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CpcL-phycobilisome (PBS) is a type of small PBS that transfers energy directly to photosystem I (PSI) without a core structure. Here the authors combine cryo-electron microscopy and ultrafast spectroscopy to explore energy transfer pathway in CpcL-PBS.
Moisture sorption is a common occurrence in polyelectrolyte systems, but not yet fully understood. Here the authors, combining thermogravimetric analysis, vibrational spectroscopy, molecular force field and quantum chemical computations, provide insights into the binding of water in monovalent conjugated polyelectrolytes, establishing a model of the surface hydration of the ion clusters.
Huntington’s disease is caused by mutation in the HTT gene. Here, the authors screen for suppressors of mutant HTT-induced toxicity, identifying Mtf1. Mtf1 reduced oxidative stress and cell death in stem cells, and motor defects and protein aggregates in mouse models.
Cyclic peptides are of interest due to their application in pharmaceutical industry, but currently there are limited methodologies for their synthesis. Here, the authors report an efficient and direct peptide cyclization via rhodium(III)-catalysed C(7)-H maleimidation.
Compared to germinal centres, extrafollicular plasmablast responses are thought to produce lower affinity antibodies, offering little protection from infection. Here authors show in an influenza infection and immunization mouse model that extrafollicular responses could yield protective antibodies, and that their development depends on signals provided via Toll-like receptor stimulation.
HCV vaccine development has been challenged by difficulties in the biochemical preparation of E1E2 ectodomains. Here, the authors structurally characterize an engineered soluble E1E2 ectodomain complexed with broadly neutralizing antibodies, revealing it adopts a native fold amenable for vaccine design.
Miniature asymmetric supercapacitors have higher voltage and energy density but are often limited by a complex manufacturing process and difficulties in further miniaturization. Here, the authors demonstrate a maskless method for the patterned fabrication of submicron-scale symmetric and asymmetric supercapacitors.
In observational contextual fear conditioning (OCFC), animals learn to fear the context in which they witnessed a demonstrator’s aversive experience. Here, the authors show that recall of OCFC relies on different brain areas, depending on recency of the experience and the observer’s current context.
Current clinical methods for assessing kidney function report an aggregate value for both kidneys, and lack the ability to say which kidney is dysfunctioning or even to localize the dysfunction to a region of renal pathology. Here, the authors show that an injectable dye can be used to map kidney function by magnetic resonance imaging, offering a safer alternative than existing dyes for the spatial evaluation of kidney health.
Whether fear memories can be attenuated through on demand electrical stimulation remains unclear. Here, the authors demonstrate that fear extinction can be augmented through closed-loop stimulation of the reward system, guided by hippocampal SWRs.
Generalization - that is, the ability to extrapolate from training data to unseen data - is fundamental in machine learning, and thus also for quantum ML. Here, the authors show that QML algorithms are able to generalise the training they had on a specific distribution and learn over different distributions.
Understanding molecular processes behind variable clinical features of Parkinson’s disease is valuable. Distinct molecular patterns in the brains, reflected in the blood, reveal mechanisms linked to clinical diversity in cognitive and motor decline.
Identifying KRAS-specific vulnerabilities helps to target KRAS-driven cancer. Here the authors perform RNA interference screens in 3D cultures of primary tumour cells with KRAS activation and p53 loss and identify UHRF1 as a vulnerability of KRAS-mutant lung cancers
Metal-free versions of azide–alkyne cycloadditions could find widespread applications in biomedical contexts. Here, the authors report an assembly-driven, regioselective azide–alkyne cycloaddition.
Fatty acids are fundamental biomolecular building blocks that are characterized by extraordinary structural diversity and present a formidable analytical challenge. Here the authors introduce a discovery workflow for de novo identification that adds more than 100 fatty acids to the human lipidome.
The elementary excitations of magnets are known as magnons. Like photons, they can carry information, but unlike photons, the interactions of magnons are intrinsically non-linear, making them particularly promising for physical reservoir computing, where the non-linear response of a dynamical system is used as a computational resource. Here, Körber et al demonstrate physical reservoir computing using the magnon eigenmodes of a permalloy disc.
Mechanosensitive channels exhibit large structural variations. Here, the authors reveal that OSCA channels exhibit different oligomeric states and are gated/regulated by lipids at different locations in response to physical forces.
Petrels are wide-ranging, highly threatened seabirds that often ingest plastic. This study used tracking data for 7,137 petrels of 77 species to map global exposure risk and compare regions, species, and populations. The results show higher exposure risk for threatened species and stress the need for international cooperation to tackle marine litter.