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Current methods for analysing protein structures and interactions generally require the separation of specific organelles or changes to the intracellular environment. Here, authors developed nanocarrier-based cross-linking mass spectrometry techniques to assess mitochondrial proteins within living cells.
Prenylated and reverse-prenylated indoline alkaloids are widely present in nature. Here, the authors demonstrate a tandem photoredox radical dearomatization/Claisen rearrangement of electron-deficient indoles for the rapid assembly of these privileged scaffolds.
The function of TRPA1 channels in the mammalian cochlea is poorly understood. Here, the authors show that TRPA1 channels in supporting cells of the organ of Corti mediate contractile responses that may contribute to temporary shifts in hearing thresholds after noise exposure in mice.
Accurate prediction of peptidic hydrogels could prove useful for diverse biomedical applications. Here, the authors develop a “human-in-the-loop” approach that integrates coarse-grained molecular dynamics, machine learning, and experimentation to design natural peptide hydrogels.
The genomic underpinnings of cave-related phenotypes are underexplored. Here, the authors investigate adaptation to underground life in cave beetle lineages using transcriptomic and genomic data, finding both parallel and convergent changes in six independent episodes of subterranean colonization.
Gastric progenitor cells are essential for tissue homeostasis of the stomach. Here, using single-cell RNA sequencing and gastric organoid experiments, the authors demonstrate that EGFR signaling promotes gastric progenitor cell differentiation.
MBD proteins are integral subunits of the NuRD complex, a crucial regulator of cellular differentiation. Here the authors systematically dissect which MBD protein domains and isoforms are essential for neuronal differentiation.
The immune responses to SARS CoV-2 infection in children are less well understood than in adults. Here the authors characterise immune responses to newer omicron lineages and relate these to previous infection with earlier lineages of SARS-CoV-2, implicating a reduced immunogenicity from omicron variants and imprinting from previous virus strains.
The isolation of graphene leads to a surge of interest in two dimensional materials, and recently, ferromagnetism has been observed in several two-dimensional materials. However, two-dimensional ferromagnetism remains rare. Here, Gong et al present an alternative approach to achieve two-dimensional ferromagnetism; combining antiferromagnetic FePS3 with non-magnetic WS2 they find a ferromagnetic state forms at the interface of these two materials.
Laboratory experiments demonstrate that prior to fast laboratory earthquakes the fault begins to unlock and creep, causing foreshocks to coalesce in both space and time. This demonstrates that the evolution of foreshocks is closely connected to the fault slip velocity.
Cortical representations exhibit variable levels of stability, potentially impacting learning. Here, using an optogenetic cortical microstimulation task, the authors show that faster learning takes place in mice with more stable microstimulation responses.
Microsatellites are tandem repeats of short DNA motifs and represent some of the most polymorphic sites in the genome. Here, the authors report that the human germline microsatellite mutation rate is, in part, under genetic control.
There are different quantum algorithms developed for the security of current cryptographic concepts. Here the authors demonstrate a method to perform quantum-secured digital payments using unforgeable quantum cryptograms over an optical fiber link and verify the information-theoretic security.
Characterising the molecular profile of soft tissue sarcomas (STS) remains critical. Here, the authors analyse samples from 321 STS patients across 11 histological subtypes using proteomics and identify prognostic signatures that can be applied to multiple subtypes.
Estimates of COVID-19 impacts in many low- and middle-income countries remain very uncertain, with lack of high-quality data. Here, the authors reconstruct epidemic dynamics in Lusaka, Zambia and estimate that, when accounting for demographic patterns, the epidemic severity is comparable with global norms.
The Debye interaction is defined as the attraction between a polar molecule and a nonpolar molecule, which governs many self-assembling processes in materials. Here, Lee et al. design a like-charged colloidal model at the water-oil interface to characterize the Debye interaction for the first time.
This study tracks changes in post-fire hydrology in the San Gabriel Mountains, California, USA, and finds that rapid infiltration and storage of subsurface water in burned catchments contributes to increased streamflow during storms.
Projecting regional hydrological response to climate change has been a longstanding challenge. By using the dominant precipitation modes as “fingerprints”, this study shows the robust Asian monsoon rainfall response to anthropogenic warming.
People are thought to engage a retrieval brain state when they bring to mind past experiences. Here, using multivariate pattern classification analyses across experimental paradigms, the author shows that internal attention is a central process of the retrieval state.