Most machine-learning force fields dismiss long-range interactions. Here the authors demonstrate the BIGDML approach for building materials’ potential energy surfaces that enables a broad range of materials simulations within accuracies better than 1 meV/atom using just 10–200 structures for training.

Charging of interfaces between water and hydrophobic media is a mysterious feature whose nature and origin remain under debate. Here, the authors use opto-thermophoretic tweezers to investigate the interfacial behavior at water/oil interfaces in terms of thermal perturbation of dipole arrangement.

The discovery and control of the synthesis of metal–organic frameworks remains challenging due to the lack of understanding of their nucleation and growth. Here, the authors report a detailed molecular-level mechanism of the formation of MIL-53(Al).

Thermoelectric materials enable us to convert heat into electricity, but their application has been limited to high-temperature heat sources. Here, the authors show the direct conversion of low-grade waste heat into chemical energy via combining thermoelectric materials with biocatalysts below 100 °C.

The authors report passive mode-locking and frequency-comb generation induced by optical feedback in the resonant-tunneling-diode terahertz oscillator, a semiconductor-based oscillator covering the frequency range of 0.1 to 2 THz.

The 2021 eruption in the Reykjanes Peninsula of Iceland was the first in 800 years and was supplied by melts from diverse mantle source domains with near-identical oxygen isotope ratios, providing a unique insight into the Icelandic mantle plume.

This study presents seismic images across the central Tianshan. The results show that Tianshan’s crust was extensively deformed according to its inherited properties, but was limitedly underthrusted by surrounding blocks

Significant regional disparities exist in the time left to prepare for unprecedented drought and how much we can buy time depending on climate scenarios. Specific regions pass this timing by the middle of 21st century even with stringent mitigation.

While the evaporative water loss from global lakes is invisible, the volume is substantial. In recent decades, lake evaporation volume has been significantly increasing due to enhanced evaporation rate, melting lake ice, and expansion of water extent.

Understanding CD8 + T cell response to immune checkpoint blockade at the molecular level is important for the design of more efficient cancer immune therapies. Authors show here that the histone lysine methyltransferase Suv39h1 controls the transcriptional programs that determine the functionality of CD8 + T cells and Suv39h1 inhibition may potentiate anti-PD-1 therapy of melanomas.

Activating mutations of BRAF alone are inadequate to drive melanoma formation. Here the authors show that activation of Hippo signalling by oncogenic BRAF represents an additional safeguard to limit BRAF-dependent human melanocyte growth and melanoma formation.

KCNQ1 channels are active in heart, brain and gut. Functional loss causes epilepsy and sudden arrhythmic death. Here, authors describe a key activator drug binding site, explaining isoform and drug selectivity, and point the way for new drug design.

The reasons why malaria manifests with a variety of well-recognized clinical phenotypes remain poorly understood. Here, using distinct rodent models, the authors reveal that the microbiota colonizing the lung promotes respiratory distress syndrome and mortality during malaria infections.

Overproduction of efflux pumps represents an important mechanism of Klebsiella pneumonia resistance to tigecycline. Here, the authors design TPGS- and S-thanatin functionalized nanorods loaded with tigecycline to increase drug accumulation inside bacteria and overcome bacterial resistance.

Susceptibility to pneumonia has a genetic component, but specific genes involved remain poorly understood. In this study, genetic signals associated with pneumonia susceptibility are identified, providing information about disease biology and potential targets for treatment.

Insulin sensitivity declines with age via unclear mechanisms. Here, the authors show that the activity of membrane type 1 matrix metalloproteinase (MT1-MMP) is increased with ageing, leading to cleavage of the insulin receptor, and show that metabolic effects can be rescued by MT1-MMP inhibition in mice.

The impact of prior infection on the immune response to COVID-19 vaccination has not been fully characterised. Here, the authors use data from ~100,000 adults in the UK and find that a single vaccine dose in those with prior infection produces a comparable or stronger response to two doses in those without infection.

Floods are most devastating for those who can least afford to be hit. Globally, 1.8 billion people face high flood risks; 89% of them live in developing countries; 170 million of them live in extreme poverty making them most vulnerable.

An ethically-based method for allocating climate change mitigation effort among subsidiaries, applicable worldwide, is proposed. Applied to the EU Green Deal, this results in a wider range of targets than the Commission’s proposal of 2021.

New study shows how region-specific policy under the Avoid–Shift–Improve framework may aid in realizing a deep decarbonization in the transport sector and assist in achieving China’s carbon neutrality goals.

Without targeted climate adaptation, impacts of climate change threaten achievement of all 169 SDG targets. Fuldauer et al. provide an actionable framework to assess these impacts and help systematically align national adaptation plans with the SDGs.

Bioinks used in current in-situ bioprinting have limitations when applied to complex operational environments. Here, the authors report on the creation of a microgel reinforced GelMA bioink which can be simply prepared and used in different biomedical settings. The application is demonstrated in a cranial defect model.