Browse Articles

Scientists have been puzzled by the disparity between climate simulations of the past 12,000 years and geological records. Dong et al. reconstructed past annual and seasonal temperatures from land snail records to examine the potential seasonal bias.

Structural biology, complemented by biochemistry experiments and RNA-binding assays show that the Gemin5 C-terminal region adopts a decamer architecture. Gemin5 decamerization is essential for its role in regulating mRNA translation.

Phosphate is critical for all life on Earth but its origins have remained enigmatic. Experiments indicate that phosphate may have been abundant in ancient Fe-rich seawater, providing a crucial ingredient for the origins of life on Earth.

Salvinia molesta plant has the ability to maintain a stable air layer when submerged underwater due to its specific form. The authors propose here a soft lithography fabrication method of artificial Salvinia leaf assisted with capillary-force induced clustering of micropillar array, for hydrodynamic drag reduction.

The Spns lipid transporters use ion gradients to drive substrate transport, including bioactive sphingolipids. Here, Dastvan et al. investigated how binding of protons powers the conformational changes that enable broad transport by a bacterial Spns.

A general synthetic solution toward high-oxidation state securinega alkaloids could be useful for systematic biological studies. Here, the authors report a divergent synthesis of C4-oxygenated securinega alkaloids via stereocontrolled diversifications on the piperidine core.

Volumetric functional imaging is widely used for recording neuron activities in vivo for many experimental organisms. Here the authors report supervised deep-denoising methods for improved whole-brain imaging, large field-of-view imaging in freely moving animals, and recovering complex neurite structures in C. elegans.

Circulating subtypes of Influenza viruses seasonally change and therefore vaccines need to be matched to these strains each year, which is why there is a need for next-generation vaccines that can elicit broad and cross-type protection. Here, Li et al. generate a human-mouse chimeric antibody with broad neutralizing activity against seasonal and pandemic H1N1 and some H5N1 viruses in vivo and identify residues on hemagglutinin relevant for its broad neutralization activity.

When a molecule interacts chemically with a metal, its orbitals hybridise with metal states to form the new eigenstates of the coupled system. Here, the authors show that in addition to overlap in real space and energy, hybridizing states must fulfil a momentum-matching condition.

A short isoform of the Tet1 enzyme (Tet1s) that oxidizes the DNA 5-methylcytosine (5mC) mark is overexpressed in tumors. Here the authors show Tet1s, but not full length Tet1, changes localization over the cell cycle upon ubiquitination and Uhrf1 interaction and is targeted to heterochromatin during S-phase. This leads to 5mC oxidation and loss of DNA methylation in heterochromatin.

How animals are able to rapidly adapt their behaviour to changing environmental demands remains poorly understood. Here, the authors use a modelling approach to show that synaptic plasticity in motor cortex may underlie rapid motor learning, demonstrating that small, correlated connectivity changes that preserve neural covariance are highly effective in driving behavioural adaptation.

Assessing metabolic activity within single cells rather than at a population level has a number of advantages. Here, the authors use a flow and mass cytometry based approach that assess the metabolic differences between populations of human immune stimulatory and tolerogenic dendritic cells.

Here, the authors demonstrate multipath twisting of acoustic waves with a thin metamaterial layer enabling high-speed transfer of information with no time-consuming post-processing or sensor scanning, showing important application potential in underwater communication.

The single stranded DNA binding protein RPA coordinates DNA metabolism using multiple protein and DNA interaction domains. Here, the authors show that the chaperone-like protein Rtt105 staples RPA domains to prevent untimely protein interactions.

Traumatic brain injury can cause long-term disability and thus constitutes a substantial healthcare burden worldwide. Here, the authors report a conductive microporous hydrogel to improve angiogenesis and recovery of brain function in traumatic brain lesions.

Researchers have been trying to mimick the cellular spatiotemporal control in normal cells with different approaches. Here, the authors present semi-permeable polymersomes comprising of amphiphilic triblock copolymers to achieve external signal-driven complex coacervation and biophysical reconstitution of cytoskeleton.

Ancient drip water in a Borneo stalagmite reveals a strong land temperature rise across the last glacial termination in close correspondence with atmospheric CO2, and an intriguing decoupling between tropical temperature and hydroclimate.

This study presents a large-scale analysis of microbial diversity in deep-sea sponges. They show that sponge microbial abundance status, geographic distance, sponge phylogeny and the physical-biogeochemical environment drive microbiome composition, in descending order of relevance. The uniqueness of each deep-sea sponge ground stresses the need for their strategic preservation.

High power efficiency and low roll-off values are essential to the commercialization of white organic light-emitting diodes. Here, the authors construct all-fluorescence devices with an orange emitting layer sandwiched between two sky-blue emitting layers, achieving figure-of-merit of 130.7 lm/W.

Laser probing of integrated circuits using sub-bandgap photon energies remains a challenge. Here, the authors propose a super-resolution method capable of achieving probe placement accuracy to better than 10 nm; extraction of electro-optic waveforms from a node of a group of transistors and applied this to isolate and identify a fault on a defective device.