Jiří Pospíšil et al.

Bacterial nanotubes as a manifestation of cell death

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Physical sciences

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  • Article
    | Open Access

    Interacting self-propelled particles exhibit phase separation or collective motion depending on particle shape. A unified theory connecting these paradigms represents a major challenge in active matter, which the authors address here by modeling active particles as continuum fields.

    • Robert Großmann
    • , Igor S. Aranson
    •  & Fernando Peruani
  • Article
    | Open Access

    Here, the authors explore the blue photoluminescence signal arising from the interface between graphene and h-BN arranged in in-plane heterostructures, and fabricate a blue light emitting device utilizing the heterojunction as the emitting layer.

    • Gwangwoo Kim
    • , Kyung Yeol Ma
    • , Minsu Park
    • , Minsu Kim
    • , Jonghyuk Jeon
    • , Jinouk Song
    • , José Eduardo Barrios-Vargas
    • , Yuta Sato
    • , Yung-Chang Lin
    • , Kazu Suenaga
    • , Stephan Roche
    • , Seunghyup Yoo
    • , Byeong-Hyeok Sohn
    • , Seokwoo Jeon
    •  & Hyeon Suk Shin
  • Article
    | Open Access

    Urban development has dramatically increased in recent decades. Analyzing 841 large cities throughout the world for the period from 2001 to 2018, the authors disclosed uneven features of global urbanization in terms of urban expansion, population growth, and greening at different economic levels.

    • Liqun Sun
    • , Ji Chen
    • , Qinglan Li
    •  & Dian Huang

Earth and environmental sciences

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  • Article
    | Open Access

    Urban development has dramatically increased in recent decades. Analyzing 841 large cities throughout the world for the period from 2001 to 2018, the authors disclosed uneven features of global urbanization in terms of urban expansion, population growth, and greening at different economic levels.

    • Liqun Sun
    • , Ji Chen
    • , Qinglan Li
    •  & Dian Huang
  • Article
    | Open Access

    Eutrophication has been shown to weaken diversity-stability relationships in grasslands, but it is unclear whether the effect depends on scale. Analysing a globally distributed network of grassland sites, the authors show a positive role of beta diversity and spatial asynchrony as drivers of stability but find that nitrogen enrichment weakens the diversity-stability relationships at different spatial scales.

    • Yann Hautier
    • , Pengfei Zhang
    • , Michel Loreau
    • , Kevin R. Wilcox
    • , Eric W. Seabloom
    • , Elizabeth T. Borer
    • , Jarrett E. K. Byrnes
    • , Sally E. Koerner
    • , Kimberly J. Komatsu
    • , Jonathan S. Lefcheck
    • , Andy Hector
    • , Peter B. Adler
    • , Juan Alberti
    • , Carlos A. Arnillas
    • , Jonathan D. Bakker
    • , Lars A. Brudvig
    • , Miguel N. Bugalho
    • , Marc Cadotte
    • , Maria C. Caldeira
    • , Oliver Carroll
    • , Mick Crawley
    • , Scott L. Collins
    • , Pedro Daleo
    • , Laura E. Dee
    • , Nico Eisenhauer
    • , Anu Eskelinen
    • , Philip A. Fay
    • , Benjamin Gilbert
    • , Amandine Hansar
    • , Forest Isbell
    • , Johannes M. H. Knops
    • , Andrew S. MacDougall
    • , Rebecca L. McCulley
    • , Joslin L. Moore
    • , John W. Morgan
    • , Akira S. Mori
    • , Pablo L. Peri
    • , Edwin T. Pos
    • , Sally A. Power
    • , Jodi N. Price
    • , Peter B. Reich
    • , Anita C. Risch
    • , Christiane Roscher
    • , Mahesh Sankaran
    • , Martin Schütz
    • , Melinda Smith
    • , Carly Stevens
    • , Pedro M. Tognetti
    • , Risto Virtanen
    • , Glenda M. Wardle
    • , Peter A. Wilfahrt
    •  & Shaopeng Wang
  • Article
    | Open Access

    Overflow water is an important part of the Atlantic Meridional Overturning Circulation, yet how it reaches the Greenland-Scotland Ridge is not fully known. Here, the authors show that the interior of the Greenland Sea gyre is the primary wintertime source of the densest portion of both Denmark Strait and Faroe Bank Channel overflows.

    • Jie Huang
    • , Robert S. Pickart
    • , Rui Xin Huang
    • , Peigen Lin
    • , Ailin Brakstad
    •  & Fanghua Xu

Biological sciences

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    | Open Access

    Krabbe disease is caused by GALC deficiency, leading to accumulation of cytotoxic psychosine, demyelination, and neurodegeneration. Here, the authors develop a Galc flox mouse line to model Krabbe disease and unveil that early postnatal GALC neuronal expression is critical for disease pathogenesis.

    • Nadav I. Weinstock
    • , Conlan Kreher
    • , Jacob Favret
    • , Duc Nguyen
    • , Ernesto R. Bongarzone
    • , Lawrence Wrabetz
    • , M. Laura Feltri
    •  & Daesung Shin
  • Article
    | Open Access

    In high fidelity DNA polymerases the exonuclease site is distal from the polymerization site and it is unknown how the primer strand travels between the two sites when mis-incorporated nucleotides must be removed. Here, the authors perform MD simulations and identify an optimal path for DNA primer strand translocation in the E. coli replicative DNA polymerase III and characterise the kinetics and dynamics of the Pol III pol-to-exo mode transition, which is validated with mutagenesis experiments.

    • Thomas Dodd
    • , Margherita Botto
    • , Fabian Paul
    • , Rafael Fernandez-Leiro
    • , Meindert H. Lamers
    •  & Ivaylo Ivanov
  • Article
    | Open Access

    Eutrophication has been shown to weaken diversity-stability relationships in grasslands, but it is unclear whether the effect depends on scale. Analysing a globally distributed network of grassland sites, the authors show a positive role of beta diversity and spatial asynchrony as drivers of stability but find that nitrogen enrichment weakens the diversity-stability relationships at different spatial scales.

    • Yann Hautier
    • , Pengfei Zhang
    • , Michel Loreau
    • , Kevin R. Wilcox
    • , Eric W. Seabloom
    • , Elizabeth T. Borer
    • , Jarrett E. K. Byrnes
    • , Sally E. Koerner
    • , Kimberly J. Komatsu
    • , Jonathan S. Lefcheck
    • , Andy Hector
    • , Peter B. Adler
    • , Juan Alberti
    • , Carlos A. Arnillas
    • , Jonathan D. Bakker
    • , Lars A. Brudvig
    • , Miguel N. Bugalho
    • , Marc Cadotte
    • , Maria C. Caldeira
    • , Oliver Carroll
    • , Mick Crawley
    • , Scott L. Collins
    • , Pedro Daleo
    • , Laura E. Dee
    • , Nico Eisenhauer
    • , Anu Eskelinen
    • , Philip A. Fay
    • , Benjamin Gilbert
    • , Amandine Hansar
    • , Forest Isbell
    • , Johannes M. H. Knops
    • , Andrew S. MacDougall
    • , Rebecca L. McCulley
    • , Joslin L. Moore
    • , John W. Morgan
    • , Akira S. Mori
    • , Pablo L. Peri
    • , Edwin T. Pos
    • , Sally A. Power
    • , Jodi N. Price
    • , Peter B. Reich
    • , Anita C. Risch
    • , Christiane Roscher
    • , Mahesh Sankaran
    • , Martin Schütz
    • , Melinda Smith
    • , Carly Stevens
    • , Pedro M. Tognetti
    • , Risto Virtanen
    • , Glenda M. Wardle
    • , Peter A. Wilfahrt
    •  & Shaopeng Wang

Health sciences

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  • Article
    | Open Access

    Mutations in TREM2 alter risk for Alzheimer’s disease, though the mechanisms underlying risk in human cells are unclear. Here, the authors use iPS-microglia and chimeric mice to highlight altered survival, phagocytosis, migration, and transcriptional programs in microglia lacking TREM2.

    • Amanda McQuade
    • , You Jung Kang
    • , Jonathan Hasselmann
    • , Amit Jairaman
    • , Alexandra Sotelo
    • , Morgan Coburn
    • , Sepideh Kiani Shabestari
    • , Jean Paul Chadarevian
    • , Gianna Fote
    • , Christina H. Tu
    • , Emma Danhash
    • , Jorge Silva
    • , Eric Martinez
    • , Carl Cotman
    • , G. Aleph Prieto
    • , Leslie M. Thompson
    • , Joan S. Steffan
    • , Ian Smith
    • , Hayk Davtyan
    • , Michael Cahalan
    • , Hansang Cho
    •  & Mathew Blurton-Jones
  • Article
    | Open Access

    Quantifying lipid and water content in tissues non-invasively is difficult, and no method exists to quantify lipids in blood non-invasively. Here the authors develop an imaging approach called shortwave infrared meso-patterned imaging (SWIR-MPI) to detect and spatially map tissue water and lipids in preclinical models.

    • Yanyu Zhao
    • , Anahita Pilvar
    • , Anup Tank
    • , Hannah Peterson
    • , John Jiang
    • , Jon C. Aster
    • , John Paul Dumas
    • , Mark C. Pierce
    •  & Darren Roblyer
  • Article
    | Open Access

    Prime editing uses Cas9 nickase fused to a reverse transcriptase to edit genetic information. Here, the authors prime edit primary adult stem cells in 3D organoid cultures to show functional correction of pathogenic mutations without genome-wide off-target effects.

    • Imre F. Schene
    • , Indi P. Joore
    • , Rurika Oka
    • , Michal Mokry
    • , Anke H. M. van Vugt
    • , Ruben van Boxtel
    • , Hubert P. J. van der Doef
    • , Luc J. W. van der Laan
    • , Monique M. A. Verstegen
    • , Peter M. van Hasselt
    • , Edward E. S. Nieuwenhuis
    •  & Sabine A. Fuchs

News & Comment

  • Comment
    | Open Access

    The human body supports a thriving diversity of microbes which comprise a dynamic, ancillary, functional system that synergistically develops in lock-step with physiological development of its host. The human microbiome field has transitioned from cataloging this rich diversity to dissecting molecular mechanisms by which microbiomes influence human health. Early life microbiome development trains immune function. Thus, vertically, horizontally, and environmentally acquired microbes and their metabolites have the potential to shape developmental trajectories with life-long implications for health.

    • Elze Rackaityte
    •  & Susan V. Lynch
  • Comment
    | Open Access

    Low-temperature carbon dioxide electrolysis is an attractive process for sustainable fuel synthesis, but current systems suffer from low efficiency. In this comment, authors discuss the limitations arising from the reaction between carbon dioxide and hydroxide, highlighting the need for new research to address this fundamental problem.

    • Joshua A. Rabinowitz
    •  & Matthew W. Kanan
  • Comment
    | Open Access

    Synthetic biology is among the most hyped research topics this century, and in 2010 it entered its teenage years. But rather than these being a problematic time, we’ve seen synthetic biology blossom and deliver many new technologies and landmark achievements.

    • Fankang Meng
    •  & Tom Ellis
  • Comment
    | Open Access

    Protected areas (PAs) are the most important conservation tool, yet assessing their effectiveness is remarkably challenging. We clarify the links between the many facets of PA effectiveness, from evaluating the means, to analysing the mechanisms, to directly measuring biodiversity outcomes.

    • Ana S. L. Rodrigues
    •  & Victor Cazalis
  • Comment
    | Open Access

    Myelinating Schwann cells control the diameter of the axons they ensheath by an unknown mechanism. In a recent article in Nature Communications, Eichel and colleagues identify the tetraspan protein CMTM6 as a regulator of axonal caliber.

    • Nimrod Elazar
    •  & Elior Peles
  • Q&A
    | Open Access

    Dr. Kishana Taylor (a microbiologist and Postdoctoral Researcher at the University of California, Davis), Dr. Nella Vargas-Barbosa (an electrochemist and Scientist at the Max Planck Institute) and Dr. Anouk Beniest (a geologist and Postdoctoral Researcher at GEOMAR Helmholtz Centre for Ocean Research Kiel) talked to Nature Communications about their recent experiences at virtual conferences as early career researchers, since the onset of international COVID-19 travel restrictions. Kishana, Nella and Anouk share tips for navigating virtual conferences as junior researchers, and they also give suggestions for conference organizers to improve virtual scientific meetings so they more inclusive for younger scientists.

Focus

Therapeutics

Jaeok Park et al./doi:10.1038/ncomms14132

Therapeutics

Editors' Highlights: Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

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