Browse Articles

Grover’s algorithm provides a quantum speedup when searching through an unsorted database. Here, the authors perform it on 3 qubits using trapped ions, demonstrating two methods for marking the correct result in the algorithm’s oracle and providing data for searches yielding 1 or 2 solutions.

Diffusive light propagation represents a valuable additional tool for integrated photonic technologies. As an example, here the authors experimentally demonstrate optical equalisation of coherent light propagating in a femtosecond laser written circuit which simulates a dissipatively-coupled quantum chain.

The local broken symmetry induced spin-splitting in centrosymmetric materials has been predicted previously. Here the authors provide spectroscopic evidence for the coexistence of Rashba-like and Dresselhaus-like spin textures in centrosymmetric electron doped superconductor La(O,F)BiS₂.

Despite their versatility, superconducting qubits such as transmons still have limited coherence times compared to resonators. Here, the authors show how to use a single transmon to implement universal one-qubit and two-qubit operations among nine qubits encoded in superconducting resonators’ eigenmodes.

The treatment of multiple myeloma is challenging due to high relapse rates. Here the authors show that expression of ADAR1 correlates with poor patient outcomes, and that ADAR1-mediated editing of GLI1 is a mechanism relevant in the context of multiple myeloma progression and drug resistance.

Lysosomal integral membrane protein-2 (LIMP-2) is a glucocerebrosidase receptor, which is linked to kidney failure and other diseases. Here the authors show that LIMP-2 is also a phospholipid receptor and present the lipid-bound structure of the LIMP-2 luminal domain dimer and discuss its lipid trafficking mechanism.

Patients with diabetic nephropathy suffer from impaired albumin reabsorption by proximal tubular epithelial cells. Here authors use diabetic and transgenic mouse models and in vitro models to show the cause for this lies in the down regulation and internalization of the ion channels, ORAI1-3.

Cytokinesis relies on central spindle organization and provides a spatial landmark for lumen formation. Here, the authors show that intraflagellar transport proteins are required for the localization of the cytokinetic regulator Aurora B and subsequent cleavage furrow ingression and lumen positioning.

Stimulus category, saliency and value all affect the subjective value estimates that guide our decisions. Here, the authors systematically vary their stimuli along these three dimensions in humans and report category independent encoding of values and saliency in the vmPFC and striatum.

The rheological behaviour of magma in shallow conditions may help determine a volcano’s eruptive style. Here, the authors perform deformation experiments on lava from Volcán de Colima to demonstrate that crystal plasticity may preclude failure at certain shallow magmatic conditions.

Eukaryotic organisms are continuously exposed to bacteriophages, but these are not thought to enter non-phagocytic cells. Here, Lehti et al. show that a bacteriophage can bind to a specific receptor on the surface of human neuroblastoma cells in vitro, and be internalized via the endolysosomal route.

Metal-carbon σ bonds mark the basis of organometallic chemistry, but the formation of multiple such bonds between single organic and metal entities remains a challenge. Here, the authors report a one-pot aromaticity-driven method to construct osmium-based multidentate complexes containing three metal-carbon σ bonds from multiyn chains.

Dendrogenin A, cholesterol metabolite, has tumor suppressive properties but the mechanisms are unknown. Here the authors show that Dendrogenin A can induce autophagy-mediated cell death in both melanoma and acute myeloid leukaemia.

Control over the crystallographic orientation of solder joints based on βSn will improve the reliability of electronic interconnects. Using a technique based on droplet solidification and lattice matching, Ma et al. are able to control the βSn nucleation events, hence control the grain orientation.

Interleukin-13 receptor alpha 2 is highly expressed in glioblastoma multiforme but its role in this malignancy is unclear. Here the authors show that this receptor interacts with mutant EGFR, stimulating its kinase activity, thus inducing proliferation.

Plant phytochromes mediate the degradation of PIF transcription factors to transduce light signaling. Here, contrary to previous models, Qiu et al. show that degradation of PIF3 does not require the N-terminal photosensory module of PHYB but can instead be mediated by the C-terminal output module.

Cockayne syndrome group B protein (CSB) is a multifunctional chromatin remodeler involved in double-strand break repair. Here the authors investigate the molecular post-translational signals regulating CSB activity.

Transcript cleavage factors such as eukaryotic TFIIS assist the resumption of transcription following RNA pol II backtracking. Here the authors find that one of the Sulfolobus solfataricus TFIIS homolog—TFS4—has evolved into a potent RNA polymerase inhibitor potentially involved in antiviral defense.

Gut-homing and colonization of T cells are important for maintaining local immune homoeostasis and protective immunity. Here the authors show that the kinase activity of TRPM7 regulates Th17 differentiation and T cell alloreactivity in the gut by modulating SMAD2 activation and CD103 expression in T cells

Growth of large area and defect-free two-dimensional semiconductor layers for high-performance p–n junction applications has been a great challenge. Yang et al. prepare millimeter-scaled WSe₂/SnS₂ vertical heterojunctions by two-step van der Waals epitaxy, which show excellent optoelectronic properties.