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Microswimmers are promising candidates for various biomedical applications. Inspired by spermatozoa, Tan et al. report a one-step strategy to fabricate biodegradable sperm-like magnetic microswimmers with both propelling and cargo delivery functions in a vortex turbulence assisted microfluidic chip.
Ultrasound neuromodulation overcomes limitations of electrode-based stimulation through improved
targeting and long-term stability for treating neurological disorders. Here, authors present a hair-thin, implantable piezoelectric stimulator that selectively modulates neurons in the deep brain.
The overexpression of the ecotropic viral integration site-1 gene (EVI1/MECOM) marks the most lethal acute myeloid leukemia subgroup carrying 3q26 abnormalities. Here, pan-histone deacetylase inhibitors are identified as potent repressors of EVI1 and PA2G4 as a druggable target.
Biased medical artificial intelligence systems pose significant potential risks to achieving fair and equitable healthcare. Here, we demonstrate a fairer ophthalmology AI that mitigates sexism and ageism through implicit fairness learning.
This study reveals that in the alpha-proteobacterium, Caulobacter crescent, a two-tier regulation by transcriptional activation and anti-termination coordinates the synthesis of phage-like Gene Transfer Agents (GTA) particles.
The effects of different choices on preprocessing pipelines for functional connectomics remain unclear. Here, the authors systematically evaluate a multitude of pipelines on resting-state fMRI, revealing a number of optimal pipelines for functional brain network analysis.
Fractured long bones regenerate through osteo-angiogenic coupling, but how calvarial bone healing occurs is not yet clear. Here they show that regenerating blood vessels separate from co-migrating progenitors in calvarial bones, resulting in osteoblasts mineralizing a previously vascularized lesion.
Sulfenamides are a class of divalent sulfur-derived scaffolds featuring an S-N bond with many industrial applications, however, they are also challenging substrates for synthetic transformations. Here, the authors present a highly chemoselective ligand-controlled Chan–Lam coupling of sulfenamides as a straightforward route to N-arylated sulfenamides.
Semaglutide is used for glucose control and weight reduction. Here, the authors show that it enhances myocardial metabolism by targeting Creb5/NR4a1, protecting against cardiac remodeling and offering a therapeutic approach for heart failure through metabolic regulation.
The selective degradation of mitochondria by autophagy is essential for cell homeostasis. Here, Nan et al show that the effector protein BipD, secreted by Burkholderia pseudomallei, is able to modulate host mitophagy to promote its survival.
The ordering of superstructures plays a critical role in mitigating transition metal migration, voltage decay, and maintaining redox symmetry in Li-rich layered oxides. Here, this study reveals that even in the absence of such superstructure ordering, cathodes can still attain these crucial characteristics.
Non-alcoholic steatohepatitis has with few well-defined biomarkers or clinically effective treatments but is promoted by inflammation. Here, the authors find an active lipid [So(d18:1)] that is significantly changed in patients and promotes inflammation by directly inhibiting macrophage HIF-2α.
This study illustrates an asymmetric magmatic plumbing system beneath Axial Seamong along Juan de Fuca ridge. The work provides insights into the magma pathways that fed recent eruptions.
The authors report a molecular ferroelectric (TMCM)[FeCl4], which shows strong magnetostrictive and magnetoelectric effects at room temperature. The spin-lattice coupling of FeCl4 and flexible structure of organic cations are responsible for these effects.
Bioadhesive materials and patches are promising alternatives to surgical sutures and staples but many existing bioadhesives do not meet the functional requirements of current surgical procedures. Here the authors present a tissue adhesive, stretchable and rapid photo-projection compatible translational patch material which is able to deliver therapeutics.
Developing high-performance electrodes for catalyzing brine oxidation is essential for cost effective hydrogen production. Here, this study reveals the self-protective mechanism of CoFeAl layered double hydroxides, enabling stable operation in the presence of concentrated seawater at 2 A cm−2.
Nanobodies are normally made from immunized camelids, Ig transgenic mice or synthetic libraries. In this study, the authors introduce the llama Ig heavy chain locus into mice lacking this locus, thereby generating a line in which nanobodies can be made by direct immunization in the absence of an endogenous antibody repertoire.