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Periodic perturbations and guided mode engineering into Brillouin zone folding-induced bound states in the continuum resulted in ultrahigh Q factors that are both robust and sustainable across a broad range of tunable momentum space.
Carbon dioxide conversion into chemicals is essential for carbon capture and utilization. Here, the authors present a novel iron-based catalyst, synthesized from the thermal treatment of a parent metal-organic framework (MIL-88B), to produce a dual-active site for carbon dioxide reduction into acetic acid.
The development of a new smallsample learning framework, KprFunc, leads to the discovery of an important role for lysine propionylation in determining global protein homeostasis, mediated by a critical propionylation site on histone H2B, H2BK17pr.
In a multicenter randomized trial, researchers found that electronic alerts increased the rate of discontinuation of potential nephrotoxins. This did not translate into improved clinical outcomes, except among those exposed to proton-pump inhibitors.
The cryo-EM structure of the highly potent malaria antibody L9 reveals a key role of light-chain derived homotypic interactions in antigen binding and parasite inhibition, enabling antibody engineering and next-generation malaria vaccine design.
A peptide was developed that binds to calprotectin, a marker of major inflammatory disorders, and found to be suited for diagnostic tests. The use of synthetic peptides in assays is of great interest due to their high precision, robustness and low price.
Cellular redox homeostasis is important when responding to environmental changes. Here, the authors demonstrate APT1 is a redox sensor in plant defense and identify a pathway for oxidative stress resistance.
This study presents a global analysis of the sensitivity of inundated areas and population exposure to varying flood event magnitudes globally for 1.2 million river reaches. The authors show that topography and drainage areas correlate with flood sensitivities as well as with societal behavior.
Indoxyl sulfate is a key risk factor in the progression of chronic kidney disease, but cannot be removed from the blood by hemodialysis. Here, the authors report the use of a covalent organic framework for the removal of indoxyl sulfate precursor from the intestine.
A paper led by Prof. Zhang evaluates the value chain carbon footprints of Chinese listed companies. The results could encourage collaborative climate actions along value chains and help investors understand the environmental impacts of their investment.
Competition between agriculture and land conservation may hinder climate and biodiversity targets. Here, the authors use global models integrating multiple spatial scales to assess how ambitious land conservation action and associated land-use dynamics could drive changes in landscape heterogeneity, pollination supply and soil loss.
Early warning of the airflow separation and monitoring of the stall status is critical for the safety of flying aircraft. Here authors introduce a lightweight and conformable system on the wing surface of aircraft that can sense and warn the pre-stall.
Parkinson’s disease (PD) is linked to environmental factors. Through quantitative epidemiology, this study ties 53 pesticides to PD. An innovative human stem cell platform revealed that 10 of these were directly toxic to human dopamine neurons.
Preparing heterogeneous hydrogels with distinct phases is desirable for the mimicking of biological tissues, but generally requires complex techniques. Here, the authors report a method that uses phase separation to fabricate two-aqueous phase soft materials with distinct properties at different length scales.
Health care workers were at high risk of SARS-CoV-2 infection in the early stage of the pandemic, and this had knock-on effects including secondary infections and disruptions in health service delivery. Here, the authors estimate the economic impacts of SARS-CoV-2 infections in health care workers at the society level in five low- and middle-income country settings.
Risk assessment of lung disease mortality is currently limited. Here, authors show that deep learning can estimate lung disease mortality from a chest x-ray beyond risk factors, which may help to identify individuals at risk in screening and cancer populations.
XBB is the first recombinant, globally dominant variant of SARS-CoV-2. Here, the authors examine the variant’s origins and virological properties, showing it is the first example of SARS-CoV-2 improving its fitness through recombination.
YAP signaling has been established as a mechanotransductive pathway in multiple contexts, but its developmental roles are still being explored. Here they show that YAP signaling sustains intracellular tension to direct cell migration during embryonic axis assembly.
The duration and strength of protection against SARS-CoV-2 infection resulting from a booster vaccine dose or breakthrough infection are not well understood. This study uses data from the UK COVID-19 Infection Survey to investigate correlates of protection against Omicron BA.4/5 infection and assess antibody responses to booster vaccination and breakthrough infections.