Articles in 2020

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  • Mitochondrial metabolites contribute to more than biosynthesis, and it is clear that they influence multiple cellular functions in a variety of ways. Here, Martínez-Reyes and Chandel review key metabolites and describe their effects on processes involved in physiology and disease including chromatin dynamics, immunity, and hypoxia.

    • Inmaculada Martínez-Reyes
    • Navdeep S. Chandel
    Review ArticleOpen Access
  • Here the authors report a simple method to create a solid electrolyte interphase that is tightly anchored onto the surface of lithium metal anode. This artificial structure suppresses dead and dendrite Li and stores Li via formation of alloys, enabling impressive battery performance.

    • Rajesh Pathak
    • Ke Chen
    • Qiquan (Quinn) Qiao
    ArticleOpen Access
  • RNA-sequencing is mostly used to assess gene expression; however, it can also give information about genetic variants. Here, the authors present CaSpER, a statistical framework that utilises RNA-sequencing reads to identify and visualise CNV events by integrating transcriptome-wide expression and allelic shift profiles.

    • Akdes Serin Harmanci
    • Arif O. Harmanci
    • Xiaobo Zhou
    ArticleOpen Access
  • Damaged mitochondria are known to cause neuronal death, suggesting clearance as a potential therapy. Here, Moskal et al. show that ROCK inhibitors promote Parkin recruitment and mitophagy and have neuroprotective effects in fruit flies challenged with a toxin that induces mitochondrial damage.

    • Natalia Moskal
    • Victoria Riccio
    • G. Angus McQuibban
    ArticleOpen Access
  • It is important to analyse the local resolution of cryo-EM maps. Here the authors present MonoDir, a fully automatic and parameter free method for the directional local resolution analysis of cryo-EM maps that requires only the final map as input and they also propose indicators for assessing map quality.

    • Jose Luis Vilas
    • Hemant D. Tagare
    • Carlos Oscar S. Sorzano
    ArticleOpen Access
  • Here, the authors observe that laser illumination allows to displace a vial of nanoparticle solution over centimetre-scale distances. In order to explain this, they describe a novel mechanism for laser propulsion of a macroscopic object, based on light-induced thermophoresis.

    • Nikita Kavokine
    • Shuangyang Zou
    • Lydéric Bocquet
    ArticleOpen Access
  • Transition metal dichalcogenides demonstrate fascinating capabilities for electrocatalytic H2 evolution, although the activities vary widely depending on nanomaterial sites available. Here, authors show the grain boundaries of atomically thin MoS2 to be especially active sites for H2 evolution.

    • Yongmin He
    • Pengyi Tang
    • Zheng Liu
    ArticleOpen Access
  • Intestinal aging is associated with declines in structure and absorption of nutrients. Here, the authors show that aging related intestinal decline is mediated by activation of the mTORC1-p38MAPK-p53 pathway in intestinal stem cells and can be ameliorated by abrogating mTORC1 or p38MAPK activity.

    • Dan He
    • Hongguang Wu
    • Baojie Li
    ArticleOpen Access
  • It is interesting phenomenon that chiral order can emerge in intrinsically achiral liquid crystals. Here Čopar et al. demonstrate achiral-to-chiral transition of the nematic liquid crystals flow in microfluidic channels and their behaviour, stability, and dependence on geometric and material parameters.

    • Simon Čopar
    • Žiga Kos
    • Uroš Tkalec
    ArticleOpen Access
  • Though artificial sensory systems based on electronic devices have been realized, further transformation of data into spikes is required for neural network optimization. Here, based on NbOx Mott memristors, the authors report artificial spiking afferent nerves for accessing spiking systems and demonstrate spiking mechanoreceptor systems.

    • Xumeng Zhang
    • Ye Zhuo
    • J. Joshua Yang
    ArticleOpen Access
  • Sertoli cells and other somatic cells of the testis comprise the germ cell niche and are critical to regulate spermatogenesis. Here the authors present a method in which Sertoli cells are selectively targeted for ablation by the compound benzalkonium chloride (BC) in mice, and the spermatogenic niche is subsequently repopulated in regions that have been affected by BC treatment.

    • Tetsuhiro Yokonishi
    • Jennifer McKey
    • Blanche Capel
    ArticleOpen Access
  • Although artificial Lieb lattices have been recently synthesized, the realization of a Lieb lattice in a real material is still challenging. Here the authors use tight-binding and first principle calculations to predict tunable topology and magnetism in recently discovered two-dimensional covalent-organic frameworks.

    • Bin Cui
    • Xingwen Zheng
    • Bing Huang
    ArticleOpen Access