A lattice of protein tetramers

A self-assembling 2D lattice protects replication of a bacterial virus

Some bacterial viruses enclose their replicating DNA in a protein-based ‘phage nucleus’. Nieweglowska et al. show that the structure is a lattice of tetramers linked by flexible loops and tails.


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Latest Research articles

Subjects within Physical sciences

  • Protected areas are important for climate change mitigation. Here, the authors use satellite data and statistical matching to show that terrestrial protected areas have higher C stocks than non-protected areas, roughly equivalent to one year of annual global fossil fuel emissions.

    • L. Duncanson
    • M. Liang
    • A. Zvoleff
    ArticleOpen Access
  • This study investigates the seasonal catchment memory of rivers in the Tibetan Plateau, with the help of a water storage change model. Understanding catchment memory can aid in hydrological forecasts and water resource management

    • Haiting Gu
    • Yue-Ping Xu
    • Yuxue Guo
    ArticleOpen Access
  • Using data from the Tara Pacific expedition to investigate symbiont fidelity and patterns of gene expression across a thermal gradient, this study shows that Pocillopora corals have a three-tiered strategy of thermal acclimatization that is underpinned by host–photosymbiont specificity, host transcriptomic plasticity, and differential photosymbiotic associations under extreme warming.

    • Eric J. Armstrong
    • Julie Lê-Hoang
    • Patrick Wincker
    ArticleOpen Access
  • Using data from the Tara Pacific expedition, this study reports the biogeography and the diversity of microbiomes collected from corals, fish and plankton in 99 reefs across the Pacific Ocean. The large richness of Pacific Ocean reef microorganisms, when extrapolated to all fish and corals of the Pacific, represents the current estimated total prokaryotic diversity for the entire Earth.

    • Pierre E. Galand
    • Hans-Joachim Ruscheweyh
    • Serge Planes
    ArticleOpen Access

Subjects within Earth and environmental sciences

Subjects within Biological sciences

  • Lung cancer screening could enhance early diagnosis and treatment. Here, the authors used proteomic analysis of pre-diagnosis samples across 6 cohorts to identify 36 proteins associated with imminent lung cancer diagnosis.

    • Demetrius Albanes
    • Karine Alcala
    • Wei Zheng
    ArticleOpen Access
  • Plasmodium knowlesi is a zoonotic malaria parasite that can infect humans, but whether human-mosquito-human transmission occurs is not known. Here, the authors use data from Malaysia and show, through mathematical modelling, that sustained non-zoonotic transmission is unlikely to be occurring in this setting.

    • Kimberly M. Fornace
    • Hillary M. Topazian
    • Chris Drakeley
    ArticleOpen Access
  • Coagulation factor VIII deficiency in hemophilia A disrupts clotting and prolongs bleeding. Here, the authors show that vagus nerve stimulation bypasses this defect and improves hemostasis in hemophilia A mice through a mechanism requiring acetylcholine-secreting ChAT+ T lymphocytes in spleen and α7nAChR on circulating platelets.

    • Carlos E. Bravo-Iñiguez
    • Jason R. Fritz
    • Jared M. Huston
    ArticleOpen Access
  • Graft-versus-leukemia reactions are required for the eradication of myeloid malignancies after allogeneic hematopoietic cell transplantation. However, treatment efficacy is variable, depending on the immunological response. Here the authors show that dysfunction of HLA heterogeneity is associated with post-transplant leukemia relapse.

    • Simona Pagliuca
    • Carmelo Gurnari
    • Jaroslaw P. Maciejewski
    ArticleOpen Access

Subjects within Health sciences

Subjects within Scientific community and society

  • The Tara Pacific program and expedition focused on coral reefs across the Pacific Ocean and used a coordinated sampling effort to address questions at multiple scales using a common suite of samples. Here, we highlight some of the Tara Pacific achievements, discussing the benefits of long-duration sea expeditions for investigating a wide array of research questions within a selected ecosystem.

    • Serge Planes
    • Denis Allemand
    CommentOpen Access
  • The samples returned from near-Earth asteroid (162173) Ryugu provide a pristine record of the 4.6 billion years since the birth of the Solar System. The Hayabusa2 initial analysis team has integrated a range of analytical techniques to investigate Ryugu’s organic chemistry. Here, we highlight their latest findings, the potential questions which may be answered, and provide an overview of new prospects in the decade to come.

    • Yasuhiro Oba
    • Yoshinori Takano
    • Hiroshi Naraoka
    CommentOpen Access
  • Identifying topological defects in disordered materials has a profound effect on predicting when and where the material will break. Matteo Baggioli comments a recent publication in Nature Communications, which confirms the existence of defects in glasses and their crucial role for plasticity.

    • Matteo Baggioli
    CommentOpen Access
  • Early detection of immunotherapy-induced tumor response is of major benefit for patients but can be complicated by therapy-induced pseudoprogression. A consensus guideline-iRECIST- was developed as a modification of Response Evaluation Criteria in Solid Tumours (RECIST version 1.1). Here we describe which next steps are required to test its validity and how novel approaches for response criteria might be developed and included.

    • Elena Garralda
    • Scott A. Laurie
    • Elisabeth G. E. de Vries
    CommentOpen Access
  • Issues with data reuse have been recognized in synthetic biology and the broader scientific community. Policies and standards fall short as machine reasoning is not emphasised and enforcement is lacking. We discuss the progress, remaining challenges, and possible solutions.

    • Jeanet Mante
    • Chris J. Myers
    CommentOpen Access

Biotechnology and methods

Papers highlighted here represent a snapshot of some of the recent exciting work published in the area of bioengineering, genome engineering, metabolic engineering, synthetic biology, system and computational biology, cellular biotechnology and imaging, and therapeutic biotechnology.
  • Chuanfu An, Ross Cloney, Cara Eldridge, Philip Lössl, Aline Lueckgen, Doaa Megahed, Anne Mirabella and Lorenzo Righetto


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