Nanometer thin membranes filtering boron and phosphorus from water

Microporous organic nanotube assisted design of high performance nanofiltration membranes

Based on the design of natural, porous organic nanotubes, Shuangqiao Han et al. fabricate 15 nm thin membranes that can be used for water purification, specifically to filter out boron and phosporus. 

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  • Most NIR radiation absorbers used in multi jet fusion 3D printing have an intrinsic dark color which prevents printing parts with variable colors. Here, the authors design an activating fusing agent containing a strong NIR absorbing dye that turns colorless after harvesting irradiation energy during the 3D printing process and provide a bright colored part when working with other color agents.

    • Adekunle Olubummo
    • Lihua Zhao
    • Kyle Wycoff
    Article Open Access
  • Recent studies have reported the growth of 2D non-centrosymmetric single crystals on substrates with surface steps, but the mechanisms are still unclear. Here, the authors demonstrate a method to grow unidirectionally aligned transition metal dichalcogenide grains on various types of substrates, showing the importance of the simultaneous formation of grain nuclei and substrate steps.

    • Peiming Zheng
    • Wenya Wei
    • Xiaozhi Xu
    Article Open Access
  • Animals precisely control the morphology and assembly of guanine crystals to produce diverse optical phenomena but little is known about how organisms regulate crystallization to produce optically useful morphologies. Here, the authors demonstrate that pre-assembled, fibrillar sheets in developing scallop eyes template nucleation and direct the growth and orientation of plate-like guanine crystals showing a striking resemblance to melanosome morphogenesis.

    • Avital Wagner
    • Alexander Upcher
    • Benjamin A. Palmer
    Article Open Access
  • The paper presents a method that allows scaling machine learning interatomic potentials to extremely large systems, while at the same time retaining the remarkable accuracy and learning efficiency of deep equivariant models. This is obtained with an E(3)- equivariant neural network architecture that combines the high accuracy of equivariant neural networks with the scalability of local methods.

    • Albert Musaelian
    • Simon Batzner
    • Boris Kozinsky
    Article Open Access

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  • Morphogenetic shape changes are regulated by mechanical properties of interacting tissues, but other factors remain less studied. By exploring how homeotic genes regulate morphogenesis, Villedieu et al. uncover how the interplay between genetic patterning and initial tissue geometry drives morphogenesis during development.

    • Aurélien Villedieu
    • Lale Alpar
    • Yohanns Bellaïche
    Article Open Access
  • Myelodysplastic syndromes are characterised by clonal haematopoiesis, with the affected cells often harbouring mutations in the TET2 gene, an important regulator of DNA methylation state. Here authors show that the same mutations are also found in NK cells, perturbing their DNA methylation pattern and cytolytic function.

    • Maxime Boy
    • Valeria Bisio
    • Nicolas Dulphy
    Article Open Access
  • Alternative polyadenylation (APA) contributes to the post-transcriptional regulation of most human genes, yet the effects of APA are largely overlooked by conventional transcriptome-wide association studies (TWAS). Here, the authors conduct an APA-TWAS for 11 brain disorders, identifying hundreds of APA-linked disease susceptibility genes.

    • Ya Cui
    • Frederick J. Arnold
    • Wei Li
    Article Open Access
  • Cell type deconvolution in tumor spatial transcriptomics (ST) data remains challenging. Here, the authors develop Spatial Cellular Estimator for Tumors (SpaCET) to infer cell types and intercellular interactions from ST data in cancer across different platforms, with improved performance over similar methods.

    • Beibei Ru
    • Jinlin Huang
    • Peng Jiang
    Article Open Access

Subjects within Biological sciences

  • The efficacy of T-cell-based cancer immunotherapies can be compromised by T cell exhaustion. Here the authors develop a human ex vivo exhaustion model and, based on a CRISPR-Cas9 screen, identify SNX9 as a regulator of T cell exhaustion, showing that SNX9 knockout is associated with improved T cell function and anti-tumor activity in preclinical cancer models.

    • Marcel P. Trefny
    • Nicole Kirchhammer
    • Alfred Zippelius
    Article Open Access
  • The currently available transgenic T cell receptor (TCR) models represent high affinity antigen-TCR interactions. Authors here present an alternative approach to target an exogenous TCR into the physiological Trac locus in the germline of mice, which uncovers that the natural genomic context for TCRs can enhance the antigen sensitivity of lower affinity TCRs and enables the physiologic range of antigen-TCR interaction and a gene dosage dependent mechanism of central tolerance.

    • Meagan R. Rollins
    • Jackson F. Raynor
    • Ingunn M. Stromnes
    Article Open Access
  • Many genetic factors that contribute to uterine leiomyomata (UL) - the most common tumours of the female genital tract - remain to be discovered. Here, the authors conduct a UL meta-genome-wide association study, and find loci related to altered muscle tissue biology that are associated with UL.

    • Eeva Sliz
    • Jaakko S. Tyrmi
    • Johannes Kettunen
    Article Open Access

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Subjects within Scientific community and society

  • Every area of science can contribute to the changes that are required for a sustainable future through the application of its fundamental discoveries. While some fields have clear paths to application, Nature Communications believes that there is great potential for utility and application to be found in, and across, all of  the different disciplines that we publish.

    Editorial Open Access
  • Prostate cancer is a highly heterogeneous disease. Progression on androgen deprivation therapy (ADT) to castration-resistant (CRPC), or neuroendocrine prostate cancer (NEPC), is associated with poor patient survival. This comment highlights recent evidence on the epigenetic mechanisms underlying the emergence of lineage plasticity and neuroendocrine differentiation in treatment-resistant prostate tumors.

    • Goutam Chakraborty
    • Kasmira Gupta
    • Natasha Kyprianou
    Comment Open Access
  • Two new studies exploring PROTAC-mediated degradation of SMARCA2 for cancer therapy solve an apparently intractable selectivity challenge with SMARCA4 by utilising the requirement for a productive ternary complex between the protein, PROTAC and ligase complex.

    • John D. Harling
    • Christopher P. Tinworth
    Comment Open Access
  • Chalcogenide aerogels are receiving widespread attention due to their unique properties. Here we comment on a recent work about amorphous Na–Mn–Sn–S chalcogels featuring local structural control, and provide an outlook for the development of chalcogels and the metal-organic sulfide framework.

    • Lijun Yang
    • Jian Liu
    Comment Open Access
  • The development of photocatalysts is greatly hindered by false positives or non-reproducible data. Here, The authors describe the current known causes of non-reproducible results in the literature and present solutions to mitigate these false positive results.

    • Po-Wei Huang
    • Marta C. Hatzell
    Comment Open Access
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Catalysis

This page provides a snapshot of some of the most exciting work published in the broad areas of catalysis, including catalyst synthesis, catalytic characterization, mechanism, computational and theoretical catalysis, electrocatalysis, photocatalysis, environmental catalysis, asymmetric catalysis, organocatalysis, and enzymatic catalysis.
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