Jiří Pospíšil et al.

Bacterial nanotubes as a manifestation of cell death

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Physical sciences

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  • Article
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    Application of machine-learning approaches to exploring chemical reaction networks is challenging due to need of including open-shell reaction intermediates. Here the authors introduce a density functional theory database of closed and open-shell molecules for machine-learning predictions of reaction energies.

    • Sina Stocker
    • , Gábor Csányi
    • , Karsten Reuter
    •  & Johannes T. Margraf
  • Article
    | Open Access

    The authors fabricate and investigate the metasurface made of 2D iron-garnet subwavelength nanopillar array on a thin iron-garnet film. It exhibits high quality-factor resonances, leading to a multifold increase in light intensity modulation of the transmitted light with an advantage of P and S polarizations both sensitive to the medium magnetization.

    • Daria O. Ignatyeva
    • , Dolendra Karki
    • , Andrey A. Voronov
    • , Mikhail A. Kozhaev
    • , Denis M. Krichevsky
    • , Alexander I. Chernov
    • , Miguel Levy
    •  & Vladimir I. Belotelov

Earth and environmental sciences

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    The global supply chain and demand for export goods can lead to relocated emissions. Goods produced in China for foreign markets have lead to an increase of domestic non-methane volatile organic compounds emissions by 3.5 million tons in 2013 resulting in potentially an estimated 16,889 premature deaths annually.

    • Jiamin Ou
    • , Zhijiong Huang
    • , Zbigniew Klimont
    • , Guanglin Jia
    • , Shaohui Zhang
    • , Cheng Li
    • , Jing Meng
    • , Zhifu Mi
    • , Heran Zheng
    • , Yuli Shan
    • , Peter K. K. Louie
    • , Junyu Zheng
    •  & Dabo Guan
  • Article
    | Open Access

    Solar insolation is not equally distributed on the Earth’s surface and such imbalances influence the atmospheric circulation. Here, the authors show that latitudinal insolation gradients synchronized the hydroclimate in the Northern mid-latitudes and the African and South American Monsoons throughout the Holocene.

    • Michael Deininger
    • , Frank McDermott
    • , Francisco W. Cruz
    • , Juan Pablo Bernal
    • , Manfred Mudelsee
    • , Hubert Vonhof
    • , Christian Millo
    • , Christoph Spötl
    • , Pauline C. Treble
    • , Robyn Pickering
    •  & Denis Scholz
  • Article
    | Open Access

    Microwear patterns on teeth can be used to infer diet as different foods leave different marks. Here, Bestwick and colleagues analyse microwear from the teeth of pterosaurs—extinct flying reptiles colloquially known as “pterodactyls”—to reconstruct their dietary diversity and evolution.

    • Jordan Bestwick
    • , David M. Unwin
    • , Richard J. Butler
    •  & Mark A. Purnell

Biological sciences

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    The fork protection complex (FPC), including the proteins TIMELESS and TIPIN, stabilizes the replisome to ensure unperturbed fork progression during DNA replication. Here the authors reveal that that SDE2, a PCNA-associated protein, plays an important role in maintaining active replication and protecting stalled forks by regulating the replication fork protection complex (FPC).

    • Julie Rageul
    • , Jennifer J. Park
    • , Ping Ping Zeng
    • , Eun-A Lee
    • , Jihyeon Yang
    • , Sunyoung Hwang
    • , Natalie Lo
    • , Alexandra S. Weinheimer
    • , Orlando D. Schärer
    • , Jung-Eun Yeo
    •  & Hyungjin Kim
  • Article
    | Open Access

    Ammonia-oxidising archaea of the phylum Thaumarchaeota are important organisms in the nitrogen cycle. Using 12 new genomes, this study finds evidence that Nitrososphaerales evolution was marked by lateral gene transfer followed by gene duplication.

    • Paul O. Sheridan
    • , Sebastien Raguideau
    • , Christopher Quince
    • , Jennifer Holden
    • , Lihong Zhang
    • , William H. Gaze
    • , Jennifer Holden
    • , Andrew Mead
    • , Sebastien Raguideau
    • , Christopher Quince
    • , Andrew C. Singer
    • , Elizabeth M. H. Wellington
    • , Lihong Zhang
    • , Tom A. Williams
    •  & Cécile Gubry-Rangin
  • Article
    | Open Access

    Calcium flux must be carefully controlled during the phagocytosis of apoptotic cells (efferocytosis), although how this occurs is not fully understood. Here, the authors show that the Cereblon E3 ligase regulates Orai1 degradation and subsequently SOCE-mediated calcium influx.

    • Hyunji Moon
    • , Chanhyuk Min
    • , Gayoung Kim
    • , Deokhwan Kim
    • , Kwanhyeong Kim
    • , Sang-Ah Lee
    • , Byeongjin Moon
    • , Susumin Yang
    • , Juyeon Lee
    • , Seung-Joo Yang
    • , Steve K. Cho
    • , Gwangrog Lee
    • , Chang Sup Lee
    • , Chul-Seung Park
    •  & Daeho Park

Health sciences

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    In this study, Massachusetts Consortium for Pathogen Readiness (MassCPR) investigators assess the relationship between SARS-CoV-2 viral load and COVID-19 disease severity and report that the levels of detectable viral RNA, especially in plasma, correlates with severity of respiratory disease, inflammatory markers and predicted risk of death.

    • Jesse Fajnzylber
    • , James Regan
    • , Kendyll Coxen
    • , Heather Corry
    • , Colline Wong
    • , Alexandra Rosenthal
    • , Daniel Worrall
    • , Francoise Giguel
    • , Alicja Piechocka-Trocha
    • , Caroline Atyeo
    • , Stephanie Fischinger
    • , Andrew Chan
    • , Keith T. Flaherty
    • , Kathryn Hall
    • , Michael Dougan
    • , Edward T. Ryan
    • , Elizabeth Gillespie
    • , Rida Chishti
    • , Yijia Li
    • , Nikolaus Jilg
    • , Dusan Hanidziar
    • , Rebecca M. Baron
    • , Lindsey Baden
    • , Athe M. Tsibris
    • , Katrina A. Armstrong
    • , Daniel R. Kuritzkes
    • , Galit Alter
    • , Bruce D. Walker
    • , Xu Yu
    • , Jonathan Z. Li
    • , Betelihem A. (Betty) Abayneh
    • , Patrick Allen
    • , Diane Antille
    • , Alejandro Balazs
    • , Julia Bals
    • , Max Barbash
    • , Yannic Bartsch
    • , Julie Boucau
    • , Siobhan Boyce
    • , Joan Braley
    • , Karen Branch
    • , Katherine Broderick
    • , Julia Carney
    • , Josh Chevalier
    • , Manish C. Choudhary
    • , Navin Chowdhury
    • , Trevor Cordwell
    • , George Daley
    • , Susan Davidson
    • , Michael Desjardins
    • , Lauren Donahue
    • , David Drew
    • , Kevin Einkauf
    • , Sampson Elizabeth
    • , Ashley Elliman
    • , Behzad Etemad
    • , Jon Fallon
    • , Liz Fedirko
    • , Kelsey Finn
    • , Jeanne Flannery
    • , Pamela Forde
    • , Pilar Garcia-Broncano
    • , Elise Gettings
    • , David Golan
    • , Kirsten Goodman
    • , Amanda Griffin
    • , Sheila Grimmel
    • , Kathleen Grinke
    • , Ciputra Adijaya Hartana
    • , Meg Healy
    • , Howard Heller
    • , Deborah Henault
    • , Grace Holland
    • , Chenyang Jiang
    • , Hannah Jordan
    • , Paulina Kaplonek
    • , Elizabeth W. Karlson
    • , Marshall Karpell
    • , Chantal Kayitesi
    • , Evan C. Lam
    • , Vlasta LaValle
    • , Kristina Lefteri
    • , Xiaodong Lian
    • , Mathias Lichterfeld
    • , Daniel Lingwood
    • , Hang Liu
    • , Jinqing Liu
    • , Kell Lopez
    • , Yuting Lu
    • , Sarah Luthern
    • , Ngoc L. Ly
    • , Maureen MacGowan
    • , Karen Magispoc
    • , Jordan Marchewka
    • , Brittani Martino
    • , Roseann McNamara
    • , Ashlin Michell
    • , Ilan Millstrom
    • , Noah Miranda
    • , Christian Nambu
    • , Susan Nelson
    • , Marjorie Noone
    • , Lewis Novack
    • , Claire O’Callaghan
    • , Christine Ommerborn
    • , Matthew Osborn
    • , Lois Chris Pacheco
    • , Nicole Phan
    • , Shiv Pillai
    • , Falisha A. Porto
    • , Yelizaveta Rassadkina
    • , Alexandra Reissis
    • , Francis Ruzicka
    • , Kyra Seiger
    • , Kathleen Selleck
    • , Libera Sessa
    • , Arlene Sharpe
    • , Christianne Sharr
    • , Sally Shin
    • , Nishant Singh
    • , Sue Slaughenhaupt
    • , Kimberly Smith Sheppard
    • , Weiwei Sun
    • , Xiaoming Sun
    • , Elizabeth (Lizzie) Suschana
    • , Opeyemi Talabi
    • , Hannah Ticheli
    • , Scott T. Weiss
    • , Vivine Wilson
    •  & Alex Zhu
  • Article
    | Open Access

    In this study, Chen and colleagues present genomic sequences of 102 SARS-CoV-2 isolates collected in Beijing. They look closely at genomic variation between isolates that arose as a result of domestic and global transmission. Their data suggest that SARS-CoV-2 genomes have a high mutational tolerance, which may have potential implications for the development of vaccines.

    • Pengcheng Du
    • , Nan Ding
    • , Jiarui Li
    • , Fujie Zhang
    • , Qi Wang
    • , Zhihai Chen
    • , Chuan Song
    • , Kai Han
    • , Wen Xie
    • , Jingyuan Liu
    • , Linghang Wang
    • , Lirong Wei
    • , Shanfang Ma
    • , Mingxi Hua
    • , Fengting Yu
    • , Lin Wang
    • , Wei Wang
    • , Kang An
    • , Jianjun Chen
    • , Haizhou Liu
    • , Guiju Gao
    • , Sa Wang
    • , Yanyi Huang
    • , Angela R. Wu
    • , Jianbin Wang
    • , Di Liu
    • , Hui Zeng
    •  & Chen Chen
  • Article
    | Open Access

    Resistance to BRAF/MEK inhibitors is a major impediment to long-term survival for patients with BRAF-mutant melanomas. Here, the authors show that ABL kinases drive resistance by promoting MEK/ERK reactivation and the FDA-approved ABL kinase inhibitor nilotinib prevents and overcomes resistance.

    • Rakshamani Tripathi
    • , Zulong Liu
    • , Aditi Jain
    • , Anastasia Lyon
    • , Christina Meeks
    • , Dana Richards
    • , Jinpeng Liu
    • , Daheng He
    • , Chi Wang
    • , Marika Nespi
    • , Andrey Rymar
    • , Peng Wang
    • , Melissa Wilson
    •  & Rina Plattner

News & Comment

  • Comment
    | Open Access

    Low-temperature carbon dioxide electrolysis is an attractive process for sustainable fuel synthesis, but current systems suffer from low efficiency. In this comment, authors discuss the limitations arising from the reaction between carbon dioxide and hydroxide, highlighting the need for new research to address this fundamental problem.

    • Joshua A. Rabinowitz
    •  & Matthew W. Kanan
  • Comment
    | Open Access

    The human body supports a thriving diversity of microbes which comprise a dynamic, ancillary, functional system that synergistically develops in lock-step with physiological development of its host. The human microbiome field has transitioned from cataloging this rich diversity to dissecting molecular mechanisms by which microbiomes influence human health. Early life microbiome development trains immune function. Thus, vertically, horizontally, and environmentally acquired microbes and their metabolites have the potential to shape developmental trajectories with life-long implications for health.

    • Elze Rackaityte
    •  & Susan V. Lynch
  • Comment
    | Open Access

    Synthetic biology is among the most hyped research topics this century, and in 2010 it entered its teenage years. But rather than these being a problematic time, we’ve seen synthetic biology blossom and deliver many new technologies and landmark achievements.

    • Fankang Meng
    •  & Tom Ellis
  • Comment
    | Open Access

    Protected areas (PAs) are the most important conservation tool, yet assessing their effectiveness is remarkably challenging. We clarify the links between the many facets of PA effectiveness, from evaluating the means, to analysing the mechanisms, to directly measuring biodiversity outcomes.

    • Ana S. L. Rodrigues
    •  & Victor Cazalis
  • Comment
    | Open Access

    Myelinating Schwann cells control the diameter of the axons they ensheath by an unknown mechanism. In a recent article in Nature Communications, Eichel and colleagues identify the tetraspan protein CMTM6 as a regulator of axonal caliber.

    • Nimrod Elazar
    •  & Elior Peles
  • Comment
    | Open Access

    A large-scale screening campaign has yielded dozens of crystal structures of small molecule fragments that bind to the main protease of SARS-CoV-2. The global research community is encouraged to pursue these as drug discovery starting points for COVID-19.

    • Daniel A. Erlanson

Focus

Therapeutics

Jaeok Park et al./doi:10.1038/ncomms14132

Therapeutics

Editors' Highlights: Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

Ross Cloney, Francesco Conti, Sonja Schmid and Aishwarya Sundaram

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