DNA synthesis for true random number generation

Secure data encryption increasingly needs large volumes of true random numbers. Linda Meiser et al. use the stochastic nature of DNA synthesis to obtain millions of gigabytes of unbiased randomness.


Latest Research articles

  • Conducting atom-optical experiments in space is interesting for fundamental physics and challenging due to different environment compared to ground. Here the authors report matter-wave interferometry in space using atomic BECs in a sounding rocket.

    • Maike D. Lachmann
    • Holger Ahlers
    • Ernst M. Rasel
    Article Open Access
  • Nanofluidic channels offer the possibility to process small molecules or colloids, but transport control meets serious challenges. Seo et al. use evaporation-driven advective flow to establish a versatile manipulation scheme of the fluid carrier, disposing of external connectors.

    • Sangjin Seo
    • Dogyeong Ha
    • Taesung Kim
    Article Open Access
  • Switching mechanical properties in stiff bioinspired nanocomposites is challenging as they contain high fractions of hard reinforcements. Here, the authors demonstrate reversible electrical switching in highly-reinforced cellulose nanopapers using an applied low direct current.

    • Dejin Jiao
    • Francisco Lossada
    • Andreas Walther
    Article Open Access

Subjects within Physical sciences

  • The extent to which chemical products of water radiolysis could sustain subseafloor microbial life is unknown. Here the authors show that sediment catalyzes radiolytic production of H2 and oxidants, providing the primary energy source for life in ancient marine sediment.

    • Justine F. Sauvage
    • Ashton Flinders
    • Steven D’Hondt
    Article Open Access
  • Here, the authors identify that magnetotelluric conductive anomalies commonly observed on the trenchward-side of volcanic arcs in subduction zones can be explained by subducted sediments. High-pressure experiments show that these sediment melts will react with the overlying mantle wedge to produce electrically conductive phlogopite pyroxenites.

    • M. W. Förster
    • K. Selway
    Article Open Access
  • Generally it is thought that ash aggregation leads to reduced atmospheric travel distances. Here, the authors show that the rafting effect can increase dispersal range by up to 3.7 times for particles between 300–500 μm, compared to sedimentation of individual clasts.

    • Eduardo Rossi
    • Gholamhossein Bagheri
    • Costanza Bonadonna
    Article Open Access
  • COVID-19 might occur together with other natural disasters but frameworks to quantify collective effects is lacking. Here, the authors investigated the readiness of a healthcare system in the face of wildfire during an epidemic by assuming the COVID-19 pandemic occurred around the same time with the Camp Fire case in Butte Country California 2018/2019.

    • Emad M. Hassan
    • Hussam N. Mahmoud
    Article Open Access

Subjects within Earth and environmental sciences

  • During differentiation, chromosome conformation is remodelled to support lineage-specific transcriptional programs. Here, the authors characterise chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, and provide evidence that chromosome reconfiguration occurs prior to DNA replication and mitosis and guides gene expression that controls differentiation.

    • Wing Fuk Chan
    • Hannah D. Coughlan
    • Rhys S. Allan
    Article Open Access
  • Koalas are susceptible to neoplasms, which are related to infection with the Koala retrovirus. Here, the authors use DNA sequencing to show that the retroviral insertion sites cluster near known cancer genes and demonstrate a high mutational load associated with the germline invasion of the virus.

    • Gayle K. McEwen
    • David E. Alquezar-Planas
    • Alex D. Greenwood
    Article Open Access
  • It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of cell proliferation.

    • Chen Jiang
    • Ahsan Javed
    • Thomas Worzfeld
    Article Open Access
  • The cell source and dynamics of Notch ligands during the regulation of muscle stem cells is unclear. Here, the authors show that the Notch ligand Dll1 has to oscillate in order to control the balance between self-renewal and differentiation of muscle stem cells, with Hes1 acting as transcriptional pacemaker for the oscillatory network.

    • Yao Zhang
    • Ines Lahmann
    • Carmen Birchmeier
    Article Open Access
  • The uptake of donor pluripotent stem cells (PSCs) in hosts of different species and subsequent germline transmission is very inefficient. Here, the authors show, using Prdm14 gene depleted rat host blastocysts to remove functional sperm, that germline transmission from donor rat or mouse PSCs is possible.

    • Toshihiro Kobayashi
    • Teppei Goto
    • Masumi Hirabayashi
    Article Open Access

Subjects within Biological sciences

  • COVID-19 might occur together with other natural disasters but frameworks to quantify collective effects is lacking. Here, the authors investigated the readiness of a healthcare system in the face of wildfire during an epidemic by assuming the COVID-19 pandemic occurred around the same time with the Camp Fire case in Butte Country California 2018/2019.

    • Emad M. Hassan
    • Hussam N. Mahmoud
    Article Open Access
  • Muscle atrophy is associated with ageing, but the underlying molecular mechanisms are not well understood. Here, they authors show that ablation of the E3 ubiquitin ligase Mib1 is important for myofibre maintenance via a mechanism that involves targeting and degradation of Actn3, and that Mib1 ablation in mice induces muscle atrophy which can be rescued by knockown of Actn3 expression.

    • Ji-Yun Seo
    • Jong-Seol Kang
    • Young-Yun Kong
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  • Treatments for Fabry disease, an inherited lysosomal disorder caused by the deficiency of the enzyme alpha-galactosidase A, are not fully efficacious. Here the authors report a single-arm phase I trial of gene therapy with autologous, lentivirus-transduced, hematopoietic cells that express alpha-galactosidase A to demonstrate that this approach is safe in five patients with Fabry disease.

    • Aneal Khan
    • Dwayne L. Barber
    • Jeffrey A. Medin
    Article Open Access
  • Blood circulating proteins reflect biological processes, thus providing insight into complex traits. Here the authors study the relationship between 1000 plasma proteins and body mass index (BMI), highlighting widespread proteome changes and causal relationships between BMI and specific proteins.

    • Shaza B. Zaghlool
    • Sapna Sharma
    • Karsten Suhre
    Article Open Access

Subjects within Health sciences

  • The unprecedented cost of the 2018 eruption in Hawai’i reflects an intersection of disparate physical and social phenomena: widely spaced, highly destructive eruptions, and atypically high population growth. These were linked and the former indirectly drove the latter with unavoidable consequences.

    • Bruce F. Houghton
    • Wendy A. Cockshell
    • Eric Yamashita
    Comment Open Access
  • Neural recording technologies increasingly enable simultaneous measurement of neural activity from multiple brain areas. To gain insight into distributed neural computations, a commensurate advance in experimental and analytical methods is necessary. We discuss two opportunities towards this end: the manipulation and modeling of neural population dynamics.

    • Krishna V. Shenoy
    • Jonathan C. Kao
    Comment Open Access
  • Writing in Nature communications, Zhu and collaborators reported the development of a genetically encoded sensor for the detection of formaldehyde in cells and tissues. This tool has great potential to transform formaldehyde research; illuminating a cellular metabolite that has remained elusive in live structures.

    • Carla Umansky
    • Agustín E. Morellato
    • Lucas B. Pontel
    Comment Open Access
  • Many newly-discovered microbial phyla have been studied solely by cultivation-independent techniques such as metagenomics. Much of their biology thus remains elusive, because the organisms have not yet been isolated and grown in the lab. Katayama et al. lift the curtain on some intriguing biology by cultivating and studying bacteria from the elusive OP9 phylum (Atribacterota).

    • Muriel C. F. van Teeseling
    • Christian Jogler
    Comment Open Access
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