interleukin-18 (IL18) has a pivotal role in interferon signalling and T cell development, but increasingly recognized as an adipokine that regulates energy metabolism in fat tissue. Authors here dissect the function of IL18 signalling in the adipose compartment by targeted genomic deletion of its two receptors individually and in combination in brown and white adipose tissues.
The viscosity of magma plays a crucial role in the dynamics of planet Earth. In this study, the authors show how transport properties of basaltic melt can give us insights into magma ocean dynamics.
The carbohydrate binding protein galectin-3 has been linked to diabetes and cancer. Here, authors show that galectin-3 is a sensor of LPS, an important modulator of the mTORC1 signaling, and a critical regulator of glucose metabolism.
The physiological role of endogenous neural protenitor cells of the subventricular zone in adult stage is not fully understood. Here the authors show that in mice, these cells tune neuronal activity of the striatum via insulin-like growth factor binding protein-like 1 and cognitive functions.
Small regulatory RNAs (sRNAs) often act in concert with the RNA-chaperone Hfq to regulate the expression of multiple target transcripts in bacteria. Here, the authors identify Hfq-interacting sRNAs and their targets in the pathogen Vibrio cholerae, including an RNA sponge that binds and inactivates four sRNAs that modulate the quorum sensing pathway.
Trypanosoma brucei parasites invade different organs, such as the central nervous system, adipose tissue, and skin in mammalian host. Here, Trindade et al. perform mathematical modelling to show that adipose tissue forms (ATFs) grow slower than the bloodstream forms and experimentally characterize the heterogeneous ATF populations and provide evidence that slow-growing forms are refractory to drug treatment.
‘Giant atom’ physics occurs when the size of the atomic system becomes comparable to the wavelength of the light it interacts with. For atoms, such a regime is impossible to reach, however, for artificial atomic systems such ‘giant atom’ physics can be explored. Here, Wang et al demonstrate giant spin ensembles, consisting of magnetic spheres coupled to a microwave waveguide.
Parapatric speciation occurs when reproductive isolation arises without full geographic isolation. Here, the authors combine genomic and phylogeographic analyses to illustrate a case of parapatric speciation attributed to climate change, range expansion and mating system shift.
Submarine fans play an important role in routing sediment in continental and deep water settings. Here the authors develop a framework is to explain the shape of submarine fans using a numerical model framework which can either predict seafloor topography from turbidity current flow properties or infer these flow properties from seafloor topography.