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Equatorial Atlantic sea-surface temperature anomalies force an eastward propagating atmospheric Kelvin wave, enabling the Atlantic to impact the Pacific, with the interaction of the Kelvin wave and the Maritime Continent critical in this teleconnection.
SARS-CoV-2 genome turnover is mediated by its N protein, but precise parameters driving the necessary RNA specificity have remained enigmatic. Here, Korn et al. reveal N’s N-terminal domain to distinguish regulatory viral RNA motifs with a preference for transiently folded elements of functional impact.
Coherent Stokes Raman scattering (CSRS) has never been explored previously for chemical imaging due to a strong fluorescence background. Here, the authors demonstrate the first fluorescence-free CSRS laser scanning microscope and predict CSRS’ unique backscattering properties.
Patients with a mutant thyroid hormone receptor α1 are treated with high-dose thyroxine, but their heart rate remains low. Here, the authors show that the mutant receptor triggers cardiac reprogramming in the embryo, which prevents the response of specific ion channels and heart rate to the hormone.
The authors highlight the importance of kinetics in GPCR activation. Using solution NMR, they show that the transducer βarrestin1 and the β-arrestin1biased ligand ML314 kinetically tune the conformational ensemble of the neurotensin receptor 1.
DNA methylation analysis is a promising method to detect liver cancer. Here, the authors develop a 5 CpG site signature which can detect HCC at high specificity across multiple cohorts.
CLE19 is a secreted peptide required for pollen development and other processes in Arabidopsis. Here the authors show that PXL1 and SERKs act as receptors and co-receptors for CLE19 and regulate tapetum transcriptional networks that promote pollen development.
The authors examine how the brain processes actions performed by humans and events involving objects. Their findings suggest that a common neural code is used in the brain’s action observation network to represent event information, regardless of animacy.
Improved biomarker-based tools for diagnosis and risk prediction of venous thromboembolism (VTE) are needed. Here, the authors show that Complement Factor H Related 5 protein, a regulator of the alternative pathway of complement activation, is a VTE-associated plasma biomarker in 5 independent cohorts.
Silica glass is a high-performance material used in most branches of society from glassware and windows to optical lenses and fibers. Here, we develop a sintering-free method for 3D printing silica glass with sub-micrometer resolution and successfully demonstrate an optical microtoroid resonator.
A deep understanding of multi-level assembly structures of conjugated polymers is crucial for developing high performance conjugated polymers and optoelectronic devices, however, it remains a challenge. Here, the authors report the morphological evolution of multi-level assembly of a model system of isoindigo-based conjugated polymer.
HER2 amplification in metastatic colorectal cancer (mCRC) identifies a group of patients with poorer prognosis. Here, the authors report the results of a phase II clinical trial assessing the clinical response and safety of trastuzumab deruxtecan as a third-line treatment in patients with mCRC with different HER2 expression levels
Conventional alkaline and neutral CO2-to-CH4 systems suffer carbon loss, and recovering the lost carbon requires input energy exceeding the heating value of CH4. Here, the authors report a chelating strategy to obtain Cu-N/O single sites decorated Cu clusters, which enables energy- and carbon-efficient CH4 electroproduction in an acidic system.
Preparation of porous liquids are fluids with the permanent porosity still requires complicated and tedious use of porous hosts and bulky liquids. Here, the authors develop a facile method to produce a porous metal-organic cage liquid by self-assembly of long polyethylene glycolimidazolium chain functional linkers, calixarene molecules and Zn ions.
The proximity effect in semiconductor-superconductor nanowires is expected to generate an induced gap in the semiconductor. Here, the authors study the superconducting proximity effect in InSb nanowires with an Al/Pt shell, demonstrating control of the induced gap using electric and magnetic fields.
Eye tracking systems are crucial for eye health-monitoring and human-machine engineering. Here, Shi et. al. report a transparent and flexible active eye tracking system based on an electrostatic induction effect, enabling visual preference analysis and eye-controlled human-computer interaction.
Intense laser interaction with matter creates plasma which can act as a nonlinear optical medium. Here the authors demonstrate plasma as a refractive optics for relativistic intensity radiation, evident by the acceleration of multiple electron beams from a single laser pulse passing through the plasma.
Incorporating cyanoalkyl moieties into amino acids and peptides is of interest for potential imaging and therapeutic purposes. Here, the authors developed a Cu-catalyzed asymmetric cyanoalkylation of glycine derivatives for the synthesis of α-cyanoalkylate amino acids and peptide modification.