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Organic room-temperature phosphorescent (RTP) materials exhibiting stimuli responsive reversible changes in optical properties show great potential in diverse optoelectronic fields but a lack of mechanistic understanding limits their development. Here, the authors prepare a series of RTP polymers by incorporating phosphorescent rotors into polymer backbones and demonstrate colortunable persistent luminescence upon excitation at different wavelengths
Idiopathic pulmonary fibrosis is a disease caused by persistent micro-injuries to the lung ultimately resulting in death. Here, the authors describe the use of a small molecule OGG1 inhibitor, TH5487, as a potent and potentially clinically relevant treatment for IPF.
Inter-organellar contacts are hubs for several critical cellular processes, such as lipid synthesis. Here Ganji et al. show that the p97-UBXD8 complex modulates contacts by regulating membrane lipid composition and saturation.
The large radius of potassium ions inevitably destabilizes the crystal structure of the cathode material in potassium-ion batteries, leading to capacity degradation. Here, authors demonstrate that phase-engineered amorphous vanadium oxide alleviates large volume variation and improves electrochemical behaviour.
Organoboron and organosilicon compounds have potential applications in various fields including materials science and medicinal chemistry. Here the authors report a protocol that enables the dearomative carbo-sila-boration of quinolines.
In this work, the authors use a centrifuge force microscope for high-throughput single-molecule experiments to elucidate stacking energies between individual bases of DNA.
Developing efficient strategies to realize divergent arylation of dienes has been a longstanding synthetic challenge. Herein, a nickel-catalyzed divergent Mizoroki–Heck reaction of 1,3-dienes has been demonstrated through the modification of ligands and additives.
Marchioretti and colleagues show that in the skeletal muscle of SBMA mice and patients there is an early, but reversible alteration of expression of genes involved in muscle contraction and of mitochondrial respiration, followed by accumulation of calcium inside the mitochondria, which is concomitant with the onset of motor dysfunction, and late alteration of muscle structure.
Adhesion GPCRs have numerous functions, ligands and isoforms. Here, Kordon et al. report synthetic antibodies that both modulate aGPCR signaling in an isoform-specific manner, and break receptor interactions in a ligand-specific manner
Here the authors show transposable elements, formerly considered junk DNA, are a source of CTCF binding sites that contribute to species-specific 3D-genome structure, and may impact gene regulation during the course of mammalian evolution.
The mechanisms which generate fMRI signal correlations across the brain are not fully understood. Here, the authors record ultrafast fMRI signals in anesthetized female rats to demonstrate intrinsic macroscale oscillatory modes which drive correlated activity between distant regions.
Scaled manufacturing of ordered mesoporous materials has been historically challenging. This work reports a simple and generalizable method to directly convert low-cost thermoplastic elastomers to mesoporous polymer, carbon, and silica, with controlled pore textures by altering precursor identity.
Zinc metal anodes suffer from electrolyte corrosion and dendrite growth issues during electrochemical cycling. Here, the authors propose a gradient design to imprint the zinc anode, which both prohibits side reactions and alleviates zinc deposition behaviour.
Ruthenium-based materials show promising performance for ammonia decomposition, yet the underlying mechanism remains to be further explored. Here the authors investigate atomically dispersed Ru atoms on polar (111) on MgO facets to show synergistic metal sites in close proximity are required for the stepwise dehydrogenation of ammonia to N2/H2.
Developing multi-cancer early detection (MCED) tests based on cfDNA or protein markers holds great promise for effective cancer screening. Here, the authors show a sensitive, non-invasive pan-cancer detection method that concurrently detects the oncofetal chondroitin sulfate (ofCS) glycans and its protein backbone in plasma.
Barrier-to-autointegration factor 1 (BAF) is a DNA binding protein involved in numerous pathways including transcriptional regulation, DNA damage response and nuclear assembly. Here, Broussard and colleagues characterise its role in gammaherpesvirus reactivation.
The high dark current of perovskite photodetectors hinders the full potential of perovskites as active material for X-ray detectors. Here, Jin et al. provide a strategy to reduce the dark current to zero and massively enhance the signal-to-noise ratio of perovskite X-ray detectors and photodetectors.