Peter Boone, Lauren Rochelle et al.

A rainbow mouse model for visualizing clonal expansion of oncogenes in the intestine

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Physical sciences

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  • Article
    | Open Access

    Incorporation of supramolecular macrocycles into porous organic polymers can increase uptake of guest molecules through host−guest interactions. Here the authors report a pillar[5]quinone derived multi-microporous organic polymer, which show a superior performance in radioactive iodomethane capture and storage.

    • Kecheng Jie
    • , Yujuan Zhou
    • , Qi Sun
    • , Bo Li
    • , Run Zhao
    • , De-en Jiang
    • , Wei Guo
    • , Hao Chen
    • , Zhenzhen Yang
    • , Feihe Huang
    •  & Sheng Dai
  • Article
    | Open Access

    Palm oil biofuels are touted as a sustainable alternative to fossil fuels. Meijide and colleagues use greenhouse gas measurements to update life cycle assessments of oil palm growth scenarios and show that despite the promise, emission savings do not meet sustainability standards.

    • Ana Meijide
    • , Cristina de la Rua
    • , Thomas Guillaume
    • , Alexander Röll
    • , Evelyn Hassler
    • , Christian Stiegler
    • , Aiyen Tjoa
    • , Tania June
    • , Marife D. Corre
    • , Edzo Veldkamp
    •  & Alexander Knohl
  • Article
    | Open Access

    Aspergillus fungi classified within the section Flavi include harmful and beneficial species. Here, Kjærbølling et al. analyse the genomes of 23 Flavi species, showing high genetic diversity and potential for synthesis of over 13,700 CAZymes and 1600 secondary metabolites.

    • Inge Kjærbølling
    • , Tammi Vesth
    • , Jens C. Frisvad
    • , Jane L. Nybo
    • , Sebastian Theobald
    • , Sara Kildgaard
    • , Thomas Isbrandt Petersen
    • , Alan Kuo
    • , Atsushi Sato
    • , Ellen K. Lyhne
    • , Martin E. Kogle
    • , Ad Wiebenga
    • , Roland S. Kun
    • , Ronnie J. M. Lubbers
    • , Miia R. Mäkelä
    • , Kerrie Barry
    • , Mansi Chovatia
    • , Alicia Clum
    • , Chris Daum
    • , Sajeet Haridas
    • , Guifen He
    • , Kurt LaButti
    • , Anna Lipzen
    • , Stephen Mondo
    • , Jasmyn Pangilinan
    • , Robert Riley
    • , Asaf Salamov
    • , Blake A. Simmons
    • , Jon K. Magnuson
    • , Bernard Henrissat
    • , Uffe H. Mortensen
    • , Thomas O. Larsen
    • , Ronald P. de Vries
    • , Igor V. Grigoriev
    • , Masayuki Machida
    • , Scott E. Baker
    •  & Mikael R. Andersen

Earth and environmental sciences

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  • Article
    | Open Access

    Palm oil biofuels are touted as a sustainable alternative to fossil fuels. Meijide and colleagues use greenhouse gas measurements to update life cycle assessments of oil palm growth scenarios and show that despite the promise, emission savings do not meet sustainability standards.

    • Ana Meijide
    • , Cristina de la Rua
    • , Thomas Guillaume
    • , Alexander Röll
    • , Evelyn Hassler
    • , Christian Stiegler
    • , Aiyen Tjoa
    • , Tania June
    • , Marife D. Corre
    • , Edzo Veldkamp
    •  & Alexander Knohl
  • Article
    | Open Access

    Land cover change contributes to regional climate trends. Here, the authors use high-resolution land cover maps and state-of-the-art climate modelling to assess land cover change effects across Europe over 1992-2015, showing widespread cooling after agricultural abandonment but also different, region-specific effects.

    • Bo Huang
    • , Xiangping Hu
    • , Geir-Arne Fuglstad
    • , Xu Zhou
    • , Wenwu Zhao
    •  & Francesco Cherubini
  • Article
    | Open Access

    Supported metal single-atom catalysts face challenges on both durability and practicality. Here, the authors demonstrate that a sustained 90% diesel oxidation conversion at ~160 oC is achieved by single-atom Pt on TiO2 nanowire-array integrated catalytic converter.

    • Son Hoang
    • , Yanbing Guo
    • , Andrew J. Binder
    • , Wenxiang Tang
    • , Sibo Wang
    • , Jingyue (Jimmy) Liu
    • , Tran D. Huan
    • , Xingxu Lu
    • , Yu Wang
    • , Yong Ding
    • , Eleni A. Kyriakidou
    • , Ji Yang
    • , Todd J. Toops
    • , Thomas J. Pauly
    • , Rampi Ramprasad
    •  & Pu-Xian Gao

Biological sciences

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  • Article
    | Open Access

    Structural and molecular elucidation of cerebrovascular network is promising for understanding energy supply system in the brain. Here, the authors describe labeling and tissue clearing techniques that visualize the whole-brain vasculature in a molecularly characterizable manner.

    • Takeyuki Miyawaki
    • , Shota Morikawa
    • , Etsuo A. Susaki
    • , Ai Nakashima
    • , Haruki Takeuchi
    • , Shun Yamaguchi
    • , Hiroki R. Ueda
    •  & Yuji Ikegaya
  • Article
    | Open Access

    Interaural timing and level differences had been considered the two important cues for horizontal sound localization. Here, the authors show that the third cue, spectral information, plays an essential role in the encoding of the azimuthal auditory map in the mouse superior colliculus.

    • Shinya Ito
    • , Yufei Si
    • , David A. Feldheim
    •  & Alan M. Litke
  • Article
    | Open Access

    Gram-negative bacteria deliver effectors via the type VI secretion system (T6SS) to outcompete their rivals. Here, Fridman et al. present an approach to identify T6SS effectors encoded in bacterial genomes without prior knowledge of their domain content or genetic neighbourhood, and identify a new family of membrane-disrupting effectors.

    • Chaya M. Fridman
    • , Kinga Keppel
    • , Motti Gerlic
    • , Eran Bosis
    •  & Dor Salomon

Health sciences

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  • Article
    | Open Access

    In vivo reprogramming of reactive glia using transfection of a single transcription factor has been described before by these authors and applied to models of neurodegeneration. Here the authors use this procedure in the R6/2 mouse model of Huntington’s disease, targeting astrocytes in the striatum, converting them to GABAergic neurons.

    • Zheng Wu
    • , Matthew Parry
    • , Xiao-Yi Hou
    • , Min-Hui Liu
    • , Hui Wang
    • , Rachel Cain
    • , Zi-Fei Pei
    • , Yu-Chen Chen
    • , Zi-Yuan Guo
    • , Sambangi Abhijeet
    •  & Gong Chen
  • Article
    | Open Access

    Food allergy is triggered by IgE, but some individuals are not allergic to peanuts despite making peanut-specific IgE, and are considered peanut-tolerant. Here, the authors identify differences in blood immune cell composition of peanut-allergic and tolerant infants using mass cytometry, which may help uncover the mechanism of allergic tolerance.

    • Melanie R. Neeland
    • , Sandra Andorf
    • , Monali Manohar
    • , Diane Dunham
    • , Shu-Chen Lyu
    • , Thanh D. Dang
    • , Rachel L. Peters
    • , Kirsten P. Perrett
    • , Mimi L. K. Tang
    • , Richard Saffery
    • , Jennifer J. Koplin
    •  & Kari C. Nadeau
  • Article
    | Open Access

    Changes in the pulmonary membrane, caused by bacterial infection, form part of the pathology of pneumonia. Here, the authors report on a graphene-based oxygen sensor which is used along with X-ray diffraction and AFM to measure the structural changes and changes in oxygen permeability of pulmonary membranes associated with bacterial pneumonia.

    • Mijung Kim
    • , Marilyn Porras-Gomez
    •  & Cecilia Leal

News & Comment

  • Comment
    | Open Access

    While electrosynthesis represents a green and advantageous alternative to traditional synthetic methods, electrochemical reactions still suffer from some drawbacks that require further efforts in order to fully express the potential of electricity-driven transformations. In this Comment, we will briefly discuss both the advantages and limitations of electrosynthesis, especially when compared with the other traditional synthetic organic methods, and share some forward-looking thoughts on the future developments of electrochemical reactions.

    • Yong Yuan
    •  & Aiwen Lei
  • Comment
    | Open Access

    Skyrmions in chiral magnets are a particle-like texture that has been attracting growing interest due to their novel dynamics and possible applications. Here, we discuss the role of disorder and skyrmion-skyrmion interaction in governing their motion under an external drive.

    • C. Reichhardt
    •  & C. J. O. Reichhardt
  • Comment
    | Open Access

    A pharmaceutical industry viewpoint on how the fundamental laws of photochemistry are used to identify the parameters required to implement photochemistry from lab to scale. Parameters such as photon stoichiometry and light intensity are highlighted within to inform future publications.

    • Holly E. Bonfield
    • , Thomas Knauber
    • , François Lévesque
    • , Eric G. Moschetta
    • , Flavien Susanne
    •  & Lee J. Edwards
  • Comment
    | Open Access

    Can organic chemistry mimic nature in efficiency and sustainability? Not yet, but recent developments in photoredox catalysis animated the synthetic chemistry field, providing greener opportunities for industry and academia.

    • Giacomo E. M. Crisenza
    •  & Paolo Melchiorre
  • Comment
    | Open Access

    Understanding the cellular adaptation to oxygen deficiency -hypoxia- has a profound impact on our knowledge of the pathogenesis of several diseases. The elucidation of the molecular machinery that regulates response to hypoxia has been awarded the Nobel Prize in Physiology or Medicine.

    • José López-Barneo
    •  & M. Celeste Simon
  • Comment
    | Open Access

    Two complementary studies in Nature Communications define a critical role for the anti-apoptotic protein MCL-1 as a driver of adaptive survival in tumor cells treated with oncogene targeted therapies, providing a rationale for combining these agents with newly developed MCL-1 inhibitors in the clinic.

    • Kris C. Wood

Focus

Organic Chemistry and Chemical Biology

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Organic Chemistry and Chemical Biology

Editors' Highlights: Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

Giovanni Bottari, Julia Eckhoff, Johannes Kreutzer and Prabhjot Saini

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