Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Removing ice from surfaces typically requires melting. Nonetheless, authors demonstrate a smart low interfacial toughness coating integrated with underlying heaters and ice-detecting microwave sensors that enable energy efficient smart large-scale de-icing without melting.
P1B-type ATPases export excess transition metals from cells. Here, the authors report a molecular structure of CopA, a coppertransporting P1B-ATPase from A. fulgidus, in an inward-facing E1 conformation.
Ribonuclease P efficiently processes all tRNA precursors despite sequence variation at the site of cleavage. Here, authors use high-throughput enzymology and cryoEM to reveal conformational changes that drive recognition by bacterial RNase P.
Long-term records from boreal streams indicate strong seasonal redistributions of dissolved organic carbon concentrations and quality linked to the severity of summer drought conditions
Worst pattern of invasion (WPOI) is a parameter used to quantify tumor invasiveness of oral squamous cell carcinoma (OSCC). Here the authors show that a fibroblast subset characterized by the expression of the oxytocin receptor is enriched in highly invasive WPOI 4-5 OSCC tumors and can be targeted to reduce the desmoplastic stroma and tumor metastasis.
Freestanding perovskite oxides pave the way to novel flexural properties. Here, the authors observe the nanoscale strain gradient induced flexoelectric polarization with an unusual flexo-expansion/shrinkage effect in freestanding ferroelectric oxide.
Electrocatalytic reduction of CO2 into multi-carbon alcohols of high economic merit offers an effective means to close the carbon cycle. Here the authors show the synergy between inorganic and organic phases derived from rationally designed molecular precursors to produce alcohols in high efficiency.
Isotope fingerprinting is used to track precursor sources and formation pathways of aqueous SOA, such as oxalic acid, finding that fossil fuel precursors contributions have largely been underestimated.
Regulatory T (Treg) cells have been implicated in the induction of airway tolerance and amelioration of respiratory duct inflammation. Here the authors show, using PD-L2 deficient mice, that the immune suppression signal from PD-L2 is important for modulating Treg cell metabolism and function for proper induction of respiratory tolerance in mice.
High-spectral-purity frequency-agile room-temperature THz sources are foundational elements for imaging, sensing, metrology, and communications. Here a parametric oscillator-photomixer chip with coherent 2.8-octave tunable THz radiation is achieved.
Single-wall carbon nanotubes are made of carbon with diameters less than 100 nanometers. Here, the authors engineer an analogue tube with a diameter 1,000,000 times larger with the aim to explore topological properties including unusual acoustic edge states.
Nanocrystals are desirable light sources for advanced display technologies. Here, the authors report on double-crowned 2D semiconductor nanoplatelets as light downconverters that offer both green and red emissions to achieve a wide color gamut.
Glycosaminoglycans (GAGs) are highly anionic functional polysaccharides with subtle structural variations that are very difficult to differentiate. Here the authors demonstrate proof-of-concept single-molecule detection by nanopore, taking a first step towards the ultimate goal of GAG sequencing.
Pseudomonas aeruginosa infections are increasingly difficult to treat due to the development of antimicrobial resistance. Here, the authors describe the synthesis, characterisation and efficacy of a quorum sensing inhibitor.
Development of methods for simultaneous single cell analysis of transcription and translation is still underway. Here, Hu et al. develop single-cell transcriptome and translatome dual-omics on human oocytes, which enables them to identify OOSP2 as an induction factor during human oocyte maturation.
Thermochemical redox reactions of metal oxides are promising for CO2 capture, gas purification, air separation, and energy storage. Here, the authors report mixed metal oxides derived from layered double hydroxides precursors, and demonstrate their reversible and stable thermochemical oxygen storage.
Accurate classification of genetic variants is critical for research and patient care. Here, the authors report that population-based associations between rare variants and quantitative endophenotypes for monogenic diseases can provide support for variant pathogenicity.
Repurposed antiviral drugs present as a valuable resource in the defence during outbreaks, with rigorous evaluation in large animal models keys for translation to clinical implementation. Here, the authors explore the antiviral activity of favipiravir against Zika virus and SARS-CoV-2 in cynomolgus macaques, in order to support future clinical investigations into this RNA polymerase inhibitor.
Mitochondrial tRNAs are indispensable and yet underwent an extreme mutational erosion. The authors report the structures of a mitochondrial aaRS-tRNA complex and show how the most degenerated of all human mtRNAs is recognized by its cognate synthetase to maintain mitochondrial gene expression.
Conventional X-ray-induced photodynamic therapy usually requires heavy-metal-containing inorganic scintillators and organic photosensitizers to generate singlet oxygen. Here, the authors develop an organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy of deep tumours.