Alasdair H. Fikouras et al.

Non-obstructive intracellular nanolasers

Latest Research

  • Article | | open

    Sodium-dependent glucose transporters (SGLTs) transport sugars across the plasma membrane and play important roles in renal sugar reabsorption. Here authors develop structural models of human SGLT1/2 (hSGLT1/2) in complex with inhibitors which helps to understand inhibitor subtype selectivity.

    • Paola Bisignano
    • , Chiara Ghezzi
    • , Hyunil Jo
    • , Nicholas F. Polizzi
    • , Thorsten Althoff
    • , Chakrapani Kalyanaraman
    • , Rosmarie Friemann
    • , Matthew P. Jacobson
    • , Ernest M. Wright
    •  & Michael Grabe
  • Article | | open

    Integral membrane proteins are assembled into the ER membrane via the ribosome-translocon channel. Here authors use in vitro translation assays and MD simulations to show that folding in the ribosome is favorable for TM helices, but unfavorable for soluble helices.

    • Manuel Bañó-Polo
    • , Carlos Baeza-Delgado
    • , Silvia Tamborero
    • , Anthony Hazel
    • , Brayan Grau
    • , IngMarie Nilsson
    • , Paul Whitley
    • , James C. Gumbart
    • , Gunnar von Heijne
    •  & Ismael Mingarro
  • Article | | open

    Clostridium difficile causes diarrhea and colitis by producing up to three different protein toxins. Here, Tam et al. show that an anthelmintic drug, niclosamide, inhibits the pathogenesis of all three toxins by targeting a host process required for toxin entry into host cells, without disrupting the gut microbiota.

    • John Tam
    • , Therwa Hamza
    • , Bing Ma
    • , Kevin Chen
    • , Greg L. Beilhartz
    • , Jacques Ravel
    • , Hanping Feng
    •  & Roman A. Melnyk
  • Article | | open

    Reconstructions of evolutionary history from molecular vs. fossil data are often in conflict. Here, the authors show that discrepancies in speciation and extinction rates can arise from differing assumptions about underlying processes and present a model that reconciles fossil and molecular evidence.

    • Daniele Silvestro
    • , Rachel C. M. Warnock
    • , Alexandra Gavryushkina
    •  & Tanja Stadler
  • Article | | open

    The late Paleozoic was a time of major transition for tetrapods. Here, Brocklehurst and colleagues analyse the biogeography of Paleozoic tetrapods and find shifts in dispersal and vicariance associated with Carboniferous mountain formation and end-Guadalupian climate variability.

    • Neil Brocklehurst
    • , Emma M. Dunne
    • , Daniel D. Cashmore
    •  & Jӧrg Frӧbisch
  • Article | | open

    Magnetic energy in the plasma is transferred into particle energy by magnetic reconnection. Here the authors show the two-fluid dynamics of asymmetric magnetic reconnection in two different spatial scales of plasma, namely laboratory and astrophysical plasma.

    • M. Yamada
    • , L.-J. Chen
    • , J. Yoo
    • , S. Wang
    • , W. Fox
    • , J. Jara-Almonte
    • , H. Ji
    • , W. Daughton
    • , A. Le
    • , J. Burch
    • , B. Giles
    • , M. Hesse
    • , T. Moore
    •  & R. Torbert
  • Article | | open

    Sodium-dependent glucose transporters (SGLTs) transport sugars across the plasma membrane and play important roles in renal sugar reabsorption. Here authors develop structural models of human SGLT1/2 (hSGLT1/2) in complex with inhibitors which helps to understand inhibitor subtype selectivity.

    • Paola Bisignano
    • , Chiara Ghezzi
    • , Hyunil Jo
    • , Nicholas F. Polizzi
    • , Thorsten Althoff
    • , Chakrapani Kalyanaraman
    • , Rosmarie Friemann
    • , Matthew P. Jacobson
    • , Ernest M. Wright
    •  & Michael Grabe
  • Article | | open

    Integral membrane proteins are assembled into the ER membrane via the ribosome-translocon channel. Here authors use in vitro translation assays and MD simulations to show that folding in the ribosome is favorable for TM helices, but unfavorable for soluble helices.

    • Manuel Bañó-Polo
    • , Carlos Baeza-Delgado
    • , Silvia Tamborero
    • , Anthony Hazel
    • , Brayan Grau
    • , IngMarie Nilsson
    • , Paul Whitley
    • , James C. Gumbart
    • , Gunnar von Heijne
    •  & Ismael Mingarro
  • Article | | open

    Clostridium difficile causes diarrhea and colitis by producing up to three different protein toxins. Here, Tam et al. show that an anthelmintic drug, niclosamide, inhibits the pathogenesis of all three toxins by targeting a host process required for toxin entry into host cells, without disrupting the gut microbiota.

    • John Tam
    • , Therwa Hamza
    • , Bing Ma
    • , Kevin Chen
    • , Greg L. Beilhartz
    • , Jacques Ravel
    • , Hanping Feng
    •  & Roman A. Melnyk
  • Article | | open

    Myotonic dystrophy type 1 (DM1) is associated with aberrant transcript splicing. Here, the authors develop a transgenic mouse model expressing a bi-chromatic reporter system that allows non-invasive monitoring of splicing of a transcript altered in DM1 in vivo, and show that it allows for evaluation of the therapeutic response to treatment with antisense oligonucleotides.

    • Ningyan Hu
    • , Layal Antoury
    • , Timothy M. Baran
    • , Soumya Mitra
    • , C. Frank Bennett
    • , Frank Rigo
    • , Thomas H. Foster
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  • Article | | open

    Histone lysine demethylases (KDMs) can mediate transcriptional reprogramming in disease states. Here the authors show that KDM3A promotes left ventricular hypertrophy and cardiac fibrosis by activating the transcription of Timp1, and that pharmacological inhibition of KDM3A attenuates cardiac remodeling induced by pressure overload.

    • Qing-Jun Zhang
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    • , Kristen M. Kokkonen-Simon
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    • , Joseph A. Hill
    • , Eric N. Olson
    • , David A. Kass
    • , Elisabeth D. Martinez
    •  & Zhi-Ping Liu
  • Article | | open

    Cyclins A2 and E1 are known to regulate the cell cycle by promoting S phase entry and progression. Here, they identify an aggressive hepatocellular carcinoma subgroup exhibiting cyclin activation through various mechanisms and find this subgroup to display replication stress-induced structural rearrangements frequently activating TERT promoter.

    • Quentin Bayard
    • , Léa Meunier
    • , Camille Peneau
    • , Victor Renault
    • , Jayendra Shinde
    • , Jean-Charles Nault
    • , Iadh Mami
    • , Gabrielle Couchy
    • , Giuliana Amaddeo
    • , Emmanuel Tubacher
    • , Delphine Bacq
    • , Vincent Meyer
    • , Tiziana La Bella
    • , Audrey Debaillon-Vesque
    • , Paulette Bioulac-Sage
    • , Olivier Seror
    • , Jean-Frédéric Blanc
    • , Julien Calderaro
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Jaeok Park et al./doi:10.1038/ncomms14132

Therapeutics

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