Mechanically interlocked architectures inspired the fabrication of numerous molecular systems, but the topological design of such architectures has not been fully explored from the nano- to the macroscopic scale. Here, the authors propose a MOFaxane, comprised of long chain molecules penetrating a microcrystal of metal– organic framework.

EuIn₂As₂ is a candidate as an axion insulator, a material that can host axion-like quasi-particles, in direct analogy with the axion proposed in particle physics to resolve the so called “strong CP problem”. Here Soh et al., perform resonant elastic X-Ray scattering on EuIn₂As₂ and show that the magnetic order consists of commensurate chiral magnetic structures, satisfying the symmetry requirements for EuIn₂As₂ to be an axion insulator.’

Energy harvesting by utilizing optical control has emerged as a promising solution to alleviate energy and environmental crisis. However, it is challenging to realise nano-scale energy storage and conversion in the same material. Here the authors report a nonferroelectric molecular [CoGa] crystal that uses light as an external stimulus to exhibit photoenergy conversion and energy storage properties.

Deciphering the reaction mechanisms of CO/CO2 electroreduction to methanol remains challenging. Here the authors report the higher electron density of single-Co-atom center, along with a different adsorption configuration of *CO, is crucial for promoting the CO electroreduction to methanol.

Phonons are the collective excitations of the lattice of a material, and can, in the case of chiral phonons, carry angular momentum, allowing for strong coupling to the magnetic properties of the material. Here, Cui, Bostrom and co-authors observe chiral magnon polarons, the hybridized quasiparticles of chiral phonons and magnons, in the van der Waals antiferromagnet FePSe₃.

Tree growth in boreal forests is generally predicted to increase under warming. Here, the authors demonstrate a method to analyze physiologically informed temperature series of tree-ring data, finding potentially overlooked growth-temperature responses and projecting increasing risks of warming to boreal larch forests.

Dunes and woody-debris preserved in the rock record have been used to quantify the magnitude and duration of flow events in ancient rivers, revealing a fluvial system dominated by flashy, storm-driven floods 300 million years ago.

Boreal forests are expanding at high latitudes yet declining at their southern boundaries. Here, the authors show that such trends are not symmetrical in North America, where poleward expansion of boreal forests did not offset southern declines often linked to wildfires and logging.

Nitrogen monoxide at low concentrations can promote the formation of highly oxygenated organic molecules, which are crucial precursors to secondary organic aerosol (SOA), rather than inhibit it as traditionally thought.

“Factors influencing soil microbiota functioning remain understudied. Here, the authors describe bacterial and fungal diversity across Europe and along a gradient of land-use perturbation, observing that the occurrence of pathogens, symbionts and saprotrophs varied among cropland, woodland and grassland.”

While dimethylarginine dimethylaminohydrolase 1 (DDAH1) is known to metabolize the endogenous inhibitor of nitric oxide synthases, asymmetric dimethylarginine (ADMA), the function of DDAH2 has remained controversial. Here, the authors present several lines of evidence that DDAH2 does not hydrolyze ADMA.

Molecular mechanisms of MFSD2A-mediated lysolipid transport into the brain has been elusive. Here, using molecular dynamics, the authors uncover how initial stages of transport cycle are enabled by substrate-induced conformational changes in MFSD2A.

The authors present a workflow integrating metabolic perturbations with protein structural analysis to identify drug off-targets, demonstrating how combining machine learning methods with mechanistic analyses can benefit off-target identification.

Village cultures, where multiple stem cell lines are cultured in a single dish, provide an elegant solution for population-scale studies. Here, authors show the utility of village models – showing that expression heterogeneity is largely a result of line-specific effects and not village cultures.

Imc is a midbrain inhibitory nucleus essential for stimulus selection across space. Here, the authors show in the barn owl that global inhibitory surrounds of Imc neurons are constructed within Imc, but their classical inhibitory surrounds are inherited from inputs.

Current liquid-based optical clearing protocols can suffer from solvent evaporation and photobleaching. Here, the authors develop a solid high-refractive-index polymer to embed mouse and human tissues for clearing and antifade high-resolution 3D imaging.

The molecular mechanisms underlying androgen production in prostate cancer remain to be explored. Here, the authors reveal an epigenetic mark, K130Ac on H2A, following dual-phosphorylation on SREBP1 promoting de novo androgen synthesis to overcome the pharmacological inhibition of androgen synthesis.

Here the authors develop viP-CLIP, a technique allowing the identification of RNA binding proteins (RBP) targets in mouse tissues, and identify the RBP Tial1 as a regulator of cholesterol metabolism in the liver.

BRCA1/2 mutations are known to increase risk of breast and ovarian cancer but carrier status in healthy individuals is unknown without genetic testing. Here, the authors created a circulating miRNA signature to predict BRCA1/2 carrier status in healthy individuals to aid the decision process on genetic testing.

The increase in detoxification gene expression is a common transcriptome marker for longevity interventions. Here, the authors show that nomilin extends lifespan and healthspan in animals through activation of PXR regulated detoxification functions.

Using two different mass spectrometric platforms, authors demonstrate how metabolomic data fusion and multivariate analysis can be used to accurately identify the geographic origin and production method of salmon.

Global COVID-19 vaccine distribution has been inequitable. In this mathematical modelling study, the authors estimate the proportion of deaths that could have been averted in twenty low- and lower-middle-income countries if vaccines had been more widely available early in the pandemic.

The potential for the mitigation of global non-CO₂ greenhouse gases is highly uncertain. Harmsen et al. estimate this uncertainty and show that it has large implications for the feasibility of reaching the Paris Climate Agreement targets.

The climate benefits of battery electric vehicles relative to internal combustion engine vehicles are favorable but usually delayed. The authors show the delay threshold in China and call for more attention to the temporal characteristics of climate benefits.

Humans and machines are increasingly participating in mixed collectives in which they can help or hinder each other. Here the authors show the way in which people treat machines differently than humans in a stylized society of beneficiaries, helpers, punishers, and trustors.