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Ageing affects several brain areas causing a decrease in cognitive abilities and memory. We find that increasing the endogenous potential of the hippocampus to generate new neurons throughout life rejuvenates learning and memory, indicating that neural reserves can be exploited during ageing to compensate for age- or disease-related cognitive impairments.
Bacterial biofilms rely on shared extracellular polymeric substances (EPS) and are often highly tolerant to antibiotics. Here, the authors show in in vitro experiments that Salmonella does not evolve resistance to EPS inhibition because such strains are outcompeted by a susceptible strain under inhibitor treatment.
Ribosome synthesis is a complex multi-step process. Here the authors present a method that allows the efficient isolation and characterization of the preribosomal complexes formed along the entire ribosome synthesis pathway in human cells.
The transcription factor DAF-16/FOXO mediates a wide variety of aging-preventive responses by driving the expression of stress resistance and longevity promoting genes. Here the authors show that transcriptional initiation at many DAF-16/FOXO target genes requires the dephosphorylation of SPT-5 by Protein Phosphatase 4.
Current research focus on the perovskites solar cells (PSCs) is mainly limited to the lead-based ones with bandgaps above 1.5 eV. Here Hu et al. report efficient and stable inorganic tin-containing PSCs, opening doors to exploring abundant perovskite materials with bandgaps lower than 1.4 eV.
The enzyme LspA from the human pathogen Staphylococcus aureus (MRSA) contributes to the integrity and function of the bacterial cell envelope. Here, authors provide crystal structures of LspA in complex with two natural antibiotics, which have profoundly different structures but inhibit LspA in an identical way.
Artificial receptors for chiral recognition are important in enantiomer excess analysis but current artificial detectors are based on fluorescence intensity changes only. Here the authors propose a different detection mechanism based on change of the fluorescence emission wavelength of an AIEgen rotor.
The influenza virus hemagglutinin (HA) protein is a target for antivirals. Here, using a multivalent peptide library screen, the authors identify PVF-tet as an HA inhibitor and show that the peptide inhibits IAV replication by sequestering HA into amphisomes, suggesting these to represent a type of anti-viral machinery.
The Nuclear Pore Complex has been linked to DNA damage processing. Here the authors reveal that the Nup1 C-terminus is critical for the relocalization of eroded telomeres to nuclear pores and that modification of Nup1 promotes sister chromatid recombination and unleashes a new telomere maintenance mechanism.
Neurons are subjected to strains due to body movements and their locations within organs and tissues. Here the authors show that UNC-70/β-spectrin and TBC-10 dynamically maintain attachment of the axon within the epidermis non-cell-autonomously by stabilizing hemidesmosome attachment, preventing axon degeneration.
The contraction of cardiac and skeletal muscles is regulated by Ca2+ released from the sarcoplasmic reticulum in muscle cells. Here the authors provide molecular insights into Ca2+ regulation of muscle contraction by determining the cryo-EM structures of the human cardiac muscle thin filament in the absence and presence of Ca2+.
Here, Li et al. perform a genome-wide CRISPR screen to identify host dependency factors for influenza A virus infection and show that the host mRNA cap methyltransferase CMTR1 is important for viral cap snatching and that it affects expression of antiviral genes.
Data-independent acquisition (DIA) is an emerging technology in proteomics but it typically relies on spectral libraries built by data-dependent acquisition (DDA). Here, the authors use deep learning to generate in silico spectral libraries directly from protein sequences that enable more comprehensive DIA experiments than DDA-based libraries.
Various types of plasma waves are generated around electron diffusion regions (EDRs). Here the authors show electron Bernstein waves (EBWs), at the electron-scale boundary of the Hall current reversal near EDR, are sufficiently strong to diffuse electrons and modify electron pressure tensor.
Multi-view SPIM imaging can improve coverage of large samples such as whole embryos, but the procedure increases phototoxicity and involves manual steps that can introduce inconsistencies. Here the authors develop a smart rotation workflow that performs on-the-fly image analysis and identifies optimal set of views to maximize sample coverage.
High redshift blazars are efficient probes of supermassive black holes and their environment in the early Universe. Here the authors show measurements of polarised emission and proper motion in the blazar J0906+6930 (redshift of 5.47) characterised by a nascent jet embedded in and interacting with a dense medium.
How the translation speed of tropical cyclones has changed in recent decades and will change in the future has been the subject of debate. Model results show that on average, they have not slowed down in the past, but despite a slowing of tropical cyclones at higher latitudes, a poleward shift in their mean track location causes a general speed up under high greenhouse gas emissions.