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Here, the authors generate a mouse line by knocking in the auxin-inducible degron tag to the SMARCA4 gene, which encodes BRG1. They suggest that BRG1 primarily contributes positively to chromatin accessibility, RNAP binding, and nascent RNA production.
Stomata function is essential for photosynthesis and the global carbon and oxygen cycles. Here, the authors report the regulatory framework that establishes rhythmic pore movements to prevent water loss at night and allow CO2 uptake during the day.
While significant progress has been made in classical Diels-Alder reactions, the use of simple and inert feedstock chemicals under mild reaction conditions still remains challenging. Here the authors present the development of catalytic asymmetric [4 + 2] dearomative photocycloaddition involving anthracene and its derivatives with alkenylazaarenes.
Extreme magnetoresistance (XMR) is the name assigned to the large and non-saturating magnetoresistance that occurs in some metals and semi-metals. In this work, the authors demonstrate the first material, PtSn4, in which XMR can be switched off by changing the direction of the magnetic field.
High-performance promoters are needed for gene drives; these are currently lacking in Drosophila melanogaster. Here the authors tested eleven Drosophila melanogaster germline promoters in several configurations and show higher drive conversion efficiency with minimal embryo resistance.
Porous materials with high strength are desirable for many applications. Here, the authors present a supramolecular metallic foam enabled by nanostructured liquid metals connected with high-density metal-ligand coordination to exhibit ultrahigh specific strength and recyclability.
IL-22RA1 is highly expressed on pancreatic islets and absent on immune cells. Here, the authors investigate its role by generating animals that lack IL-22RA1 on beta cells and reveal IL22RA1 signalling is critical for insulin biosynthesis and beta-cell health, evidenced by its regulation of MHC II expression and its suppressive effect on inflammation and cellular stress.
The transport behavior of high-entropy alloys (HEAs) remains unclear. Here, the authors explore the fundamentals of low-wear and high-conductivity refractory HEAs, examining the cocktail effect in conductivity, and highlight its potential applications in enhancing atomic-scale image resolution.
Flexible distribution networks with soft open points present a promising way to accommodate distributed generators and increasing loads. Here, authors present a multi-resource dynamic coordinated planning method, allowing allocation strategies to be determined over long-term planning periods.
A freeform multimaterial assembly process (FMAP) is demonstrated, synchronizing laser induction with 3D printing for seamlessly integrating multimaterials into 3D objects, enabling streamlined, flexible, and precise electronic device fabrication.
Here, the authors develop Topo-seq to measure the DNA topology (∆Lk) restrained by individual nucleosomes in vivo. They show that nucleosome DNA topology is imprinted by its native chromatin context and persists when the nucleosome is relocated.
This paper unveils the complexity of human immune cell splicing, highlighting cell-specific isoforms and establishing connections between alternative splicing and complex traits. These findings have implications for understanding diseases and the evolution of the genome.
Research on the Kit locus shows TAD boundary deletion may or may not trigger ectopic gene activation in different cell types, influenced by active enhancers’ position relative gene promoters.
According to conventional wisdom, angle-resolved photoemission spectroscopy (ARPES) can only measure the magnitude of the superconducting gap but not its phase. Here, the authors propose a new method to directly detect the superconducting gap phase using ARPES and validate this technique on a cuprate superconductor.
Anecdotal reports from patients prescribed semaglutide describe a reduced desire to drink. Here, the authors show that semaglutide is associated with a 50%-56% reduced risk for both the incidence and recurrence of alcohol use disorder in real-world populations.
Here, the authors suggest that molecular dysregulation on three axes may play a critical role in asthma within the African Diaspora. RNASeq and DNA methylation data are generated from nasal epithelium including cases and controls from seven different geographic sites.
Here the authors report the AI system Umol that predicts flexible all-atom structures of protein-ligand complexes from sequence information, advancing AI-driven drug discovery: accurate structures and affinity can be selected from predicted confidence metrics (plDDT).
Luminescent materials with narrowband emissions are vital for optoelectronic applications. Here, the authors achieve room temperature phosphorescence with a FWHM of 30 nm through the multiple resonance effect and showcase its practical application in X-ray imaging.
The specificity of protein deubiquitination relies on deubiquitinase-substrate interactions (DSIs). Here, authors leverage evolutionary information from the proteome to predict DSIs, even with an inadequate training dataset.
Membrane fusion is crucial for fabricating artificial membranes. Here, the authors present an approach combining electric field with hydraulic pressure to physically control the fusion, enabling tuning of the shape and size of the 3D freestanding lipid bilayers in physiological solutions.