An energy-efficient physical reservoir is crucial for reservoir computing (RC). Here the authors demonstrate an all-electric skyrmion-enhanced strain-mediated physical RC system and achieve a benchmark chaotic time series prediction.

The authors report a simple strategy to enable ultrahigh-Q guided-mode resonances by introducing a patterned perturbation layer on top of a multilayer-waveguide system. Such high-Q resonances are experimentally demonstrated with measured Q-factors up to 2.4 × 10⁵.

Melanin-like materials are becoming important for surface biofunctionalization due to versatile adhesion, but are challenging to prepare in a site-specific manner. Here, the authors report a method using progressive assembly on a catalytic template, for site-specific fabrication and patterning of melanin-like pigments.

Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Here, the authors report a core-shell structured microneedle array patch with programmed functions which dynamically modulates the wound immune microenvironment according to the varied healing phases

Mechanically interlocked architectures inspired the fabrication of numerous molecular systems, but the topological design of such architectures has not been fully explored from the nano- to the macroscopic scale. Here, the authors propose a MOFaxane, comprised of long chain molecules penetrating a microcrystal of metal– organic framework.

Tree growth in boreal forests is generally predicted to increase under warming. Here, the authors demonstrate a method to analyze physiologically informed temperature series of tree-ring data, finding potentially overlooked growth-temperature responses and projecting increasing risks of warming to boreal larch forests.

Dunes and woody-debris preserved in the rock record have been used to quantify the magnitude and duration of flow events in ancient rivers, revealing a fluvial system dominated by flashy, storm-driven floods 300 million years ago.

Boreal forests are expanding at high latitudes yet declining at their southern boundaries. Here, the authors show that such trends are not symmetrical in North America, where poleward expansion of boreal forests did not offset southern declines often linked to wildfires and logging.

Nitrogen monoxide at low concentrations can promote the formation of highly oxygenated organic molecules, which are crucial precursors to secondary organic aerosol (SOA), rather than inhibit it as traditionally thought.

“Factors influencing soil microbiota functioning remain understudied. Here, the authors describe bacterial and fungal diversity across Europe and along a gradient of land-use perturbation, observing that the occurrence of pathogens, symbionts and saprotrophs varied among cropland, woodland and grassland.”

Here the authors show disturbing parental histone inheritance in cancer cells drives tumor progression by reprogramming the epigenetic profile and conferring fitness advantages to some of the newly emerged subclones.

Here, Li et al. show that functional redundancy, which has not previously been quantified at the proteome level, can arise when different microbes play similar roles in the gut microbiome, revealing that proteomes are nested among gut microbes, favoring high functional redundancy.

Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Here, the authors report a core-shell structured microneedle array patch with programmed functions which dynamically modulates the wound immune microenvironment according to the varied healing phases

Compact RNA structural motifs control many aspects of gene expression, but methods for their identification are lacking. Here the authors present a sequencing-based terbium probing approach to detect complex 3D structural elements, which can be used to pinpoint potential riboregulatory elements.

Quinol-dependent nitric oxide reductases, unique to bacteria, are considered members of respiratory heme copper oxidases. A 2.2 Å cryoEM structure of qNOR is reported shedding light on key aspects of enzyme mechanism including quinol binding and pathways for electron, substrate, and proton transport.

Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Here, the authors report a core-shell structured microneedle array patch with programmed functions which dynamically modulates the wound immune microenvironment according to the varied healing phases

The SART3 gene encodes an RNA-binding protein critical for spliceosome function. Here, the authors find that bi-allelic variants in SART3 underlie a congenital condition characterised by neuro-developmental defects and 46,XY gonadal dysgenesis.

The possibility of banking cryopreserved organs could make transplantation medicine much more accessible. Here, the authors show that vitrification and nanowarming—cooling organs to an ice-free state followed by rapid rewarming using nanoparticles and magnetic fields—enables organ cryopreservation, long-term banking, and recovery of full function in a rat kidney transplant model.

Current liquid-based optical clearing protocols can suffer from solvent evaporation and photobleaching. Here, the authors develop a solid high-refractive-index polymer to embed mouse and human tissues for clearing and antifade high-resolution 3D imaging.

The molecular mechanisms underlying androgen production in prostate cancer remain to be explored. Here, the authors reveal an epigenetic mark, K130Ac on H2A, following dual-phosphorylation on SREBP1 promoting de novo androgen synthesis to overcome the pharmacological inhibition of androgen synthesis.

Using two different mass spectrometric platforms, authors demonstrate how metabolomic data fusion and multivariate analysis can be used to accurately identify the geographic origin and production method of salmon.

Global COVID-19 vaccine distribution has been inequitable. In this mathematical modelling study, the authors estimate the proportion of deaths that could have been averted in twenty low- and lower-middle-income countries if vaccines had been more widely available early in the pandemic.

The potential for the mitigation of global non-CO₂ greenhouse gases is highly uncertain. Harmsen et al. estimate this uncertainty and show that it has large implications for the feasibility of reaching the Paris Climate Agreement targets.

The climate benefits of battery electric vehicles relative to internal combustion engine vehicles are favorable but usually delayed. The authors show the delay threshold in China and call for more attention to the temporal characteristics of climate benefits.

Humans and machines are increasingly participating in mixed collectives in which they can help or hinder each other. Here the authors show the way in which people treat machines differently than humans in a stylized society of beneficiaries, helpers, punishers, and trustors.