Browse Articles

In this study, the authors use a global dataset of satellite-derived shoreline positions, and demonstrate that their interannual evolution is dominated by El Niño through its worldwide influence of sea level, river discharge and ocean waves

Here the authors study diet-induced weight gain/loss to identify chromatin architectures in adipose tissue (AT) associated obesity in a pig model. They found parallels and species-specific regulatory elements in humans and pigs that underpin AT specialization.

Myosin A (PfMyoA) is essential for the pathogenesis of Plasmodium falciparum, the causative agent of malaria. Here we decipher the mechanism by which a small molecule inhibitor (KNX-002) of PfMyoA impedes its motor activity.

O-methylated stilbenes are promising nutraceutical candidates. Here, the authors reveal that sorghum and wild sugarcane accumulate different types of O-methylated stilbenes due to major differences in catalytic regioselectivities of O-methyltransferases.

This paper presents a method for quantifying the benefits of beaches in reducing storm and long-term coastal flood risk. This method can contribute to cost-effective decision-making on climate change adaptation in many of the world’s coasts.

Bound-states-in-the-continuum (BICs) display unique features like symmetry protection from dissipation, long lifetimes and topological charges. Here the authors demonstrate anisotropic Bogoliubov excitation spectrum of polariton condensate from a BIC using a patterned semiconductor GaAs/AlGaAs waveguide.

Therapeutic antibody discovery is time and cost-intensive. Here, the authors develop a machine learning-driven method enabling accelerated design of large and diverse single-chain variable fragments with high binding efficiency, especially at high levels of diversity.

Phase change materials (PCMs) are promising for low-power programmable photonic circuits. Here, authors show electrically controlled wide-bandgap PCM antimony sulfide achieving low loss, high cyclability and up to 32 levels, and post-fabrication trimming is also demonstrated.

Changes in Psoriasis and other inflammatory skin diseases during severity stages can be investigated using single cell and spatial transcriptomics. Here the authors compare different inflammatory skin diseases to emphasise differences in immune cells and inflammatory markers particularly keratinocytes and fibroblasts.

Protein glycosylation plays a vital role in antigen recognition and immune modulation. Here, the authors present a computational workflow for identifying glycosylated peptides from mass spectrometry-based immunopeptidome data and investigate the properties of glycosylated MHC associated peptides.

Phase change material for solar-thermal energy storage is widely studied to counter the mismatch between supply and demand in solar energy utilization. Here, authors introduce optical waveguide to regulate the solar-thermal conversion interface to enable the fast energy harvesting in solar-thermal energy storage system.

The p38α protein kinase is an attractive druggable target for many human diseases. Here, the authors show how the structural plasticity of p38α can be leveraged to selectively inhibit a subset of the functions regulated by this kinase and aid in the development of therapeutic compounds.

Predicting the evolution of engineered cell populations is an increasingly popular topic in biotechnology. Here the authors build a model that explores evolution in engineered cell populations which can generate hypotheses that could lead to important insights into strategies for assessing and mitigating the effects of evolution.

The selective transformation of a less reactive carbonyl moiety in the presence of more reactive ones can realize straightforward and environmentally benign chemical processes but such a transformation is highly challenging. Here, the authors report an Ir catalyst for the selective hydrogenolysis of urea derivatives, which are the least reactive carbonyl compounds, affording formamides and amines even in the presence of more reactive carbonyl groups such as ester.

Patients with non-small cell lung cancer (NSCLC) with EGFR exon 20 insertions are resistant to early generation EGFR tyrosine kinase inhibitors (TKI). Here, the authors report the safety and preliminary efficacy of a phase I clinical trial JMT101, an anti-EGFR antibody, combined with EGFR-TKI, afatinib or osimertinib, in patients with NSCLC.

While over 99% of coastal arctic rivers drain small catchments, future projections of land-ocean fluxes are based on data from large rivers. We encourage inclusion of and increased focus on smaller catchments to support representative assessments of arctic ecosystem change.

In this Comment, the authors discuss the current status, the challenges, and potential technological impact of exciton transport in transition metal dichalcogenide (TMD) monolayers, lateral and vertical heterostructures as well as moiré excitons in twisted TMD heterostacks.

An energy-efficient physical reservoir is crucial for reservoir computing (RC). Here the authors demonstrate an all-electric skyrmion-enhanced strain-mediated physical RC system and achieve a benchmark chaotic time series prediction.

Understanding the impact of anti-cancer therapies on cell cycle progression could contribute to the discovery of effective therapeutic treatments. Here, the authors use genetically engineered breast cancer cell lines and computational models to analyse drug effects on specific cell cycle phases and identify effective combination treatments.

Few therapeutic strategies are able to upregulate gene expression. Here, the authors developed an approach to activate expression of human genes through small molecules and antisense oligonucleotides that modulate splicing.