For the carbonylation reactions to synthesize aldehyde, ester, amide, and other carbonyl derivatives, a transition metal-free and CO- free reaction was challenging but highly demanded. Here, the authors report a transition metal-free and CO- free method for deoxygenetive/denitrogenetive conversion of phenols and anilines to aldehydes and ketones.

3D printing of functional gradients often requires specialized equipment and costly materials, constraining scalability. Here, using a conventional desktop FDM printer, authors present a 3D printing strategy using a filament that is itself 3D-printed to produce functional gradients.

Improving mass transfer through hierarchically porous synthetic materials is a great challenge. Here the authors address this by expanding the original Murray’s law, a biomimetic principle defining the branching of veins in living structures.

Machine learning has not been strategically applied to design main-group catalysts. Here, the authors built an in-silico library of triarylboranes, which was used to identify reactive catalysts for functionalizing amino acids and peptides with H₂.

Transparent roofs offer a solution for harnessing natural light in sustainable buildings. Here, authors demonstrate a polymer-based metamaterial with micro-pyramid surface structures that diffuses sunlight while offering passive cooling and self-cleaning properties.

When countries phase out coal, they compensate affected companies, communities and workers. Today more than $200 billion are allocated for such payoff, but much larger amount will be needed if China and India also phase out coal to tackle climate change.

Sustainable agricultural policies need to be practically assessed. Here, the authors assess how management practices affect ecosystem services in Swiss agricultural grasslands showing that organic farming has a lesser impact than the eco-scheme and the use as pasture or meadow.

The end of the green Sahara in the mid-Holocene was gradual, but punctuated by rapidly changing episodes of extreme drought and wetness, to which human societies were exposed and had to adapt to, as a lake record from southern Ethiopia suggests.

Here, the authors describe an early synziphosurine from the Lower Ordovician Fezouata Shale of Morocco, which exhibits traits that elucidate the long-contentious relationships between crown euchelicerates and their sister taxa, and also clarifies euchelicerate body plan evolution.

Sperm whales use sequences of clicks to communicate. Here, the authors show that these vocalizations are significantly more complex than previously believed-the “sperm whale phonetic alphabet" has both combinatorial structure and call modulation dependent on the conversational context.

c-di-AMP is essential for bacterial signaling. Here, the authors identify the GlcNAc-sensing regulator DasR as a c-di-AMP receptor and provide molecular insight into their signaling effect on the developmental and antibiotic biosynthesis control across Actinobacteria.

A mitochondrial actin wave fragments mitochondria. Here, the authors find that the wave produces force that is resisted by mitochondrial tethering, inducing fission, with subsequent fusion promoting mitochondrial content mixing and mitochondrial homeostasis.

Differentiation of stem and progenitor cells is a highly regulated process. Here, the authors uncover miR-144 and its target Hmgn2 as the backbone of the genetic regulatory circuit that controls the terminal differentiation of erythrocytes in vertebrates.

In Drosophila, long noncoding RNAs (lncRNAs) are expressed most highly in male germline cells. Here the authors report the subcellular distributions of approximately 600 Drosophila lncRNAs in male reproductive tissues, indicating potential involvement in spermatogenesis, fertility and evolution.

Ferritin, the cellular iron storage complex, binds NCOA4 and is trafficked to the lysosome for degradation and iron release. Here, authors present the cryo-EM structure of the NCOA4-Ferritin complex with biophysical and cellular characterization.

mRNA therapeutics delivered via lipid nanoparticles are being developed for the treatment of metabolic diseases caused by protein deficiency. Here, the authors use preclinical data to develop translational PK/PD models, which scaled allometrically to humans to predict starting doses for first-in-human clinical studies for in propionic acidemia, methylmalonic acidemia, and phenylketonuria.

Standard diagnostics are often not able to fully capture submicroscopic parasite dynamics after treatment with antimalarials. In this longitudinal analysis of molecular markers of malaria parasitemia in an Ugandan cohort, authors describe persistence of markers following antimalarial therapy with dynamic and complex multiclonal infections in the initial and post-treatment periods.

Many low- and middle-income countries, including The Gambia, had low COVID-19 vaccination coverage during the emergence of the Delta and Omicron variants. Here, the authors perform a prospective household cohort study in the Gambia to investigate the dynamics of SARS-Cov-2 infection in this setting.

Metabolic implications in AD are unclear. Here, authors found significant correlations between cognitive impairment and metabolic features in a Chinese aging cohort (n = 1397). The study highlights ammonia disturbance as a potential therapeutic target for AD.

FGFR inhibitors (FGFRi) benefit patients with FGFR2-fusion positive intrahepatic cholangiocarcinoma (ICC) but depth and duration of response is often limited. Here, the authors demonstrate that oncogenic FGFR2 signaling promotes a glycolytic phenotype, which is blocked by FGFRi, resulting in a targetable dependence on mitochondrial metabolism.

Sustainable agricultural policies need to be practically assessed. Here, the authors assess how management practices affect ecosystem services in Swiss agricultural grasslands showing that organic farming has a lesser impact than the eco-scheme and the use as pasture or meadow.

Decarbonizing the European ammonia industry: Less stringent emissions caps for electrolytic hydrogen production can significantly reduce costs and land use while still achieving more than 90% reduction in emissions relative to fossil-based hydrogen.

A hindcast experiment of the 2021 summer flood in West Germany unveils a 17-hour lead time for preparedness and advisable action, holding promise for impact-based forecasting of inundated roads, railways and building footprint in real-time.

Here, the authors show that elevated loneliness in adolescence and increasing loneliness over three decades is associated with heightened conspiracy beliefs in midlife.

A regulated stress response is essential for healthy child growth and development. Here, the authors show that a nutrition, water, sanitation, and hygiene intervention enhanced adaptive responses of the physiological stress system in early childhood.