A lattice of protein tetramers

A self-assembling 2D lattice protects replication of a bacterial virus

Some bacterial viruses enclose their replicating DNA in a protein-based ‘phage nucleus’. Nieweglowska et al. show that the structure is a lattice of tetramers linked by flexible loops and tails.


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  • Here, the authors assess performance and limitations to polygenic risk scores in different race/ethnic groups. They find that polygenic risk score performance improves with diverse training data, and a better understanding of varying genetic backgrounds, social and environmental factors, and gene-environment interactions, is needed to enhance PRS performance for all groups.

    • Nuzulul Kurniansyah
    • Matthew O. Goodman
    • Tamar Sofer
    ArticleOpen Access
  • Patients with lung adenocarcinoma (LUAD) patients carrying EGFR mutations are often treated with EGFR-tyrosine kinase inhibitors (EGFR-TKIs), but sensitivity to the therapy varies. Here, using 3D printed patient derived xenograft models, the authors identify a NOTCH mutation as an indicator of favourable response to EGFR-TKI in LUAD.

    • Bin Zhang
    • Shaowei Dong
    • Chang Zou
    ArticleOpen Access
  • With increasing age, brown adipose tissue (BAT) becomes characterized by increased adiposity and immune cell infiltration but reduced thermogenic capacity. Here the authors report that bone marrow-derived pro-inflammatory and senescent S100A8+ immune cells accumulate in BAT of male rats and mice during aging and contribute to BAT dysfunction.

    • Xu Feng
    • Liwen Wang
    • Haiyan Zhou
    ArticleOpen Access
  • Lung cancer screening could enhance early diagnosis and treatment. Here, the authors used proteomic analysis of pre-diagnosis samples across 6 cohorts to identify 36 proteins associated with imminent lung cancer diagnosis.

    • Demetrius Albanes
    • Karine Alcala
    • Wei Zheng
    ArticleOpen Access

Subjects within Health sciences

Subjects within Scientific community and society

  • The Tara Pacific program and expedition focused on coral reefs across the Pacific Ocean and used a coordinated sampling effort to address questions at multiple scales using a common suite of samples. Here, we highlight some of the Tara Pacific achievements, discussing the benefits of long-duration sea expeditions for investigating a wide array of research questions within a selected ecosystem.

    • Serge Planes
    • Denis Allemand
    CommentOpen Access
  • The samples returned from near-Earth asteroid (162173) Ryugu provide a pristine record of the 4.6 billion years since the birth of the Solar System. The Hayabusa2 initial analysis team has integrated a range of analytical techniques to investigate Ryugu’s organic chemistry. Here, we highlight their latest findings, the potential questions which may be answered, and provide an overview of new prospects in the decade to come.

    • Yasuhiro Oba
    • Yoshinori Takano
    • Hiroshi Naraoka
    CommentOpen Access
  • Identifying topological defects in disordered materials has a profound effect on predicting when and where the material will break. Matteo Baggioli comments a recent publication in Nature Communications, which confirms the existence of defects in glasses and their crucial role for plasticity.

    • Matteo Baggioli
    CommentOpen Access
  • Early detection of immunotherapy-induced tumor response is of major benefit for patients but can be complicated by therapy-induced pseudoprogression. A consensus guideline-iRECIST- was developed as a modification of Response Evaluation Criteria in Solid Tumours (RECIST version 1.1). Here we describe which next steps are required to test its validity and how novel approaches for response criteria might be developed and included.

    • Elena Garralda
    • Scott A. Laurie
    • Elisabeth G. E. de Vries
    CommentOpen Access
  • Issues with data reuse have been recognized in synthetic biology and the broader scientific community. Policies and standards fall short as machine reasoning is not emphasised and enforcement is lacking. We discuss the progress, remaining challenges, and possible solutions.

    • Jeanet Mante
    • Chris J. Myers
    CommentOpen Access

Biotechnology and methods

Papers highlighted here represent a snapshot of some of the recent exciting work published in the area of bioengineering, genome engineering, metabolic engineering, synthetic biology, system and computational biology, cellular biotechnology and imaging, and therapeutic biotechnology.
  • Chuanfu An, Ross Cloney, Cara Eldridge, Philip Lössl, Aline Lueckgen, Doaa Megahed, Anne Mirabella and Lorenzo Righetto


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