Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Epithelial-to-mesenchymal transition (EMT) is a complex process regulated at multiple molecular levels. Here, the authors implement an analytic framework - PAMAF - to integrate data from twelve distinct omics modalities, which they use to understand the molecular changes and regulation during EMT in vitro.
Halide perovskites have a variety of attractive feature such as high quantum yield, and tunable optical properties, combined with easy fabrication. Here, Kirstein et al demonstrate spin-mode locking in CsPb(Cl0.56Br0.44)3 lead halide perovskite nanocrystals embedded in a fluorophosphate glass matrix, and a hole spin lifetime extending into the microsecond range.
A possible route to scalability of trapped-ion-based quantum computing platforms is to connect multiple modules where ions can be shuttled across different registers. Here, the authors demonstrate fast and low-loss transfer of trapped ions between two microchip modules.
Although anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis and generally considered pathogenic, their functional relevance is incompletely understood. In this study, the authors describe an ACPA with a protective effect against antibody-induced arthritis in mice.
Human acetyltransferases MOZ and MORF mediate development programs and are dysregulated in diseases. Here the authors identified two winged helix (WH) domains in MORF/MOZ and characterized their DNA binding functions, including targeting of CpG by WH1.
Heart fibrosis involves a feedback loop where stiffening increases fibrosis-related gene expression in myofibroblasts. Here authors reveal the mechanosensitive nuclear translocation of VGLL3, where it phase separates and promotes collagen production, and show that its knock-out is protective after myocardial infarction.
Long lasting insecticide treated mosquito nets (LLINs) provide protection from malaria through both direct effects to the user and indirect community-level effects. Here, the authors use mathematical modelling to assess the relative contributions of these effects under different insecticide resistance and LLIN usage scenarios.
Immune checkpoint inhibitors with or without chemotherapy are now standard of care for non-small cell lung cancer. However, the benefits of combination vs sequential therapy have not been fully explored. Here, the authors analysed 1,133 patient records and show combination therapy showed increased protection against early progression, but similar overall survival.
Here, Rouet et al. present a strategy for the identification of broadly neutralising antibodies against SARS-CoV-2 receptor binding domain from peripheral blood mononuclear cells of convalescent patients, which enabled the identification of a new class 6 epitope.
Genome editing in bacteria normally requires efficient recombination and high transformation efficiencies, which often isn’t. Here the authors report that systematically attenuating DNA targeting activity enables RecA-mediated repair in different bacteria, allowing chromosomal cleavage to drive editing.
Kagome metals continue to attract interest due to the coexistence of electronic correlations and band topology. Here the authors use proton gating to modulate disorder and carrier density in CsV3Sb5 nanoflakes, and show its effect on superconductivity, charge density wave and anomalous Hall effect.
Deubiquitinases (DUBs) are key signaling enzymes, many of which lack selective inhibitors. Chan et al. pair a DUB-focused covalent library to mass spectrometry activity-based protein profiling, leading to selective hits against 23 endogenous DUBs and a first-in-class VCPIP1 probe with nanomolar potency.
Carbon dioxide removal technologies are gaining prominence in academia, industry and policy, yet the need for substantial funding raises serious challenges. This comment discusses these issues and offers suggestions for future funding efforts in this area.
Climate change is an expensive collective problem that will be felt unequally around the world and within communities. Sustainable and equitable financing is needed to address disparities and reduce the economic costs of loss and damage from climate change.
2D metallenes have spurred considerable interests in heterogeneous catalytic reactions. Here the authors report an efficient galvanic replacement strategy to construct Pd metallenes mediated by Nb2C MXenes for boosting alkynes semihydrogenation.
The tension between measured W mass and its Standard Model prediction might arise from uncertainties in the hadronic contribution, and the same is true for the muon g − 2. Here, the authors show that such a common origin for the two anomalies is unlikely, while a model involving leptoquarks might explain them both.
The shape and size of the mature central nervous system is highly regular, implying precise architectural rules. The authors show that alterations in JNK signaling in selected neurons impact the overall 3-dimensional organization of the Drosophila ventral nerve cord in a cell non-autonomous fashion.