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Aqueous zinc batteries are currently being explored as potential alternatives to non-aqueous lithium-ion batteries. In this comment, the authors highlight zinc’s global supply chain resilience and lower material costs yet caution about its higher mass requirement for comparable charge storage.
The direct alkenylation with simple alkenes stands out as the most ideal yet challenging strategy for obtaining high-valued desaturated alkanes. Herein, the authors present a direct asymmetric dehydrogenative α-C(sp3)-H alkenylation of carbonyls based on synergistic photoredox-cobalt-chiral primary amine catalysis under visible light.
While gene expression analysis is commonly performed, 3′UTR length analysis is limited due to technical challenges. Here the authors provide an open-access analysis pipeline for scRNA-seq data to simultaneously quantify gene expression and 3′UTR length.
Benchmarking GRN inference methods remains a challenge. Here, authors present GRouNdGAN, a causal generative model that imposes a user-defined GRN in its architecture to simulate realistic single-cell data, bridging the gap between synthetic and biological data benchmarks of GRN inference methods.
Antiferromagnetic spintronics offer high speed operations, and reduced issues with stray fields compared to ferromagnetic systems, however, antiferromagnets are typically more challenging to manipulate electrically. Here, Yang, Kim, and coauthors demonstrate electrical control of magnon dispersion and frequency in an α-Fe2O3/Pt heterostructure.
Cellular senescence and the process of transcription are intimately linked, yet the mechanisms involved remain unclear. Here the authors show that a defect in TFIIS leads to telomere dysfunction, genome instability and the release of vesicles that induce senescence to neighboring cells.
Vesicle transport ensures cargo delivery to cellular targets. Here, Soltani et al. show that Drosophila Evi5, a multiple sclerosis risk gene in humans, controls vesicular transport of iron-bound transferrins and physically interacts with ferritin.
Dynamins are required at nascent endosomes to promote membrane fission. Here, the authors use super-resolution microscopy to show that dynamin-1 recruitment relies on pre-existing nanoclusters and trapping of molecules laterally diffusing on the plasma membrane.
The expansion of the genetic code with synthetic nucleotides has broadened our ability to evolve DNA as a functional material, but we lack analytical tools for the expanded alphabet. Here the authors demonstrate an enzyme-assisted method for the sequencing of six-letter DNA.
Severe pediatric malaria remains a concern in many countries. Here, the authors use an individual-based modeling approach to evaluate the relationship between malaria prevalence and incidence of malaria pediatric hospitalizations, and show how unsteady transmission patterns affect hospitalization rates.
Intestinal homeostasis is maintained by interactions between the gut-associated lymphoid tissue and the resident flora. Here Montorsi et al use multiplexed single cell omics to describe double negative type 2 B cells and DNASE1L3-expressing dendritic cells that interact and associate with microbiota on the human gut antigenic front line.
Here, Qi et al. assembled ~3000 archaeal genomes from hot springs, capturing temporal dynamics and environmental diversity, and systematically explored functional niches and metabolic handoffs, shedding light on Archaea’s role in biogeochemical cycling.
Deep mutational scanning experiments on an S2 region spanning the fusion peptide of authentic SARS-CoV-2 with different cell lines revealed that mutations at residue 813 of the spike protein reduced TMPRSS2-mediated entry with decreased virulence.
The authors analyze the frequency, duration and intensity of stratospheric intrusions to the surface in China over 2015-2022 and find that such intrusions enhance surface ozone pollution, especially in spring and autumn, followed by summer.
PXR is a receptor activated by diverse compounds that triggers detoxification pathways in the cell, and blocking this receptor may increase the effectiveness of certain drugs. Here, the authors present the structural basis of PXR inhibition.
Visualising the structure of museum objects is a crucial step in understanding the origin, state, and composition of cultural heritage artifacts. Here the authors present an approach for creating computed tomography reconstructions using only standard 2D radiography equipment already available in most larger museums.
Simultaneous profiling of multiple RNA modifications is a promising yet understudied field of research. Here, authors develop a transferable deep learning framework capable of detecting multiple types of RNA modifications in single nanopore sequencing sample.
Traders of financial options bet that firms’ stock prices will be affected by forecasts of seasonal climate produced by the U.S. National Oceanic and Atmospheric Administration. Firms are exposed throughout the economy, and traders spend more to hedge the news from more skillful forecasts
The authors use femtosecond K-edge X-ray absorption spectroscopy to follow nuclear motion in a manganese-based tri-nuclear single-molecule magnet, and resolve changes in bond lengths on the order of hundreds of ångströms and on sub-picosecond timescales.
Anaplastic thyroid cancer (ATC) is a particularly aggressive cancer type with limited effective therapeutic options. Here, the authors identify the SUMO E3 ligase PIAS2 as a potential therapeutic target in ATC and mechanistically investigate its role in mitotic spindle and centrosome assembly.