Digitized microscopy image of human kidney tissue

Deep learning analysis of tissue micrographs for improved diagnostics of kidney diseases

David Hölscher, Nassim Bouteldja et al. present a deep learning method for identification of specific features associated with non-tumor kidney disease in histological images.


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Latest Research articles

  • Probing single rare earth ions is highly desirable for several quantum applications, but it is difficult due to low emission rates. Here, the authors demonstrate the detection and control of single Erbium ions emission using electro-optically active photonic crystal cavities patterned from thin-film lithium niobate.

    • Likai Yang
    • Sihao Wang
    • Hong X. Tang
    Article Open Access
  • Manipulation of Janus particles is challenging and has limited precision. Here, the authors propose manipulation of Janus particles by optical forces in the evanescent field of an optical nanofiber, and demonstrate that they exhibit strong transverse localization on the nanofiber and much faster propulsion compared to all-dielectric particles of the same size.

    • Georgiy Tkachenko
    • Viet Giang Truong
    • Síle Nic Chormaic
    Article Open Access
  • Electro-optic modulators can be useful for imaging, sensing and information processing applications. Here the authors demonstrate an ultra-low drive voltage visible to near infrared range electro-optic modulator in the form of amplitude and phase modulation using thin-film lithium niobate.

    • Dylan Renaud
    • Daniel Rimoli Assumpcao
    • Marko Loncar
    Article Open Access

Subjects within Physical sciences

Subjects within Earth and environmental sciences

  • The timing of NAD + supply determines its efficacy to treat metabolic disease. Here, the authors show that increasing NAD + at the early active phase maximizes weight loss and glucose regulation in mice. NAD + can displace the phase of the liver clock which can cause circadian misalignment.

    • Quetzalcoatl Escalante-Covarrubias
    • Lucía Mendoza-Viveros
    • Lorena Aguilar-Arnal
    Article Open Access
  • The analysis of longitudinal bulk and single-cell multi-omics data is a highly complex task. Here, the authors introduce PALMO, a software platform with five modules to analyse longitudinal bulk and single-cell multi-omics data, which is extensively tested in external datasets that include multiple omics modalities.

    • Suhas V. Vasaikar
    • Adam K. Savage
    • Xiao-jun Li
    Article Open Access
  • The signal-to-noise ratio in bioimages is often low, which is problematic for segmentation. Here the authors report a deep learning method, deepflash2, to facilitate the segmentation of ambiguous bioimages through multi-expert annotations and integrated quality assurance.

    • Matthias Griebel
    • Dennis Segebarth
    • Christoph M. Flath
    Article Open Access
  • Ambrosia artemisiifolia is an invasive weed and primary cause of pollen-induced hayfever. Here, the authors report its chromosome-level phased genome assembly, examine genome-wide variation among modern and historic accessions, and identify large haploblocks underling rapid adaptation.

    • Paul Battlay
    • Jonathan Wilson
    • Kathryn A. Hodgins
    Article Open Access

Subjects within Biological sciences

Subjects within Health sciences

Subjects within Scientific community and society

  • The process of patenting inventions may be complex. Academic researchers whose primary goal is getting their work published in scientific journals often face daunting doubts when it comes to understanding the interplay between publishing and patenting their findings. We asked Prof Frank Tietze questions from the perspective of academic researchers who wish to understand how the patenting process works and—most importantly—the relation between patenting and publishing.

    Q&A Open Access
  • A recent study from Nature Communications reveals that Mycobacterium tuberculosis can hijack epigenetic machinery in host cells and induce host cell ferroptosis, which promotes pathogen pathogenicity and spread. These findings also suggest new therapeutic strategies to treat tuberculosis.

    • Boyi Gan
    Comment Open Access
  • Supramolecular chemistry based on cyclodextrin receptors as second-sphere ligands contribute to developing non-covalent materials with synergistic functionalities. Herein, we comment on a recent investigation of this concept, describing selective gold recovery through a hierarchical host-guest assembly specifically built from β-CD.

    • Anne Ponchel
    • Eric Monflier
    Comment Open Access
  • NASA’s Double Asteroid Redirection Test (DART) mission intentionally impacted the asteroid Dimorphos on September 26, 2022, and this kinetic impact changed Dimorphos’ orbit around its binary companion Didymos. This first planetary defense test explored technological readiness for this method of asteroid deflection.

    • Andrew S. Rivkin
    • Andrew F. Cheng
    Comment Open Access
  • A large proportion of recent Brazilian Amazon deforestation is occurring on untitled public forestlands through land grabbing. This emerging risk demands long-term conservation strategies. Here we propose prioritizing land tenure security, technological improvement, and law enforcement.

    • Paulo Moutinho
    • Claudia Azevedo-Ramos
    Comment Open Access

Nuclear and particle physics

Within this page, we will highlight our latest most interesting papers within the areas of nuclear and subnuclear physics, nuclear structure, nuclear materials and safety, quark-gluon plasmas, particle and astroparticle physics, and high-energy physics.


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